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Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.

3 Jan 2024

New synthetic antibiotic found to be more effective than established drugs against 'superbugs'

A new synthetic antibiotic developed by University of Liverpool researchers is shown to be more effective than established drugs against 'superbugs' such as MRSA, a new study shows.

3 Jan 2024

Cytonemes: The "express subways" of the developing nervous system

St. Jude Children's Research Hospital scientists found that cytonemes (thin, long, hair-like projections on cells) are important during neural development.

3 Jan 2024

Researchers identify microbial enzyme responsible for making urine yellow

Researchers at the University of Maryland and National Institutes of Health have identified the microbial enzyme responsible for giving urine its yellow hue, according to a new study published in the journal Nature Microbiology on January 3, 2024.

3 Jan 2024

Scripps scientists develop powerful method to find drug targets in live cells

Identifying new ways to target proteins involved in human diseases is a priority for many researchers around the world.

2 Jan 2024

Understanding acylspermidines' secrets could lead to treatments for various diseases

In a significant advancement in the field of biochemistry, scientists at the Boyce Thompson Institute (BTI) and Cornell University have uncovered new insights into a family of metabolites, acylspermidines, that could change how we understand aging and fight diseases.

2 Jan 2024

Scientists take a major step towards realizing synthetic CO2 fixing pathways in living cells

Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2).

2 Jan 2024

Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.

2 Jan 2024

How immune cells shape our earliest breaths

Study profiles the development of immune cells in human lungs during embryonic and fetal stages, revealing their influence on epithelial cell fate and lung development.

1 Jan 2024

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

28 Dec 2023

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

28 Dec 2023

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition.

27 Dec 2023

Researchers receive two grants to study tuberculosis drug development

Weill Cornell Medicine researchers and the TB Drug Accelerator have received two grants totaling $6.8 million from the Bill & Melinda Gates Foundation to study tuberculosis (TB) drug development.

26 Dec 2023

Study reveals how tiny tweaks to actin shape our cells

Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin.

22 Dec 2023

New family of polymers can kill bacteria without inducing antibiotic resistance

Antibiotic-resistant bacteria have become a rapidly growing threat to public health. Each year, they account for more than 2.8 million infections, according to the U.S. Centers for Disease Control and Prevention.

22 Dec 2023

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

22 Dec 2023

Molecule News and Research

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

New synthetic antibiotic found to be more effective than established drugs against 'superbugs'

Cytonemes: The "express subways" of the developing nervous system

Researchers identify microbial enzyme responsible for making urine yellow

Scripps scientists develop powerful method to find drug targets in live cells

Understanding acylspermidines' secrets could lead to treatments for various diseases

Scientists take a major step towards realizing synthetic CO2 fixing pathways in living cells

Small molecule-switchable RNA platform enables control of therapeutic protein expression

How immune cells shape our earliest breaths

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

Researchers receive two grants to study tuberculosis drug development

Study reveals how tiny tweaks to actin shape our cells

New family of polymers can kill bacteria without inducing antibiotic resistance

St. Jude researchers crack the code of the β2-adrenergic receptor

Protein "on/off switch" controls breast cancer spread and immunotherapy response

Stem cell heart tissue model paves the way for better understanding of tachycardia

First new antibiotic class in decades discovered using explainable AI platform

Deep learning unlocks new antibiotic classes, revolutionizing the fight against resistance

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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