The TREM (triggering receptor expressed on myeloid cells) family is a collection of cell surface receptors. This family has garnered much interest because of its ability to fine-tune the inflammatory response. TREM proteins, particularly TREM-1 and TREM-2, are presently being investigated as potential therapeutic targets for a variety of disorders, including neurological diseases, inflammatory diseases, and malignancies.

TREM-1, TREM-2, TREM-3, TREM-4/CLM-9/CD300LG, TREM-5/CLM-7/CD300LB, plasmacytoid dendritic cell-TREM (PDC-TREM), and TREM-like receptors TREML1/TLT-1 and TREML2/TLT-2 are all members of the TREM family.

TREM protein ligands have been elusive so far. TREM1 has only been linked to the high mobility group box 1 (HMGB1), extracellular actin, peptidoglycan recognition protein 1 (PGLYRP1), and cold-inducible RNA-binding protein (CIRP).

TREM2 ligand Amyloid, which is well-studied, is a crucial pathogenic protein in Alzheimer’s disease. B7-H3, a well-studied TLT-2 ligand, is essential for adaptive immune responses. The functional role of TREM ligands in diseases strengthens the case for TREM proteins as promising medicinal targets.

Sino Biological has created a set of recombinant TREM protein and antibody reagents to aid the research on the biology of this protein.

Recombinant TREM Proteins

Sino Biological has developed high-quality recombinant TREM proteins from rat, human and mouse sources.

Source: Sino Biological Inc.

Molecule Cat# Species Tag Expressed Host Purity
TREM-1 10511-H03H Human hFc&His HEK293 Cells >95%
TREM-1 10511-H08H Human His HEK293 Cells >90%
TREM-2 11084-H08H Human His HEK293 Cells >90%
TREM-2 50149-M02H Mouse hFc HEK293 Cells >90%
TREM-2 50149-M08H Mouse His HEK293 Cells >95%
TREM-4 13365-H02H Human hFc HEK293 Cells >95%
TREM-4 13365-H08H Human His HEK293 Cells >95%
TREM-4 13365-HCCH Human C-cleavage HEK293 Cells >95%
TREM-4 80413-R08H Rat His HEK293 Cells >95%
TREM-5 13650-H02H Human hFc HEK293 Cells >95%
TREML1 11934-H08H Human His HEK293 Cells >90%
TREML2 11655-H08H Human His HEK293 Cells >95%


Other Related Proteins

  • B7-H3
  • HMGB1
  • CIRP

Antibodies for TREM Proteins

Sino Biological has created a panel of antibodies that can be used in ELISA, IF, WB, FCM, IHC and IP to target TREM receptors and ligands from several species, including mice, humans, rabbits and rats.

Anti-TREML1, Rabbit Polyclonal | 204035-T02

TREM proteins and reagents for targeted immunotherapy

Immunofluorescence staining of TREML1 in jurkat cells. Image Credit: Sino Biological Inc.

Anti-TREML1, Rabbit Polyclonal | 204035-T08

TREM proteins and reagents for targeted immunotherapy

Immunochemical staining of human TREML1 in human spleen cell. Image Credit: Sino Biological Inc.

  • Anti-TREM-1
  • Anti-TREM-2
  • Anti-TREM-4
  • Anti-TREML1
  • Anti-TREML2
  • Anti-HMGB1
  • Anti-B7-H3

Other Equipment by this Supplier

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