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Penn Nursing professor's book about children and drug safety wins Arthur J. Viseltear Prize

Cynthia Connolly's, PhD, RN, FAAN, book, Children and Drug Safety: Balancing Risk and Protection in Twentieth Century America, just received the distinguished Arthur J. Viseltear Prize.

23 Aug 2018

Comprehensive analysis reveals weaknesses to target in common pediatric solid tumor

St. Jude Children's Research Hospital investigators have completed the most comprehensive analysis yet of a common pediatric solid tumor, identifying weaknesses to target and a promising precision medicine that is now in clinical trials.

23 Aug 2018

Study provides new clues to connection between aging and neurodegeneration

For decades researchers have worked to shed light on the causes of neurodegenerative disorders, a group of devastating conditions, including Alzheimer's and Parkinson's, that involve the progressive loss of neurons and nervous system function. In recent years, numerous factors, from genetic mutations to viral infections, have been found to contribute to the development of these diseases.

23 Aug 2018

'Plastic antibodies' effectively target and eliminate tumor cells

A joint research team from Russia and the U.K. has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs, or "plastic antibodies." NanoMIPs are synthetic polymers that can function as antibodies, selectively binding to target proteins on the surface of cancer cells.

23 Aug 2018

Researchers complete testing a new drug to treat rheumatoid arthritis

An international research group led by Charité - Universitätsmedizin Berlin has completed testing a new drug to treat rheumatoid arthritis.

23 Aug 2018

Study suggests new possibilities for treating metabolic syndrome

New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes. Activating the gene also triggers an increase in calories burned, reduces fat accumulation and weight gain, and lessens measures of fats and cholesterol in the blood.

23 Aug 2018

Study finds new way to target escalating rates of obesity

A novel drug is being touted as a major step forward in the battle against Australia’s escalating rates of obesity and associated metabolic diseases.

23 Aug 2018

Pediatric antibiotic prescriptions lead to nearly 70,000 ER visits in the U.S. each year

The use of antibiotics drives the development of antibiotic resistance, a major threat to public health worldwide. But these drugs also carry the risk of harm to individual patients, including children.

23 Aug 2018

Researchers describe reason for rapid development of gender dysphoria

For individuals with gender dysphoria, the conflict between experienced gender identity and sex observed at birth produces significant emotional distress.

23 Aug 2018

Researchers describe how RNA polymerase detects UV light damage in DNA

Damage to DNA is a constant threat to cellular life, and so it is constantly monitored and detected by a family of enzymes called RNA polymerases, resulting in subsequent repair to maintain genome integrity.

23 Aug 2018

PETA reports show that animal research failed to benefit human health

Animal research has failed to benefit human health, wasted limited public research funds, misled clinicians, and harmed countless animals unnecessarily, finds a new report by PETA scientists Emily Trunnell, Ph.D., and Frances Cheng, Ph.D.

23 Aug 2018

Immunotherapy combination shrinks melanoma that has spread to the brain

Combination immunotherapy shrank melanoma that has spread to the brain in more than half of the patients in a clinical trial reported in the New England Journal of Medicine led by an investigator at The University of Texas MD Anderson Cancer Center.

23 Aug 2018

Scientists discover how a protein in the brain maintains 'energy rheostasis'

Scientists at the University of Michigan and Vanderbilt University have identified the function of a protein that has been confounding metabolism researchers for more than two decades. And it may have implications both for treating obesity and for understanding weight gain during pregnancy and menopause.

23 Aug 2018

FDA approves first drug for treatment of rare disease affecting the cornea

The U.S. Food and Drug Administration today approved the first drug, Oxervate (cenegermin), for the treatment of neurotrophic keratitis, a rare disease affecting the cornea (the clear layer that covers the colored portion of the front of the eye).

23 Aug 2018

Grim updates on Ebola outbreak in Congo

According to the health ministry, there have been five new cases of Ebola and five deaths from haemmorhagic fever. Ebola cases now sum up at 96 (5 new cases) from the town of Mabalako-Mangina. A total of 69 are confirmed. 55 people have died.

22 Aug 2018

Common ADHD drug may cause adverse psychotic side effects

In the scientific article recently published in Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Erica Ramstad and others reviewed the existing evidence between various psychotic symptoms such as hallucinations, problems with concentration or anxiety with methylphenidate, a drug commonly prescribed as a treatment for attention deficit hyperactivity disorder and narcolepsy.

22 Aug 2018

Surgically-removed tumor specimens can help quickly evaluate cancer drug efficacy

Genetic differences can affect the susceptibility of cancer cells to different drugs. In a new Molecular Oncology study, investigators show that surgically-removed breast and prostate tumor specimens can be used to rapidly screen different drugs to see which ones most effectively target an individual's cancer cells.

22 Aug 2018

Discovery could lead to new targeted treatment for people with lung cancer

Scientists have identified a key molecular player in a subtype of lung cancer which could lead to a new way to tackle the disease, according to research published in Nature Communications.

22 Aug 2018

Wyss researchers create model of the BBB-brain interface using microfluidically linked Organ Chips

The human brain, with its 100 billion neurons that control every thought, word, and action, is the most complex and delicate organ in the body. Because it needs extra protection from toxins and other harmful substances, the blood vessels that supply the brain with oxygen and nutrients are highly selective about which molecules can cross from the blood into the brain and vice versa.

22 Aug 2018

Study identifies strong link between sleep disorder and abnormal lipid level

In the Respirology study, investigators identified strong associations between several measures of OSA severity and higher total cholesterol, higher LDL-cholesterol, elevated triglycerides, and lower HDL-cholesterol.

22 Aug 2018