Next generation sequencing NGS News and Research

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Epigenetic clocks accurately predict age from human skeletal muscle

A new research paper was published in Volume 17, Issue 11 of Aging-US on November 26, 2025, titled "Epigenetic aging signatures and age prediction in human skeletal muscle."

30 Dec 2025

Aptamer Group and Alphazyme execute licensing agreement for synthetic aptamer-based enzyme modulation in hot-start PCR

Aptamer Group plc, a developer of synthetic oligonucleotide-based binding reagents for life sciences applications, and Alphazyme LLC (Alphazyme), a Maravai LifeSciences company specializing in enzymes for molecular biology, have executed a licensing agreement for a proprietary Optimer® binder developed for hot-start polymerase chain reaction (PCR) applications.

From Aptamer Group 24 Dec 2025

SARS-CoV-2 evolves after jumping from humans to zoo animals

Research on SARS-CoV-2 in zoo tigers, lions, and hyenas shows rapid viral evolution and adaptation, offering insights into cross-species transmission dynamics.

16 Dec 2025

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

In a new trial, patients with B-acute lymphoblastic leukemia (B-ALL) who had no evidence of remaining cancer cells after prior treatment, experienced comparable outcomes whether they received chemotherapy-based conditioning or total body irradiation (TBI), the standard conditioning regimen used before hematopoietic cell transplantation.

7 Dec 2025

Expert guidelines for fungal endophthalmitis in the Asia-Pacific region

Fungal eye infections affect millions globally, with an especially high incidence in South and Southeast Asia.

1 Dec 2025

Monitoring ctDNA can personalize the use of consolidation immunotherapy in patients with LS-SCLC

A new study presented at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC) demonstrates that monitoring circulating tumor DNA (ctDNA) can refine and personalize the use of consolidation immunotherapy in patients with limited-stage small cell lung cancer (LS-SCLC).

9 Sep 2025

Next-gen sequencing reveals the regulatory potential of the non-coding genome

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark achievements of the Human Genome Project (HGP), scientists have increasingly focused on deciphering the non-coding regions of the human genome, which comprise approximately 98% of the genetic material.

23 Aug 2025

n6™ announces strategic partnership with SeqCenter to deliver unmatched data quality in metagenomics

n6 is proud to announce a strategic partnership with SeqCenter, who is launching a groundbreaking full-length 16S sequencing service at FEMS Micro.

From n6 23 Aug 2025

n6 expands European presence to empower scientists and simplify NGS workflows

n6, the award-winning innovator in next-generation sequencing (NGS) workflow solutions, is proud to announce a major expansion of its European enablement efforts.

From n6 23 Aug 2025

Beneficial gut bacteria found to suppress harmful microbes

Intestinal bacteria are important for human health as they help digest food and regulate immune function. Thus, in recent years, it has become clear that gut microbiota dysbiosis, an imbalance in types and composition of intestinal bacteria, is associated with digestive disorders and other diseases.

1 Aug 2025

Gene-edited mosquitoes slash malaria spread 93% using self-propagating shield

Scientists engineered a naturally occurring genetic variant (Q224) in Anopheles stephensi mosquitoes, making them highly resistant to malaria parasites without affecting fitness. A novel gene-drive system rapidly spread this protective trait through lab mosquito populations, offering a potential breakthrough for malaria control.

24 Jul 2025

EAGLE model predicts key lung cancer mutations from routine biopsy

With EAGLE, lung cancer biopsy analysis is expedited, accurately predicting EGFR mutations and streamlining the diagnostic process for better patient outcomes.

14 Jul 2025

The Proteoform Puzzle: Unlocking the Next Frontier

In the interview, Lloyd M. Smith discusses proteoforms, an area of research worthy of the next Human Genome Project.

From Pittcon 10 Jul 2025

Intelligent, Scalable, Precise: How n6 Is Transforming NGS Library Prep

In this interview, the team at n6 discusses their groundbreaking iconPCR thermocycler and its impact on laboratory automation, NGS data quality, and real-time control in life sciences.

From n6 7 Jul 2025

Mutation profiles and clinicopathological correlations in lung squamous cell carcinoma

Lung Squamous cell carcinoma (LSCC) represents the second most common non-small cell lung cancer.

26 May 2025

Medicare claims for genetic cancer tests face growing rejection rates

Both the use of next-generation sequencing (NGS) testing for cancer and the rate of claim denials for such testing increased between 2016 and 2021, despite implementation of a recent Medicare national coverage determination that established coverage standards for NGS testing.

18 Apr 2025

Advancements in molecular diagnostics for hematopoietic and lymphocytic neoplasms

Hematopoietic and lymphocytic neoplasms (HLNs) are a diverse group of malignancies affecting blood and lymphatic systems, with outcomes varying from manageable conditions to fatal diseases.

27 Feb 2025

Researchers uncover how PICH protein protects DNA during cell division

Researchers at The University of Hong Kong (HKU) have made an exciting discovery about how human cells protect DNA during cell division, offering new insights into combating diseases such as cancer.

21 Jan 2025

Mayo Clinic researchers advocate for comprehensive TPMT genotyping across ancestries

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or African American descent. A novel study in The Journal of Molecular Diagnostics, published by Elsevier, details the researchers' goal to provide pharmacogenomic testing that can be used clinically to predict drug response that is beneficial to all patients, regardless of their ancestral background.

11 Dec 2024

Obe-cel demonstrates strong efficacy and safety in treating leukemia

Patients with relapsed or refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) who were treated with the novel anti-CD19 chimeric antigen receptor (CAR) T cell therapy, obecabtagene autoleucel (obe-cel), experienced high response rates and most did not need a subsequent stem cell transplant (SCT), according to results from the Phase Ib/II FELIX trial co-led by researchers at The University of Texas MD Anderson Cancer Center.

27 Nov 2024