Fruit fly study highlights potential risks of cumulative blue light exposure

NewsGuard 100/100 Score

In a study on fruit flies, daily low-intensity blue light exposure (BLE), similar to that experienced daily by billions of humans in the form of LED lighting and device screens, changed flies at the sub-cellular level, affecting processes related to aging and circadian rhythms.

Xiaoyun Wang and colleagues exposed fruit flies (Drosophila melanogaster) to different durations of daily low-intensity BLE and then analysed the consequences to the cellular makeup of the insects, as compared to flies raised in darkness.

The authors paid particular attention to blue light's effects on N6-Methyladenosine (m6A), a modification of RNA common across the tree of life that plays a role in a wide range of processes. The authors found that blue light induced transcriptomic, m6A epitranscriptomic and metabolomic reprogramming. Ten-day old flies could be differentiated from 25-day old flies by each age group's m6A epitranscriptomic profiles, showing the link between m6A and aging. RNA profiles between 25-day old male blue light exposed flies' heads were significantly different from 25-day-old male dark-raised flies' heads.

According to the authors, the types of genes up- and down-regulated suggest that blue light exposure can damage neuronal function. In comparisons of whole-body transcriptomes, however, age created bigger differences between groups than light exposure, suggesting that eye and brain tissues of Drosophila are the major tissues affected by blue light. Differences in mRNA m6A levels and other m6A-related markers between light and dark raised flies indicate that m6A methylation was involved in the impacts of BLE on Drosophila. According to the authors, attention should be paid to the potential hazards of cumulative blue light exposure in humans.

Source:
Journal reference:

Huang, J., et al. (2023) Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. PNAS Nexus. doi.org/10.1093/pnasnexus/pgad390.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Sugar abnormalities in the blood may promote biological aging and inflammation in HIV patients