Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

C-Path supports innovative ALS, neurodegenerative disease research with new grant

Critical Path Institute's (C-Path) Translational Therapeutics Accelerator (TRxA) announced today a new research grant awarded to Daniela C. Zarnescu, Ph.D., Professor of Cellular and Molecular Physiology at Penn State University College of Medicine, in collaboration with Jon Njardarson, Ph.D., Professor at the University of Arizona.

8 Aug 2024

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Using zebrafish "Avatars", an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López – a former PhD student at the lab now working at the Universidad de las Américas in Quito, Ecuador – and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine's action on bladder cancer cells.

8 Aug 2024

Breakthrough molecule reverses Alzheimer's symptoms

In a new study, a molecule identified and synthesized by UCLA Health researchers was shown to restore cognitive functions in mice with symptoms of Alzheimer's disease by effectively jumpstarting the brain's memory circuitry.

8 Aug 2024

New compound ZTA-26 could be a game-changer in lipid metabolism regulation

Scientists at Nagoya University in Japan have made a significant breakthrough in treating lipid disorders.

6 Aug 2024

FDA approves AChEI ALPHA-1062 for Alzheimer’s disease treatment

On July 29, 2024, the U.S. FDA approved Alpha Cognition Inc.'s ALPHA-1062 (Zunveyl®), an Acetylcholinesterase (AChE) inhibitor, for treating mild-to-moderate Alzheimer’s disease.

From Sino Biological Inc. 5 Aug 2024

Study elucidates mechanisms behind G protein selectivity and efficacy in adenosine A2A receptor

In a groundbreaking study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor (A2AR).

1 Aug 2024

Novel electrical impedance technique enhances drug testing for cardiac safety

When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical.

1 Aug 2024

AI and three electrodes offer accurate heart condition diagnosis

To diagnose heart conditions including heart attacks and heart rhythm disturbances, clinicians typically rely on 12-lead electrocardiograms (ECGs) - complex arrangements of electrodes and wires placed around the chest and limbs to detect the heart's electrical activity.

1 Aug 2024

Study reveals serotonin's role in ependymoma tumor growth

Do neurons play a role in brain tumor growth and development? Scientists at St. Jude Children's Research Hospital and Baylor College of Medicine have evidence showing that, for childhood ependymomas, they do.

31 Jul 2024

2024 is shaping up to be “the year of iPSCs"

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From Axol Bioscience Ltd 31 Jul 2024

Quantum simulation drives breakthrough in drug development

Led by University of Melbourne theoretician and HPC expert Associate Professor Giuseppe Barca, a research team has achieved the first quantum simulation of biological systems at a scale necessary to accurately model drug performance.

31 Jul 2024

Duke-NUS expands research capabilities with appointment of Professor Hendrik Luesch from UF

Duke-NUS Medical School today announced the appointment of Professor Hendrik Luesch from the University of Florida (UF) as a joint faculty member.

30 Jul 2024

Duke-NUS scientist awarded major funding to develop therapeutics for chronic inflammation

Associate Professor Lena Ho from Duke-NUS Medical School has been awarded US$1.85 million (approx. S$2.51 million) to further her team's research in developing microproteins into therapeutic targets to treat chronic inflammation.

29 Jul 2024

Revolutionizing hepatocyte count for researchers

In this interview, NewsMedical speaks to DeNovix's Dan Schieffer about the new app developed for CellDrop, and how it aims to revolutionize hepatocyte count for the drug discovery industry, and more.

From DeNovix Inc. 29 Jul 2024

Insilico Medicine unveils Science42:DORA to streamline academic writing and research

Writing research papers is critical for disseminating scientific findings, but it does come with efficiency burdens, particularly for early-career researchers and non-native English speakers.

28 Jul 2024

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

The development of innovative medicines is an expensive, time-consuming and risky business. On average, it usually takes at least a decade and billions of dollars to bring a new drug from project initiation to approval.

25 Jul 2024

Study confirms esaxerenone as a safe and effective alternative for hypertension treatment

Researchers find that esaxerenone is a non-inferior alternative to trichlormethiazide for treating uncontrolled hypertension in Japanese patients. The study confirms similar safety profiles for both drugs.

25 Jul 2024

$Study shows wearable health sensors only prompt a fraction of at-home tests$

Study shows wearable health sensors only prompt a fraction of at-home tests

When seemingly healthy people receive an alert from a wearable sensor telling them they might have a respiratory virus - based on small changes in their unique heartrate, sleep and activity patterns - what do they do? According to a new study by Scripps Research scientists carried out at the height of the COVID-19 pandemic, only a quarter of people follow up such an alert with an at-home viral test.

24 Jul 2024

Metrion Biosciences appoints Dr Chris Mathes as Chief Commercial Officer

Metrion Biosciences Ltd (“Metrion”), the specialist preclinical contract research organization (CRO) and a leader in ion channel screening, today announced the appointment of Dr Chris Mathes, MBA, as Chief Commercial Officer (CCO). Chris will work alongside the Company’s expert leadership team to drive commercial strategy and lead global business development and marketing activities.

24 Jul 2024

More types of lung cells can be infected by SARS-CoV-2 than previously thought, scientists report

Scientists at Sanford Burnham Prebys, University of California San Diego and their international collaborators have reported that more types of lung cells can be infected by SARS-CoV-2 than previously thought, including those without known viral receptors.

23 Jul 2024

Drug Discovery News and Research

Further Reading

C-Path supports innovative ALS, neurodegenerative disease research with new grant

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Breakthrough molecule reverses Alzheimer's symptoms

New compound ZTA-26 could be a game-changer in lipid metabolism regulation

FDA approves AChEI ALPHA-1062 for Alzheimer’s disease treatment

Study elucidates mechanisms behind G protein selectivity and efficacy in adenosine A2A receptor

Novel electrical impedance technique enhances drug testing for cardiac safety

AI and three electrodes offer accurate heart condition diagnosis

Study reveals serotonin's role in ependymoma tumor growth

2024 is shaping up to be “the year of iPSCs"

Quantum simulation drives breakthrough in drug development

Duke-NUS expands research capabilities with appointment of Professor Hendrik Luesch from UF

Duke-NUS scientist awarded major funding to develop therapeutics for chronic inflammation

Revolutionizing hepatocyte count for researchers

Insilico Medicine unveils Science42:DORA to streamline academic writing and research

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

Study confirms esaxerenone as a safe and effective alternative for hypertension treatment

Study shows wearable health sensors only prompt a fraction of at-home tests

Metrion Biosciences appoints Dr Chris Mathes as Chief Commercial Officer

More types of lung cells can be infected by SARS-CoV-2 than previously thought, scientists report

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