Cell Biology

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Researchers discover previously unknown mechanism for how 'starvation response' is triggered

Body cells burn off fat reserves when nutrient supply from food ceases. A team led by Professor Volker Haucke and Dr. Wonyul Jang from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has now discovered a previously unknown mechanism for how this “starvation response” is triggered, and what can inhibit it.

15 Dec 2022

Researchers unravel the molecular mechanisms of steatosis-to-NASH progression

The global prevalence of nonalcoholic fatty liver disease (NAFLD) is estimated to be > 25% and will continue to rise.

15 Dec 2022

Study lays the groundwork for developing new technologies to detect neurodegenerative diseases

Researchers from the Neurobiology of miRNA team coordinated by Davide De Pietri Tonelli at the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology) has discovered the correlation between a class of small RNA molecules, piRNAs, and brain inflammation.

15 Dec 2022

Researchers discover how segmentation clock genes instruct the tempo of spine formation

One of the most dramatic phases of fetal development occurs as previously unstructured collections of rapidly dividing precursor cells begin forming the embryo's spine.

15 Dec 2022

Edible plant-based ink could reduce the cost of cultured meat production

Cultured meat (also known as cell-based or lab-grown meat) is a promising, more environmentally friendly alternative to meat produced from traditional livestock farming.

15 Dec 2022

Novel experimental system traces the development and longevity of plasma cells

Just as a fire department mobilizes in response to a reported fire, specialized immune cells in the body mobilize in response to the introduction of foreign substances known as antigens.

15 Dec 2022

Tiny messenger can be promising candidate for treatment of diseases associated with muscular atrophy

WNT messenger proteins are crucial for a variety of cellular functions. A specific WNT messenger can increase muscle mass and improve regeneration in skeletal muscle.

14 Dec 2022

Study reveals limited effects of longevity treatments on the aging process

Three approaches with a reputation for slowing aging processes have proven largely ineffective. For their study, researchers developed a new method to measure aging, which accounts for the complexity of aging in organisms.

14 Dec 2022

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.

14 Dec 2022

Specific bacteria in the bladder may indicate who is more prone to recurrent UTIs

Researchers at The University of Texas at Dallas have identified specific bacteria in the bladder that may indicate which postmenopausal women are more susceptible to recurrent urinary tract infections (UTIs), and they found that estrogen may play a role in reducing that susceptibility.

13 Dec 2022

'Cellular glue' opens the door to building tissues and organs

Researchers at UC San Francisco have engineered molecules that act like "cellular glue," allowing them to direct in precise fashion how cells bond with each other.

13 Dec 2022

Report makes recommendations clarifying the ethics and oversight of chimeric research

A new report on the ethics of crossing species boundaries by inserting human cells into nonhuman animals – research surrounded by debate – makes recommendations clarifying the ethical issues and calling for improved oversight of this work.

13 Dec 2022

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

The nanomaterial graphene oxide - which is used in everything from electronics to sensors for biomolecules - can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden.

12 Dec 2022

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

An international research team led by Dr Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into the mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

12 Dec 2022

Cell Biology

Researchers discover previously unknown mechanism for how 'starvation response' is triggered

Researchers unravel the molecular mechanisms of steatosis-to-NASH progression

Study lays the groundwork for developing new technologies to detect neurodegenerative diseases

Researchers discover how segmentation clock genes instruct the tempo of spine formation

Edible plant-based ink could reduce the cost of cultured meat production

Novel experimental system traces the development and longevity of plasma cells

Tiny messenger can be promising candidate for treatment of diseases associated with muscular atrophy

Study reveals limited effects of longevity treatments on the aging process

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Specific bacteria in the bladder may indicate who is more prone to recurrent UTIs

'Cellular glue' opens the door to building tissues and organs

Report makes recommendations clarifying the ethics and oversight of chimeric research

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

New computer model can help researchers to spot which cells acquire alterations during development

Researchers develop new porous material capable of regenerating bones and preventing infections

An epigenetic modification improves the defense against infections, research shows

Researchers discover a previously unknown mechanism that drives aging

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

The Proteoform Puzzle: Unlocking the Next Frontier

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

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