Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

AI breakthrough offers a new way to predict and visualize disease processes

To solve a problem, we have to see it clearly. Whether it's an infection by a novel virus or memory-stealing plaques forming in the brains of Alzheimer's patients, visualizing disease processes in the body is the first step toward alleviating human suffering. It's also often the most difficult and costly.

16 Sep 2025

Mathematical model recreates swallowing and reveals causes of dysphagia

For most people, swallowing is second nature, but how does it occur, and why do some people have difficulty with it? Researchers at Kyushu University in Japan have started to tackle these questions by developing a mathematical model that recreates the muscle movements of the esophagus that occur during swallowing.

16 Sep 2025

Inside the lab of the future: Automation, NMR, and the power of integration

Discover how Bruker is changing the future of labs and NMR through its R&D efforts.

From Bruker BioSpin Group 16 Sep 2025

Study identifies thalamic pathway that reinforces alcohol seeking in withdrawal

What compels someone to keep engaging in alcohol use, even if it damages their health, relationships and wellbeing? A new study from Scripps Research offers an important clue: a small midline brain region plays a key role in how animals learn to continue drinking to avoid the stress and misery of withdrawal.

13 Sep 2025

Rice University team develops tool to track protein aggregation hot spots

A novel strategy developed at Rice University allows scientists to zoom in on tiny segments of proteins inside living cells, revealing localized environmental changes that could indicate the earliest stages of diseases such as Alzheimer's, Parkinson's and cancer.

13 Sep 2025

Texas Tech research team earns $3 million renewal to advance stroke therapy

Stroke research aims to understand the brain's self-protective and repair mechanisms. Gaining detailed insight into these mechanisms is crucial as such knowledge could lead to newly developed medications and interventions which mimic or engage the brain's self-protective/repair mechanisms, leading to innovative stroke therapies.

13 Sep 2025

Novel vitamin K analogs show promise for reversing neurodegenerative diseases

Neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's disease are characterized by the progressive loss of neurons.

13 Sep 2025

BioDlink Commends Junshi Biosciences as its Bispecific ADC Candidate JS212 Receives IND Approval

BioDlink, a leading global CDMO, extends its congratulations to Junshi Biosciences, on receiving Investigational New Drug (IND) approval

From BioDlink 12 Sep 2025

AI toolset reveals links between lung fibrosis and aging

A new research paper was published in Volume 17, Issue 8 of Aging-US on August 8, 2025, titled "AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging."

11 Sep 2025

Common wearable devices could remotely monitor pregnancy-related health changes

A simple fitness tracker might hold the key to revolutionizing maternal healthcare. Scientists at Scripps Research have found preliminary evidence suggesting that common wearable devices such as the Apple Watch, Garmin and Fitbit could remotely monitor pregnancy-related health changes by tracking physiological patterns-like heart rate-that correlate with hormonal fluctuations.

11 Sep 2025

Mapping the evolutionary trajectory of meningiomas at single-cell resolution

Meningiomas are the most common primary brain tumors, accounting for nearly one-third of all central nervous system (CNS) tumors.

11 Sep 2025

Novel method accurately identifies therapeutic antibodies to treat infectious diseases

Scientists at Scripps Research have developed a novel method that uses artificial intelligence (AI) and advanced imaging techniques to more accurately and efficiently identify therapeutic antibodies to treat infectious diseases.

10 Sep 2025

New AI model can identify treatments that reverse disease states in cells

In a move that could reshape drug discovery, researchers at Harvard Medical School have designed an artificial intelligence model capable of identifying treatments that reverse disease states in cells.

10 Sep 2025

New technique used to conduct real-time measurement of boron in live tumor cells

A new technique has measured boron in individual cancer cells for the first time, enabling researchers to better understand how drugs act to kill tumors in some cancers.

10 Sep 2025

Frailty and microbial imbalance drive GI complications in bladder cancer surgery

Gastrointestinal (GI) complications, such as postoperative ileus (POI) and intra-abdominal infections (IAI), remain a major concern after radical cystectomy for bladder cancer.

8 Sep 2025

Axxam and B'SYS partner to expand access to validated ion channel cell lines for high-throughput electrophysiology

Axxam S.p.A., a premier provider of integrated early drug discovery services, and B'SYS GmbH, a specialist in ion channel biology, are pleased to announce a strategic collaboration focused on enabling access to validated ion channel cell lines for hit and lead identification through high-throughput electrophysiological screening.

From Axxam S.p.A 8 Sep 2025

Blood-based biomarkers reveal barriers to diversity in Alzheimer’s disease trials

Some of the populations with the highest risk for Alzheimer's disease remain greatly underrepresented in clinical trials-and a new study helps explain why.

5 Sep 2025

Scientists uncover human proteins hijacked by SARS-CoV-2 for replication

Despite vaccines and treatments, SARS-CoV-2-the virus that causes COVID-19-continues to pose a global health threat, driven by new variants and its ability to hijack human cells in ways that still aren't fully understood.

5 Sep 2025

Atelerix and Rodon Global partner to integrate cryo-free preservation technology into specialist logistics solutions

Atelerix, a biotech company revolutionizing cell preservation and biological transport with its pioneering hydrogel encapsulation technology, today announced an agreement with Rodon Global (“Rodon”), the established freight company focused on clinical trials and drug discovery headquartered in South Africa.

4 Sep 2025

Beckman Coulter Life Sciences and HSE•AG partner to revolutionize nucleic acid quantification and purification through liquid handling

Beckman Coulter Life Sciences, a Danaher company and global leader in laboratory automation and innovation, is redefining nucleic acid quantification through a strategic collaboration with Hombrechtikon Systems Engineering•AG (HSE•AG), a Swiss provider of customized automation and engineering solutions for the life sciences and diagnostics sectors.

From Beckman Coulter Life Sciences 4 Sep 2025