Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Scaling organ‑chip technology for human‑relevant drug discovery

Discover how AVA brings scale and reproducibility to organ‑chip technology, enabling human‑relevant insights that accelerate drug discovery workflows.

From Emulate, Inc. 5 Aug 2025

LptM protein revealed as essential to outer membrane stability in bacteria

Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria.

4 Aug 2025

Promega Plasmid Collection, available through Addgene, equips industry and academic researchers with powerful bioluminescent assays that provide deeper insights into endogenous cellular biology

Addgene, a purpose-driven organization helping scientists conduct experiments with greater ease, speed, and reproducibility, today announced a strategic partnership with Promega to expand Addgene’s vast plasmid repository with the launch of the Promega Plasmid Collection.

From Promega Corporation 31 Jul 2025

Centauri Therapeutics receives an additional $5.1 M from CARB-X to progress ABX-01 lead compound to first in human clinical trials

Centauri Therapeutics Limited ('Centauri'), an immunotherapy company with a unique and proprietary platform technology applicable across a wide range of therapeutic indications, announced today that CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) has provided an additional $5.1 M in funding for the development of their lead compound.

29 Jul 2025

Australian scientists uncover new way to halt aggressive cancer growth

Australian researchers have discovered a promising new strategy to suppress the growth of aggressive and hard-to-treat cancers by targeting a specialized molecular process known as 'minor splicing'.

28 Jul 2025

Blocking nutrient scavenging weakens pancreatic tumor defenses

Cancer cells and tumors do not exist in a vacuum. Far from the isolation and self-sufficiency of the fictional Wakanda, tumors develop in and alter the nearby milieu of immune cells, connective tissue, blood vessels and a sea of proteins and carbohydrates that provide structure and other supportive functions.

24 Jul 2025

AI-driven microscopy predicts and tracks protein aggregation in real time

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's.

24 Jul 2025

New collaborative effort harnesses AI to drive ALS drug discovery in Louisiana

Answer ALS is proud to announce the launch of a groundbreaking collaborative initiative aimed at accelerating AI-powered drug discovery for ALS and other neurodegenerative diseases.

23 Jul 2025

New insights reveal how FtsZ and ZapA cooperate during bacterial cell division

Bacterial cell division, a process wherein a single cell divides to form two identical daughter cells, represents one of the most essential biological processes.

22 Jul 2025

Study shows how ribose may have become the sugar of choice for RNA development

In living organisms today, complex molecules like RNA and DNA are constructed with the help of enzymes.

22 Jul 2025

PhoreMost demonstrates new approach to rationalize molecular glue drug discovery

PhoreMost Ltd., a next-generation targeted protein degradation (TPD) company progressing a pipeline of degrader therapeutics within oncology and inflammation, today announced the publication of a study demonstrating the capabilities of its high-throughput GlueSEEKER platform to accelerate the design and development of novel molecular glue degraders.

22 Jul 2025

Novel polysaccharide from Albizzia julibrissin shows promise against pancreatic cancer

Albizzia julibrissin is a widely distributed plant in China. Its dried stem bark has been used in traditional oriental medicine to treat insomnia, diuresis, sthenia, ascaricide, and confusion.

21 Jul 2025

AI reshapes ARDS care by predicting risk, guiding ventilation, and personalizing treatment

Artificial intelligence and machine learning are transforming acute respiratory distress syndrome (ARDS) management, enabling earlier detection, precision risk stratification, and tailored therapies. Emerging AI techniques promise to improve outcomes, but real-world clinical validation and integration remain critical challenges.

21 Jul 2025

AI turns old diabetes drug Halicin into a potent weapon against superbugs

Researchers found that Halicin, an AI-identified drug, effectively inhibited most multidrug-resistant bacteria except Pseudomonas aeruginosa. The study highlights Halicin’s broad-spectrum antibacterial potential and the transformative role of artificial intelligence in antibiotic discovery.

20 Jul 2025

New machine learning model revolutionizes protein simulations

An international team led by Einstein Professor Cecilia Clementi in the Department of Physics at Freie Universität Berlin introduces a breakthrough in protein simulation.

18 Jul 2025

Scientists create liver organoids with functional blood vessels

Liver organoids with proper blood vessel networks have been successfully produced, as reported by researchers from Institute of Science Tokyo and Cincinnati Children's Hospital Medical Center.

17 Jul 2025

Study reveals how age and gender influence dietary patterns in Japan

As the age-old proverb rightly states, "You are what you eat." Our diet largely influences our health and well-being.

17 Jul 2025

Targeting amino acid networks could lead to more precise medicines

Amino acids play a fundamental role in regulating how cells respond to drugs. These molecules, which form proteins, act like bricks that communicate with each other within a structure.

16 Jul 2025

Staph bacterium possesses a surprising level of metabolic redundancy, study reveals

In the ongoing battle against antibiotic-resistant bacteria, MSU researchers have made a discovery that could reshape how we target deadly pathogens like staph infections.

16 Jul 2025

Optogenetic platform enables precise discovery of anti-aging therapeutics

A landmark study published in Cell has unveiled a first-of-a-kind optogenetic screening platform, developed by scientists at Integrated Biosciences, a biotechnology company integrating optogenetics, chemistry and AI to discover small molecule therapeutics for age-related diseases.

16 Jul 2025