The c-Kit (CD117), receptor tyrosine kinase (RTK), and its ligand stem cell factor (SCF) are necessary for the development of embryos and the progression of human cancer. In gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), leukemia, mastocytosis, and glioblastoma, abnormal signaling of SCF/c-Kit is a crucial promoter of cancer stemness.
The c-Kit’s significance as a therapeutic target is noted by the more than 40 FDA-registered clinical trials that investigate immunotherapies targeting c-Kit in cancer treatment. As an international forerunner in recombinant technology, Sino Biological offers a varied range of recombinant proteins, ELISA kits, and antibodies to enable research and development of cancer therapies that target on c-Kit and other RTKs (VEGFR, EGFR, PDGFR, TrkB, c-Met, FGFR, etc.).
Image Credit: Sino Biological
Featured recombinant proteins related to SCF/c-Kit
Sino Biological has developed a panel of high-activity SCF and c-Kit proteins from different species to support the study on c-Kit and other RTKs.
- High Purity
- Activity Validated
- HPLC Verified
- Cited by Researchers
Human c-Kit protein
Purity: ≥ 90 % as determined by SEC-HPLC. Image Credit: Sino Biological
Immobilized human c-Kit protein can bind human SCF/c-kit ligand protein (Cat#: 10451-H08B). Image Credit: Sino Biological
Mouse c-Kit protein
Immobilized mouse SCF/c-kit ligand protein can bind mouse c-Kit protein. Image Credit: Sino Biological
Human SCF protein
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. Image Credit: Sino Biological
Featured antibodies and ELISA kits for detecting c-Kit
Sino Biological has developed an all-inclusive panel of antibodies targeting c-Kit. This can be employed in FCM, ELISA, IP, IHC-P, and WB. ELISA kits are also available.
Anti-c-Kit, Rabbit mab
Immunochemical staining of human c-Kit in human melanoma. Image Credit: Sino Biological
Human c-Kit ELISA kit
Human c-Kit concentration measured by c-Kit ELISA kit. Image Credit: Sino Biological
Anti-c-Kit, Mouse mab
Flow cytometric analysis of Human Kit (CD117) expression on HEL92 cells. Image Credit: Sino Biological
Anti-c-Kit, Rabbit mab
Whole cell lysates of MOLT4 (A), Jurkat (B) and K562 (C) probed with Anti-Kit rabbit monoclonal antibody. Image Credit: Sino Biological
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