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GADD45B promotes apoptosis in intestinal injury through DNA demethylation

Intestinal ischemia/reperfusion (I/R) injury is a common pathophysiological phenomenon that is widely present in various primary intestinal diseases and systemic critical illnesses, potentially leading to multiple organ dysfunction and failure, with high morbidity and mortality.

5 May 2026

Study links microplastics in arterial plaque to fourfold increase in stroke risk

In a Perspective published today in the inaugural issue of Brain Health (https://doi.org/10.61373/bh026p.0006), an international team of investigators argues that the human microplastic burden has crossed the threshold from environmental concern to brain health emergency. The article appears alongside the launch of Brain Health, a new peer-reviewed journal from Genomic Press dedicated to the science of lifelong brain resilience.

5 May 2026

NIH awards $3.9 million grant to develop a non-opioid pain treatment

The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH), has awarded a $3.9 million grant to a multi-institutional team led by scientists at Sanford Burnham Prebys Medical Discovery Institute to develop a non-opioid pain therapeutic and advance it into a Phase 1 clinical trial.

4 May 2026

Study debunks steroid myths, framing creatine as an essential energy-providing molecule

Creatine, a compound often associated with gym-goers and athletes, has long been touted as a performance-enhancing supplement. But beyond the hype, what does science actually reveal about its effects on the body and mind?

4 May 2026

Identifying the ages when Alzheimer’s biomarkers sharply change

New research identifies critical ages for Alzheimer's biomarkers, enhancing screening strategies and understanding neurodegeneration across the aging spectrum.

1 May 2026

Food timing may shape how T cells respond to infection and therapy

Short-term nutritional state can reshape T cell metabolism, with post-meal lipid metabolism enhancing T cell metabolic capacity, cytokine production, and persistence after activation. The study identifies triglyceride-rich chylomicrons as key drivers of this effect, suggesting nutritional timing may matter for immune monitoring, vaccination research, and cell-therapy manufacturing.

30 Apr 2026

Five-target drug beats GLP-1/GIP therapy in obese diabetic mice

A Nature study reports a single-molecule GLP-1–GIP–lanifibranor quintuple agonist that targets incretin receptor-expressing cells while activating PPARα/γ/δ pathways. In obese and insulin-resistant mice, the compound reduced body weight, food intake, and hyperglycaemia more effectively than semaglutide or GLP-1R–GIPR co-agonism, while remaining a preclinical finding.

30 Apr 2026

New CAR T cell design boosts persistence and reduces toxicity

CAR T-cell therapy has transformed the treatment of hematologic malignancies, yet many patients do not achieve lasting benefit – often because the infused cells fail to expand or persist.

30 Apr 2026

Brief walking breaks help the body control sugar after carb-rich meals

Brief brisk walking breaks during prolonged sitting improved post-meal interstitial glucose responses in healthy adults after carbohydrate-rich meals, with the strongest effects seen in women. Gluteal fat showed a more stable glucose pattern than abdominal fat, suggesting it may help buffer carbohydrate-related glucose rises through depot-specific uptake and lipid-synthesis pathways.

29 Apr 2026

Oxidative stress in aging brain inhibits essential enzymes

Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena found that oxidative stress in the aging brain inhibits the activity of deubiquitylases.

29 Apr 2026

New bioelectronic interface enables long-term vagus nerve stimulation for inflammation

Electrical stimulation of vagus nerve via implantable stimulators can effectively suppress inflammatory responses, offering a novel strategy for treating autoimmune diseases.

29 Apr 2026

Scientists redesign CAR-T cells to fight more than cancer

This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and next-generation immune-cell platforms. It highlights promising engineering advances, including universal CAR-T cells, in vivo delivery, CAR-NK cells, and safety switches, while emphasizing unresolved challenges in durability, safety, scalability, and global access.

29 Apr 2026

Epigenetic changes reshape Dicer enzyme function in cancer and reproduction

Activation of a specific part of the Dicer enzyme can change its shape in a way that affects its critical role in proper cell division, with implications for both cancer biology and fertility, according to researchers at The University of Texas MD Anderson Cancer Center.

28 Apr 2026

Study identifies protein essential for repairing damage after inflammation

Whenever there is a wound or infection, the body produces an inflammatory response. This is the body's first line of defense, and macrophages — cells of the innate immune system — play a key role: first, they help eliminate pathogens and other infectious agents, and then they trigger the mechanisms that repair the damage caused during the inflammatory process.

28 Apr 2026

Glycocalyx modification boosts immune cell targeting against B lymphoma

A new study published in Engineering provides mechanistic insights into live-cell glycocalyx engineering and supports the rational design of next-generation adoptive cell therapies (ACTs) against B lymphoma, addressing limitations such as high costs and restricted antigen specificity in current treatments.

25 Apr 2026

Fucosylated IgG drives adipose tissue dysfunction during aging

A study published in Engineering has identified fucosylated immunoglobulin G (IgG) as a key mediator contributing to adipose tissue dysfunction during aging, offering insights into age-related metabolic disorders and potential therapeutic targets.

25 Apr 2026

Restoring gut microbiome may prevent liver cancer in mice

Restoring the gut microbiome to its youthful state may hold the key to slowing aging and preventing liver cancer, one of the fastest-growing cancers worldwide, according to a study to be presented at Digestive Disease Week (DDW) 2026.

23 Apr 2026

New fiber probe enables real-time monitoring of key biomarkers

A new fiber probe developed by researchers at The University of Texas at Austin delivers two major innovations in health monitoring to help both patients around the world and the clinicians who care for them.

22 Apr 2026

Targeting glutamine metabolism enhances CAR-macrophage cancer therapy

Tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) exhibit significant metabolic dysregulation, which impairs their antitumor function.

20 Apr 2026

Why clinical proteomics faces a mass spectrometry vs. high-throughput profiling dilemma

This Clinical Chemistry and Laboratory Medicine review examines a central challenge in precision medicine: whether medical laboratories should prioritize metrologically sound, proteoform-resolving protein quantification by mass spectrometry or adopt scalable, affinity-based proteome profiling platforms built for high-throughput discovery and machine learning. It concludes that while emerging proteomics technologies expand diagnostic possibilities, careful validation, standardization, and quality assurance will be essential, with a hybrid path likely offering the most practical way forward.

19 Apr 2026