New analysis finds significant disparities in the treatment of familial hypercholesterolemia

The Family Heart Foundation, a leading research and advocacy organization, shared results from an analysis of its large U.S. Family Heart DatabaseTM showing significant disparities exist in the treatment of familial hypercholesterolemia (FH) among racial groups, and by income and education levels. A real-world data analysis of more than 300 million individuals showed appropriate lipid-lowering therapy is more often prescribed for people with FH who are White, male, and have higher income, or have advanced education, leaving many others undertreated. The findings are being presented at the American Heart Association Scientific Sessions on Nov. 7 in Chicago in a poster titled, "Using Healthcare Claims Data and Machine Learning to Identify Health Disparities for Individuals with Diagnosed and Undiagnosed Familial Hypercholesterolemia."

Individuals with FH are at very high risk of premature cardiovascular events and require early and intensive lipid-lowering therapy, however, most individuals fall far short of receiving adequate care. These findings highlight the significant unmet need for improving equity and providing all individuals with FH an opportunity for cardiovascular risk reduction."

Mary P. McGowan, M.D., Chief Medical Officer, Family Heart Foundation, and co-author of the study

The observational study included patients diagnosed with FH and those likely to have FH but not yet diagnosed (probable FH). Probable FH patients were identified by the Family Heart Foundation's validated FIND-FH® machine learning model. Filled prescriptions for statins, ezetimibe, and PCSK9i, as well as age, education, income, race/ethnicity, and gender were assessed. Among more than 77 million individuals analyzed in this dataset, 280,426 had an FH diagnosis (51% female, 79.5% White, 11.8% Black, and 8.7% Hispanic) and 899,027 had probable FH (48% female, 78.7% White, 12.9% Black, and 8.5% Hispanic).

Key findings within both diagnosed and probable FH groups:

  • Compared to Blacks, Whites were 6 to 30% more likely to receive ezetimibe, PCSK9i, or the combination of statin, ezetimibe, and PCSK9i.
  • Males were 46 to 48% more likely to receive high-intensity statins compared with females.
  • Individuals with a household income of $100,000 and above were 30 to 50% more likely to receive ezetimibe, PCSK9i, or the combination of statin, ezetimibe and PCSK9i compared with individuals with household income less than $49,000.
  • Diagnosed FH patients with a college degree were 51% more likely to receive the combination of statin, ezetimibe and PCSK9i compared to those with a high school education or less.

The data analysis was performed on the Family Heart Database, comprised of diagnostic, procedural, and prescription data from claims and/or laboratory information for more than 300 million individuals in the U.S.

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