Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Lower body temperature found to directly influence glucose metabolism in mice

Some mammals are capable of hibernating during periods of low food availability in an effort to conserve energy and survive.

10 Jul 2025

Study finds no metabolic danger from ultra-processed foods

Research shows ultra-processed foods contribute to poor diet quality without a significant association to metabolic syndrome among European children and adults.

9 Jul 2025

Are you at risk? Waist size, not weight, could affect fertility in women

Researchers found that higher relative fat mass (RFM), a measure of visceral body fat, is significantly associated with increased infertility risk in U.S. women aged 20–44. The study suggests RFM may be a more sensitive screening tool for infertility risk than traditional BMI, especially in women with normal weight but high visceral fat.

3 Jul 2025

Mediterranean diet wins on weight but misses on memory in diverse aging population

A 14-month randomized trial in older African American adults with obesity found that adopting a Mediterranean diet, with or without calorie-restricted weight loss, significantly improved diet quality and reduced body weight and visceral fat. However, no cognitive benefits were observed compared to usual diet.

2 Jul 2025

Coffee’s hidden compounds could help fight type 2 diabetes

A comprehensive review of nearly 150 studies reveals that coffee polyphenols may help regulate blood sugar and reduce inflammation linked to type 2 diabetes. However, most evidence comes from preclinical research, and robust clinical trials are needed to confirm benefits.

29 Jun 2025

Just 150 minutes of exercise a week could reverse prediabetes

Engaging in more than 150 minutes of physical activity per week quadrupled the odds of reversing prediabetes to normal glucose levels in Colombian adults. Higher BMI and HbA1c remained strong barriers to reversal, highlighting the power of lifestyle interventions.

29 Jun 2025

Working in people-contact roles increase risk of type 2 diabetes

The emotional demands and confrontation inherent in person-contact roles, involving direct face to face or voice to voice interaction with external parties, are linked to a heightened risk of type 2 diabetes, suggests research published online in Occupational & Environmental Medicine.

25 Jun 2025

Experimental drug promotes weight loss by heating fat instead of suppressing appetite

An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to produce heat through a process known as thermogenesis, thereby promoting weight loss.

24 Jun 2025

US children who eat more fruit have less abdominal fat

Research shows that increased fruit consumption is associated with reduced abdominal fat in children, highlighting its importance in obesity prevention.

23 Jun 2025

Assessment of insulin resistance using TyG index flags rapid cognitive decline in Alzheimer's patients

Insulin resistance detected by routine triglyceride-glucose (TyG) index can flag people with early Alzheimer's who are four times more likely to present rapid cognitive decline, according to new research presented at the European Academy of Neurology (EAN) Congress 2025.

22 Jun 2025

Men lose more weight than women on the keto diet, new study reveals why

Men lose more weight than women on a ketogenic diet, according to a comprehensive review in Frontiers in Nutrition. Sex differences in hormones, metabolism, and fat distribution influence the effectiveness of the ketogenic diet for obesity.

22 Jun 2025

How early-life factors raise lifelong diabetes risks in youth

The surge in diabetes among young people highlights critical gaps in care and the urgent need for comprehensive preventative actions to address this crisis.

19 Jun 2025

What 300 grams of ultra-processed food a day does to your diabetes risk

A dose-response meta-analysis of 12 cohort studies finds that higher intake of ultra-processed foods (UPFs) is linked to a significantly increased risk of type 2 diabetes (T2D). The association remains even after adjusting for BMI, diet quality, and energy intake, with a steeper risk increase above 300 g/day.

17 Jun 2025

Muscle ultrasound shows promise for early insulin resistance detection

A simple ultrasound of a patient's thigh or shoulder muscle may detect insulin resistance before it progresses to type 2 diabetes or even prediabetes.

17 Jun 2025

Could a diabetes drug be the key to stopping Alzheimer’s?

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, linking diabetes and neurodegeneration.

17 Jun 2025

Meal and sleep timing play key roles in diabetes prevention

High-resolution digital tracking reveals how daily habits, meal timing, sleep, and physical activity shape metabolic risk for type 2 diabetes. Meal timing, sleep patterns, and activity windows each play distinct roles in insulin resistance and glucose control.

12 Jun 2025

APOE gene variants influence metabolic patterns linked to aging and Alzheimer’s risk

A new research paper was published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled "APOE genotype and biological age impact inter-omic associations related to bioenergetics."

12 Jun 2025

New guideline puts lifestyle interventions at the forefront of type 2 diabetes and prediabetes care

The American College of Lifestyle Medicine (ACLM) has published the first clinical practice guideline to put lifestyle interventions at the forefront of type 2 diabetes and prediabetes care.

10 Jun 2025

What happens to your body and mind during a five-day water fast?

A five-day water-only fast led to significant weight, fat, and lean muscle loss in middle-aged women, along with improved mood and marked changes in metabolic and inflammatory markers. The study also found that psychological traits like emotional intelligence and impulsivity influenced the amount of fat and muscle lost during fasting.

9 Jun 2025

Small weight loss leads to big gains in heart health

Even without weight loss, healthy lifestyle changes enhance heart health. This study highlights the importance of habits for cardiometabolic improvement.

9 Jun 2025