Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Newly discovered cell involved in rheumatoid arthritis could serve as treatment target

Researchers have made a discovery about a class of cells involved in rheumatoid arthritis that could instigate new treatments.

18 Nov 2019

Vaping wrecks immune cell function, increases infection risk

A new study published in the Journal of the American College of Cardiology shows that e-cigarettes have toxic effects on neutrophils function, making them a threat to human health by increasing the likelihood of infection with Gram-negative bacteria.

17 Nov 2019

Yale study uncovers why belly fat surrounding organs increases as people age

A study by researchers at Yale has uncovered why belly fat surrounding organs increases as people age, a finding that could offer new treatment possibilities for improving metabolic health, thereby reducing the likelihood for diseases like diabetes and atherosclerosis that stem from inflammation.

15 Nov 2019

New way to promote insulin production in pre-diabetes phase discovered

Nanyang Technological University, Singapore scientists have discovered that a type of immune cell known as 'pancreatic islet macrophages' is capable of promoting insulin production during the pre-diabetes phase.

15 Nov 2019

Research shows how bacteria associated with Crohn's disease tolerate antibiotics

Bacteria associated with Crohn's disease rely on multiple stress responses to survive, multiply, and tolerate antibiotics within white blood cells called macrophages, according to a study published November 14 in the open-access journal PLOS Pathogens by Olivier Espéli of the College de France and PSL Research University in Paris, France, and colleagues.

14 Nov 2019

Leukemia type B cell can transform into a macrophage through epigenetic changes

All the tissues of our body have the same DNA, but they perform very different functions and have very different aspects.

13 Nov 2019

UAB study suggests potential treatment target for IPF

Long-held dogma says lung fibrosis in diseases like idiopathic pulmonary fibrosis, or IPF, results from recurrent injury to alveolar epithelium that is followed by dysregulated repair.

12 Nov 2019

New textbook on mysterious and deadly cytokine storm syndrome

There's no telling where the call will come from, or when. But Randy Cron, M.D., Ph.D., professor of pediatrics and medicine at UAB, knows to expect them.

11 Nov 2019

Study shows ADA2 is a sensitive, specific biomarker for macrophage activation syndrome

According to new research findings presented at the 2019 ACR/ARP Annual Meeting, adenosine deaminase 2 (ADA2) in the peripheral blood is a sensitive, specific biomarker for macrophage activation syndrome, a potentially life-threatening complication of systemic juvenile idiopathic arthritis (systemic JIA)

10 Nov 2019

Liposomes cross blood brain barrier, could get healing drugs to stroke-affected brain

A new study from University of Manchester researchers, published in ACS Neuro, shows a high possibility of treating stroke patients using very small cell sacs called liposomes to bypass the blood brain barrier and carry lifesaving drugs to the brain to prevent damage following a stroke.

7 Nov 2019

Researchers identify new kidney cancer subtypes and clues to better diagnosis, treatment

In what is believed to be the most comprehensive molecular characterization to date of the most common - and often treatment-resistant - form of kidney cancer, researchers at Johns Hopkins' departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them.

From Johns Hopkins Medicine 31 Oct 2019

Factor responsible for formation of white blood cells has regulatory effect on adaptive immunity

Granulocyte colony-stimulating factor, which causes division and differentiation of bone marrow cells depending on the body's need for leukocytes, has a significant regulatory effect not only on innate, but also on adaptive immunity.

31 Oct 2019

Novel method for aggressive breast cancer detection

A new study in rats published in the journal Cell Reports shows that the pattern of RNA molecules produced within certain immune cells called macrophages, found within breast cancers (tumor-associated macrophages, TAMs), can tell whether the tumor is cancerous or not and indicate the type of outcome. The same pattern is present in humans as in mice. This makes it directly useful in predicting the nature of a breast tumor and its outcome.

30 Oct 2019

Chemotherapy-induced senescent cells eat neighboring cells

A new study has found that chemotherapy-induced senescent cancer cells feed on other neighboring cells to enhance their survival.

30 Oct 2019

New method can indicate prognosis of aggressive breast cancer

Aggressive forms of breast cancer often manipulate the immune response in their favor. This manipulation is revealed in humans by the same immunological "signature" as in mice. This is shown by a study carried out by scientists from the University of Bonn together with Dutch colleagues.

29 Oct 2019

Early detection, treatment may reduce risk of death from systemic JIA-associated lung disease

For thousands of children living with the debilitating disease systemic juvenile idiopathic arthritis, a class of medications known as "biologics" have produced dramatic, life-changing improvements.

29 Oct 2019

Researchers discover unexpected role of mTORC2 protein in colorectal cancer

New results from researchers at MedUni Vienna's Center for Pathobiochemistry and Genetics show that a protein called mTORC2, which is the target of newly developed cancer drugs, is not even active in colorectal cancer. mTORC2 activity was only found in certain immune cells, which actually need this protein to fight cancer cells.

24 Oct 2019

UChicago researchers reveal the secret of cancer-related Warburg effect

A new study, led by researchers at the University of Chicago, provides an answer to why cancer cells consume and use nutrients differently than their healthy counterparts and how that difference contributes to their survival and growth.

23 Oct 2019

Discovery reveals why newer PD-1 targeted therapies sometimes fail

Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute report a discovery that helps scientists understand why some tumors lack immune cell infiltration and are therefore unresponsive to newer PD-1 targeted therapies.

23 Oct 2019

Celiac disease may now be curable with biodegradable nanoparticles

A phase 2 trial just concluded shows that people with celiac disease may now be able to hope for a cure, through a treatment that makes the immune system tolerant towards gluten. This could eventually make it possible for such individuals to eat gluten-containing foods without fear.

22 Oct 2019