Interleukin-17 (IL17): A pro-inflammatory cytokine that drives autoimmune diseases

T helper 17 (Th17) cells generate the pro-inflammatory cytokine interleukin-17 (IL17/IL17A). IL17 has been a target for a variety of therapeutic monoclonal antibodies and inhibitors to treat different inflammatory diseases and cancers due to its vital functions in immune control.

IL17 is part of a cytokine family that includes five other members: IL17B, IL17C, IL17D, IL17E/IL25 and IL17F. The sequences of IL17 and IL17F are the most similar. To signal through the receptor complex constituted of the subunits of IL17RA and IL17RC, IL17 and IL17F form homodimers and heterodimers (IL17A & IL17F). Both IL17 and IL17F have a role in attracting neutrophils to inflammatory areas.

The production of cytokines (IL-1β, TNFα, G-CSF, IL-6, etc.), chemokines (MCP-1/CCL2, CXCL1, CXCL2, CCL20, etc.), inflammatory effectors and antimicrobial proteins can be induced by IL17 and IL17F signaling.

At least two more ligands, IL17C and IL17E, utilize the IL17RA subunit. IL17RB, IL17RC, IL17RD and IL17RE are all members of the IL17 Receptor family. To aid in the research of the IL17 family of cytokines and receptor proteins, Sino Biological has created a panel of high-quality recombinant cytokines and receptor proteins, as well as antibodies.

Recombinant IL17 cytokines

Sino Biological has created bioactive recombinant IL17 cytokines from a variety of species, including humans, mice, cynomolgus, rats, ferrets and canines.

Recommended recombinant IL-17A cytokines

Source: Sino Biological Inc.

Catalog # Molecule Species Tag Expressed Host Activity
12047-H07B IL17A Human N-His Insect Cells Active
12047-H07Y IL17A Human N-His Yeast Cells Active
12047-HNAE IL17A Human Native E. coli Cells Active
12047-HNAS IL17A Human Native CHO Cells Active
51065-MNAE IL17A Mouse Native E. coli Cells Active
65006-T07B IL17A Rabbit N-His Insect Cells Active
65006-TNAE IL17A Rabbit Native E. coli Cells Active
70102-DNAE IL17A Canine Native E. coli Cells Active
90287-CNAE IL17A Marmoset Native E. coli Cells Active
90306-KNAB IL17A Rhesus Native Insect Cells Active
90880-CNAB IL17A Cynomolgus Native Insect Cells  
CT047-H08H IL17A & IL17F Human C-His HEK293 Cells Active
CT047-HNAE IL17A & IL17F Human Native E. coli Cells Active
CT063-K08H IL17A & IL17F Rhesus C-His HEK293 Cells  

 

Ability to induce IL-6 Secretion by NIH-3T3 mouse embryonic fibroblast cells in the presence of TNFα

Human IL17 Protein | 12047-HNAE.

Human IL17 Protein | 12047-HNAE. Image Credit: Sino Biological Inc

Human IL17A & IL17F Heterodimer | CT047-HNAE.

Human IL17A & IL17F Heterodimer | CT047-HNAE. Image Credit: Sino Biological Inc

Binding ability tested by ELISA

Rabbit IL17 Protein | 65006-T07B. Immobilized rabbit IL17A binds to rat IL17RA(Cat: 80190-R02H).

Rabbit IL17 Protein | 65006-T07B. Immobilized rabbit IL17A binds to rat IL17RA(Cat: 80190-R02H). Image Credit: Sino Biological Inc

Mouse IL17 Protein | 51065-MNAE. Immobilized mouse Il17A binds to mouse IL17RA(Cat: 50328-M08H).

Mouse IL17 Protein | 51065-MNAE. Immobilized mouse Il17A binds to mouse IL17RA(Cat: 50328-M08H). Image Credit: Sino Biological Inc

Recombinant IL17 receptors

  • IL17RA
  • IL17RB
  • IL17RC
  • IL17RD

Other related proteins

  • IL17B
  • IL17C
  • IL17E/IL25
  • IL17F

Antibodies for IL17 cytokines and receptors

Sino Biological has created a complete panel of antibodies that target IL17 cytokines and receptors for usage in ELISA, WB, Neutralization, FCM, IP and IHC. ELISA antibody pairs that are matched are also available.

  • Anti-IL17B
  • Anti-IL17C
  • Anti-IL17E/IL25
  • Anti-IL17F
  • Anti-IL17RA
  • Anti-IL17RB
  • Anti-IL17RC
  • Anti-IL17RD

IL17 / IL17A Neutralizing Antibody12047-M237.

IL17 / IL17A Neutralizing Antibody12047-M237. Image Credit: Sino Biological Inc

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