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Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Highly sensitive CRISPR-based method designed to detect low-frequency cancer mutations

Liquid biopsy is increasingly recognized as a promising tool for cancer detection and treatment monitoring, yet its effectiveness is often limited by the extremely low levels of tumor-derived DNA circulating in the blood.

9 Dec 2025

Routine blood test may flag hidden osteoporosis risk, study finds

A large hospital-based cross-sectional study examined whether routinely measured serum alkaline phosphatase can indicate osteoporosis risk in adults undergoing health checks. Higher ALP levels, even within the normal range, were associated with greater osteoporosis likelihood, particularly in younger, female, and metabolically healthy individuals.

9 Dec 2025

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Supportive marital relationships are associated with lower BMI, fewer food addiction symptoms, higher oxytocin, stronger frontal brain responses to food cues, and favorable gut tryptophan metabolites. These coordinated social, neural, hormonal, and gut pathways suggest a plausible biological link between emotional support and healthier eating regulation.

8 Dec 2025

Older chemical libraries yield new leads for next-generation COVID-19 antivirals

SARS‑CoV‑2, the virus that causes COVID-19, continues to mutate, with some newer strains becoming less responsive to current antiviral treatments like Paxlovid.

8 Dec 2025

Lubiprostone shows signs of slowing kidney function decline in chronic kidney disease

In adults with stage IIIb–IV chronic kidney disease, the constipation drug lubiprostone did not reduce gut-derived uremic toxins but preserved creatinine-based kidney function over 24 weeks. The benefit was linked to microbiome remodeling, increased polyamine production, and improved mitochondrial function rather than toxin lowering.

8 Dec 2025

New combination treatment offers significant benefits for people with recurring grade 3 astrocytoma

Huntsman Cancer Institute at the University of Utah (the U) participated in a clinical trial that found that a new combination treatment plan helped people with recurring grade 3 astrocytoma, an aggressive form of brain cancer, live longer.

8 Dec 2025

Evidence grows for pirtobrutinib as a safer and effective alternative for CLL and SLL

Pirtobrutinib, a non-covalent Bruton tyrosine kinase (BTK) inhibitor, met the primary endpoint for non-inferiority in terms of overall response rate in the first head-to-head comparison with ibrutinib, a covalent BTK inhibitor.

7 Dec 2025

New combination treatment helps people with recurring grade 3 astrocytoma, trial shows

5 Dec 2025

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a mechanism that protects nerve cells from premature cell death, known as ferroptosis.

4 Dec 2025

Bacterial enzyme linked to heart complications in pneumonia

Pneumonia is a disease that burdens the healthcare system with more that 1.2 million emergency room visits each year and more than 41,000 adult deaths in the United States.

4 Dec 2025

Study shows glial cells actively shape addictive responses to nicotine

Nicotine addiction remains one of the most persistent public health challenges worldwide, driven by changes in the brain that reinforce repeated use and make quitting extremely difficult.

4 Dec 2025

Sugar alcohol sorbitol may increase the risk of developing steatotic liver disease

Sweeteners such as aspartame, found in Equal packets, sucralose (Splenda), or sugar alcohols are often seen as healthier alternatives to food with refined sugar (glucose).

3 Dec 2025

Ultrasound can aid in treating vascular occlusion events from cosmetic filler injections

Ultrasound can aid in treating complications from cosmetic filler injections, according to research being presented this week at the annual meeting of the Radiological Society of North America (RSNA).

3 Dec 2025

New method reveals how human cells initiate DNA replication

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, and genetic disorders. Therefore, understanding how cells replicate their DNA is crucial for elucidating fundamental biological processes, diseases, and even evolution.

3 Dec 2025

Enzyme News and Research

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Highly sensitive CRISPR-based method designed to detect low-frequency cancer mutations

Routine blood test may flag hidden osteoporosis risk, study finds

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Older chemical libraries yield new leads for next-generation COVID-19 antivirals

Lubiprostone shows signs of slowing kidney function decline in chronic kidney disease

New combination treatment offers significant benefits for people with recurring grade 3 astrocytoma

Evidence grows for pirtobrutinib as a safer and effective alternative for CLL and SLL

New combination treatment helps people with recurring grade 3 astrocytoma, trial shows

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Bacterial enzyme linked to heart complications in pneumonia

Study shows glial cells actively shape addictive responses to nicotine

Sugar alcohol sorbitol may increase the risk of developing steatotic liver disease

Ultrasound can aid in treating vascular occlusion events from cosmetic filler injections

New method reveals how human cells initiate DNA replication

Rice researchers develop resettable serum markers for clearer brain activity signals

Breakthrough platform reveals the choreography of mammalian transcription

Uncovering the hidden metabolic effects of soybean oil

Researchers uncover key mechanism blocking nerve regeneration in diabetes

New 10-minute scan shows hidden cause of high blood pressure

Understanding the DNA Damage Response in Innate Immunity eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo