Recombinant antigens are crucial reagents used in infectious disease research. They are commonly used for developing therapeutic antibodies and vaccines.

Sino Biological has individually designed the world’s largest recombinant viral antigen collection, called ProVir™. These antigens include a complete collection of influenza antigens, a unique coronavirus catalog and several other hard-to-find viral proteins, like RSV, Zika, Cytomegalovirus and Ebola.

The ProVir™ viral antigen bank contains more than 1000 antigens from 90 virus types and subtypes and 350 strains. It is extensively used across the world for infectious disease research, immunological assay, therapeutic antibody evaluation and vaccine development.

Recombinant SARS-CoV-2 variants

The P.1 variant, the B.1.351 variant, the B.1.1.7 variants, and the most latest B.1.617 variant—initially identified in India—specifically pose a major problem due to their high prevalence. Sino Biological has now designed a panel of recombinant RBD/Spike and nucleocapsid protein variants that can be used to assess the efficacy of the vaccination and antibodies.

Table 1. Source: Sino Biological Inc.

Lineage RBD S-ECD N
B.1.617.2 40592-V08H90 40589-V08B16 40588-V07E29
B.1.617 40592-V08H88 40589-V08B12 40588-V07E20
B.1.1.7 40592-V08H82 40589-V08B6 40588-V07E8
P.1 40592-V08H86 40589-V08B8 40588-V07E11
B.1.351 40592-V08H85 40589-V08B7 40588-V07E9

 

Recombinant antigens for influenza vaccine strains

The ProVir™ collection includes 630+ HA, ME, and NA antigens from more than 250 strains of influenza viruses, such as the pandemic strains and vaccine strains. In the recent past, Sino Biological has provided recombinant flu antigens from all vaccine strains recommended by WHO.

Table 2. Source: Sino Biological Inc.

Strains HA NA NP Year
A/Cambodia/e0826360/2020 (H3N2) 40789-V08H
40789-V08H1
40784-V08B 40778-V08B 2021-2022
A/Victoria/2570/2019 (H1N1) 40787-V08H
40787-V08H1
40785-V08B 40774-V08B 2021-2022
A/Wisconsin/588/2019 (H1N1) 40787-V08H
40787-V08H1
40785-V08B 40774-V08B 2021-2022
B/Phuket/3073/2013 40498-V08B 40502-V07B 40500-V08B 2021-2022
2020-2021
2019-2020
2018-2019
2017-2018
2016-2017
2015-2016
B/Washington/02/2019 40722-V08H 40790-V08B 40755-V08B 2021-2022
2020-2021

 

Recombinant antigens for more infectious viruses

The ProVir™ recombinant antigen series provides antigens from a wide range of viruses linked to several types of infectious diseases, such as Zika, Ebola, and also common viruses, like HPV, RSV and HIV. The ProVir™ also includes rare types of viruses, like the Vesicular stomatitis Indiana viruses and the Rift Valley fever.

Respiratory disease viruses

  • CMV
  • EV-D68
  • HAdV-B
  • HAdV-E
  • HPIV-3
  • HPIV-4
  • HMPV-A
  • HMPV-B
  • RSV
  • EBV
  • HCoV-229E
  • HCoV-HKU1
  • HCoV-NL63
  • HCoV-OC43
  • MERS-CoV
  • SARS-CoV

Hand, foot and mouth disease viruses

  • EV-71
  • CV

Blood-borne disease virus

  • HIV
  • HCV
  • HBV

Tropical and vector-borne diseases

  • DENV
  • CHIKV
  • WNV
  • ZIKV
  • RVFV

More disease viruses

  • EBOV
  • HTNV
  • HeV
  • VSIV
  • PCV2
  • SIV
  • CyCMV
  • DcCoV

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