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Advances in diagnosis and management of systemic light chain amyloidosis

Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

30 Oct 2025

Rapamycin shows promise in treating cold tumors with specific gene mutation

Immune checkpoint inhibitors (ICIs) emerged in the US about 15 years ago as an exciting class of cancer treatments that have achieved complete and durable remissions for thousands of people with end-stage metastatic cancers.

29 Oct 2025

Understanding age-related changes in T cells and vaccine response

As flu season approaches and public health officials roll out their annual push for vaccination, Allen Institute scientists are learning why vaccines can trigger a weaker response in older adults, around age 65, and what can be done to improve them.

29 Oct 2025

MAGIC: A powerful tool to understand the origin of cancer

The human body relies on precise genetic instructions to function, and cancer begins when these instructions get scrambled.

29 Oct 2025

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Researchers found that microplastics from everyday plastic tableware accumulate in human semen and, although not linked to semen quality in the full cohort, were associated with altered sperm parameters in specific subgroups. Experimental models confirmed that 50 nm polystyrene particles trigger autophagy and apoptosis via the FOXA1/MAP3K1/p38 pathway, impairing sperm structure and function.

15 Oct 2025

Immune system found to be more mobile and flexible than previously thought

Researchers at Karolinska Institutet in Sweden have discovered that some natural killer cells, NK cells, temporarily reside in our organs and then leave them via the lymphatic system.

14 Oct 2025

Empowering genomics research with cloud-based innovation

Discover how Discovery Life Sciences enhances genomics research with cloud-based platforms like DNAnexus.

From DNAnexus, Inc. 8 Oct 2025

Restoring delta cell function may prevent dangerous hypoglycemic events in diabetes

A new study by the University of California, Davis, shows how cells work together to avoid a sudden drop in blood sugar. Understanding these feedback loops could improve the lives of people with diabetes and help them avoid dangerous hypoglycemia.

3 Oct 2025

Super-resolution imaging unlocks the role of transporter nanoclusters in tumor metabolism

Serine serves as a metabolic nexus in tumors, coordinating one-carbon metabolism, nucleotide synthesis, and redox regulation. In recent years, targeting the serine metabolic pathway, particularly the rate-limiting enzyme PHGDH, has attracted considerable attention as a promising anticancer strategy.

29 Sep 2025

Researchers develop tool to predict how patients will respond to common multiple sclerosis drug

Brazilian researchers, in partnership with French institutions, have developed a tool that can predict how patients will respond to natalizumab, one of the most commonly used drugs for treating multiple sclerosis.

25 Sep 2025

New PET tracer enables rapid imaging of aggressive breast and bladder cancers

A promising new PET tracer can visualize a protein that is commonly overexpressed in triple-negative breast and urothelial bladder cancers within four hours, according to new research published in the September issue of The Journal of Nuclear Medicine.

22 Sep 2025

Neurons play a key role in reducing lung inflammation in pulmonary fibrosis

Researchers at the University of Calgary studying a lethal lung disease called pulmonary fibrosis have found neurons, which were known to help detect pain, are also critical for reducing harmful lung inflammation that leads to the disease.

16 Sep 2025

Study reveals how centenarians preserve youthful immune defenses

Researchers mapped immune cells from centenarians, their offspring, and younger controls across three cohorts using multi-omics single-cell profiling. They found that centenarians retain leaner helper pools but have enhanced cytotoxic and NK cell programs, along with reinforced NK–T communication networks.

15 Sep 2025

SwRI and UT San Antonio advance biosensor coating to streamline production of immunotherapies

Southwest Research Institute (SwRI) and The University of Texas at San Antonio (UT San Antonio) are advancing a smart biosensor coating to streamline the production of immunotherapies for cancer treatments.

15 Sep 2025

Beckman Coulter Life Sciences launches industry-first infrared dye antibody conjugates to expand human phenotyping experiments

Beckman Coulter Life Sciences, a Danaher company and a global leader in laboratory automation and innovation, announces the launch of its new IR820 and IR870 infrared dye antibody conjugates.

From Beckman Coulter Life Sciences - Flow Cytometry 15 Sep 2025

A universal solution emerges: Anti-linker antibodies simplify CAR-T detection and development

CAR-T cell therapy has demonstrated remarkable success in treating hematologic malignancies and is now expanding into solid tumors.

From Sino Biological Inc. 13 Sep 2025

Repurposed diabetes drugs boost CAR T therapy effectiveness in bladder cancer

Urothelial carcinoma (UC) is the second most common genitourinary cancer, leading to over 16,000 deaths a year in the United States. Despite recent advances, the 5-year survival rate for metastatic UC remains around five to ten percent.

12 Sep 2025

Belgian researchers uncover how dendritic cells respond to lipid nanoparticles in vaccines

Belgian scientists have uncovered new details about how the immune system responds to vaccines. Dendritic cells, which are key immune messengers that help kick-start the body's defenses, show specific responses to lipid nanoparticles.

27 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

Curcumin activates SIRT3 to protect bone structure in diabetic mice

In a new Scientific Reports study, curcumin protected bone-forming cells from high-glucose damage by activating the SIRT3/FoxO3a/NRF2 antioxidant pathway and restoring mitochondrial health. In diabetic mice, curcumin improved bone density and oxidative balance, highlighting its potential in osteoporosis prevention.

13 Aug 2025

Cytometry News and Research

Advances in diagnosis and management of systemic light chain amyloidosis

Rapamycin shows promise in treating cold tumors with specific gene mutation

Understanding age-related changes in T cells and vaccine response

MAGIC: A powerful tool to understand the origin of cancer

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Immune system found to be more mobile and flexible than previously thought

Empowering genomics research with cloud-based innovation

Restoring delta cell function may prevent dangerous hypoglycemic events in diabetes

Super-resolution imaging unlocks the role of transporter nanoclusters in tumor metabolism

Researchers develop tool to predict how patients will respond to common multiple sclerosis drug

New PET tracer enables rapid imaging of aggressive breast and bladder cancers

Neurons play a key role in reducing lung inflammation in pulmonary fibrosis

Study reveals how centenarians preserve youthful immune defenses

SwRI and UT San Antonio advance biosensor coating to streamline production of immunotherapies

Beckman Coulter Life Sciences launches industry-first infrared dye antibody conjugates to expand human phenotyping experiments

A universal solution emerges: Anti-linker antibodies simplify CAR-T detection and development

Repurposed diabetes drugs boost CAR T therapy effectiveness in bladder cancer

Belgian researchers uncover how dendritic cells respond to lipid nanoparticles in vaccines

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Curcumin activates SIRT3 to protect bone structure in diabetic mice

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