Cell Biology

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Understanding how the gut mycobiota respond to antibiotic treatment

Antibiotic treatment disrupts the balance of beneficial and harmful bacteria in a person's gut. That disruption can lead to the overgrowth of fungal species in the gut mycobiota, including the common intestinal yeast Candida albicans.

30 Nov 2022

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Studying mice has filled encyclopedias with breakthrough medical discoveries. But when it comes to brain cancers, the little rodents have long exhibited fundamental limitations.

30 Nov 2022

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the worst in otherwise peaceable cells? Or is it a back-and-forth, a dialogue between the two?

30 Nov 2022

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

30 Nov 2022

Inactivation of previously unknown gene found to be a likely culprit in the onset of pancreatic cancer

New research out of VCU Massey Cancer Center points to the inactivation of a previously unidentified gene as a likely culprit in the development of pancreatic cancer.

30 Nov 2022

Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

In our cells, the language of DNA is written, making each of us unique. A tandem repeat occurs in DNA when a pattern of one or more nucleotides – the basic structural unit of DNA coded in the base of chemicals cytosine (C), adenine (A), guanine (G) and thymine (T) – is repeated multiple times in tandem. An example might be: CAG CAG CAG, in which the pattern CAG is repeated three times.

30 Nov 2022

Bioorthogonal system for targeted release of nitrite ions into cancer cells

A team of researchers writing in the journal Angewandte Chemie has developed a bioorthogonal molecular system for the targeted introduction of nitrite ions into cells.

30 Nov 2022

Lysis and hypotonic sonication buffers for ChIP assays

Offering complete disruption of cytoplasmic and nuclear membranes, Porvair Sciences Chromatrap® buffer chemistries are optimised for sonication and enzymatic shearing.

From Porvair Sciences Limited 29 Nov 2022

Understanding the genetics of healthy brain cells to target vulnerabilities in glioblastomas

Understanding how cancer cells evolve from healthy brain cells and evade treatment could open up potential new drug therapies for glioblastomas, one of the most common and lethal brain cancers, new research has revealed.

29 Nov 2022

Study links MAIT cells to cognitive function

Could the underproduction of poorly understood immune cells contribute to Alzheimer's disease and other forms of cognitive decline? A Rutgers study in Nature Immunology suggests it may – and that increasing these cells could reverse the damage.

29 Nov 2022

Activation of microglial cells can slow down Alzheimer's progression

The brain's big-eating immune cells can slow down the progression of Alzheimer's disease. This is shown by a study that is now published in Nature Aging.

29 Nov 2022

UCSC engineers develop new method to automate the growth of cerebral organoids

A team of engineers at UC Santa Cruz has developed a new method for remote automation of the growth of cerebral organoids – miniature, three-dimensional models of brain tissue grown from stem cells.

28 Nov 2022

Imaging brain activity deep in the cortex of freely moving mouse

How does the brain produce behavior? Studying the brain during behavior is most informative when the animal is free to interact with its environment in any way it chooses.

28 Nov 2022

New microfluidic Organ Chip platform replicates the human vaginal tissue microenvironment

The human microbiome has been a hot topic over the last decade, with research pointing to disrupted bacterial communities as culprits for a host of maladies including irritable bowel syndrome, eczema, and autoimmune diseases.

28 Nov 2022

Rogue killer T cells associated with leukemia drive autoimmune diseases

Gene variants associated with leukemia can produce 'rogue' immune cells that drive autoimmune diseases, according to a new study from the Garvan Institute of Medical Research.

28 Nov 2022

Astrocytes in the brains of epileptic mice exhibit an acid response with intensified seizures

Researchers at Tohoku University have shown that astrocytes in the mouse brain exhibit an acid response with intensified epileptic seizures.

25 Nov 2022

New CRISPR-based tool can snip out faulty genes and replace them with new ones

Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.

24 Nov 2022

AI helps design synthetic DNA that controls cells' protein production

With the help of an AI, researchers at Chalmers University of Technology, Sweden, have succeeded in designing synthetic DNA that controls the cells' protein production.

24 Nov 2022

Duke researchers find human DNA sequence divergence after split from common ancestor of chimpanzees

A team of Duke researchers has identified a group of human DNA sequences driving changes in brain development, digestion and immunity that seem to have evolved rapidly after our family line split from that of the chimpanzees, but before we split with the Neanderthals.

24 Nov 2022

Krill oil rewires global gene expression programs and promotes healthy aging

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 21, entitled, "Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging."

24 Nov 2022

Cell Biology

Understanding how the gut mycobiota respond to antibiotic treatment

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Inactivation of previously unknown gene found to be a likely culprit in the onset of pancreatic cancer

Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

Bioorthogonal system for targeted release of nitrite ions into cancer cells

Lysis and hypotonic sonication buffers for ChIP assays

Understanding the genetics of healthy brain cells to target vulnerabilities in glioblastomas

Study links MAIT cells to cognitive function

Activation of microglial cells can slow down Alzheimer's progression

UCSC engineers develop new method to automate the growth of cerebral organoids

Imaging brain activity deep in the cortex of freely moving mouse

New microfluidic Organ Chip platform replicates the human vaginal tissue microenvironment

Rogue killer T cells associated with leukemia drive autoimmune diseases

Astrocytes in the brains of epileptic mice exhibit an acid response with intensified seizures

New CRISPR-based tool can snip out faulty genes and replace them with new ones

AI helps design synthetic DNA that controls cells' protein production

Duke researchers find human DNA sequence divergence after split from common ancestor of chimpanzees

Krill oil rewires global gene expression programs and promotes healthy aging

Unlocking live single-cell functional insights

Fluidics in Modern Healthcare & Medical Device Innovation

How microRNA is transforming science: From discovery to diagnostics

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