Cell Biology

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UCLA develops largest collection of patient-derived organoids for sarcoma research

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have developed the largest collection of sarcoma patient-derived organoids to date that can help improve the understanding of the disease and better identify therapies that are most likely to work for each individual patient.

20 Sep 2024

FUJIFILM Irvine Scientific develops Oceo Rover: The first automated single-use hydration system for media and buffers

FUJIFILM Irvine Scientific, Inc., a world leader in the development and manufacture of serum-free and chemically defined cell culture media for bioproduction and cell therapy manufacturing, today announced the development of Oceo Rover, a first-of-its-kind* single-use technology system, that enables manufacturers of biopharmaceuticals to improve bioprocessing workflows by automating and simplifying the hydration of media, feeds, and buffers.

From FUJIFILM Irvine Scientific 20 Sep 2024

Lipid metabolism plays a critical role in red blood cell recovery from acute anemia

Red blood cells are the most abundant cells in the body. It has long been known that when red blood cells break down or anemia occurs due to bleeding, the hormone erythropoietin (EPO) increases, leading to the proliferation of immature cells (erythroblasts) that eventually become red blood cells, thus restoring the red blood cell count.

20 Sep 2024

A novel in vitro model for studying wrinkle formation in biological tissues

A research team consisting of Professor Dong Sung Kim, Professor Anna Lee, and Dr. Jaeseung Youn from the Department of Mechanical Engineering at POSTECH has successfully recreated the structure of wrinkles in biological tissue in vitro, uncovering the mechanisms behind their formation. Their findings were published on August 19 in the international journal Nature Communications.

19 Sep 2024

New tool spots drug-resistant bacteria before treatment

Penicillin was hailed as "the silver bullet" when it was discovered, as it had the unprecedented quality of being able to kill disease-causing bacteria without harming the human body. Since then, a multitude of other antibiotics have been developed that specifically target a wide range of bacteria; but the more often they are used, the greater the risk that antibiotic-resistant strains will arise.

19 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

New kidney chip offers breakthrough for drug development and personalized medicine

Developing advanced drug screening tools is crucial for the advancement of personalized medicine and the creation of more effective treatments. One organ receiving particular attention in this area is the kidney.

19 Sep 2024

The importance of mitochondrial function in health and disease

The World Mitochondria Society (WMS) is preparing for its annual Targeting Mitochondria 2024 conference, which will focus on innovative strategies to "charge" cells by supplying them with extra mitochondria to enhance cellular function and combat diseases.

18 Sep 2024

Lipid molecule fuels cancer growth

Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes. Once alerted, the body's defenses can swoop in, destroying rogue cells before they can do much damage. Lying at the heart of this early warning system are lipids, fatty compounds previously seen by cancer biologists primarily as a fuel source for burgeoning tumors.

18 Sep 2024

Mechanically stimulated 3D multicellular systems

To study biomechanical forces in multicellular systems, effective mechanical stimulation is an essential tool. A 3D microstructure device is developed using Two-Photon Polymerization (2PP)-based 3D printing for mimicking the human multicellular environment.

From Nanoscribe GmbH & Co. KG 18 Sep 2024

LJI breakthrough offers hope for universal antiviral against filoviruses

At this moment, the world has few tools to combat deadly filoviruses, such as Ebola and Marburg viruses. The only approved vaccine and antibody treatments protect against just one filovirus species.

17 Sep 2024

Cell rejuvenation atlas unveils master regulators of rejuvenation strategies

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 17 on September 9, 2024, entitled, "The cell rejuvenation atlas: leveraging network biology to identify master regulators of rejuvenation strategies."

16 Sep 2024

Unveiling the mechanism behind DNA organization in early embryos

Researchers from the Kind Group have gained new insights into the mechanism behind the spatial organization of DNA within the cells of early embryos.

16 Sep 2024

Researchers uncover how brown fat cells increase metabolic activity

Special fat cells known as brown adipocytes help maintaining body temperature by converting calory-rich nutrients into heat.

16 Sep 2024

Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

New insight into the causes of autoimmune diseases

Autoimmune diseases are widespread and notoriously difficult to treat. In part, this is because why the immune system attacks its own tissues in patients with these conditions remains poorly understood.

14 Sep 2024

Biological condensates affect cellular behavior on a global scale

Most biological chemistry research has historically focused on the obvious cogs of machinery that keep life moving. Folding proteins, genetic activity and electrical signaling pathways are the easiest targets for finding irregularities that lead to disease.

13 Sep 2024

Nucleophagy identified as key DNA repair mechanism in cancer treatments

A team of international researchers at the University of Oxford (Oxford) and Nanyang Technological University, Singapore (NTU Singapore), has discovered a new process for repairing damaged DNA that is particularly relevant for patients undergoing colorectal cancer treatments.

12 Sep 2024

Concept neurons and location cells play key roles in memory formation

Certain nerve cells in the brain become active whenever they are confronted with different images or the name of a specific person or the identity of an object. They are highly selective and do not react to other people or objects.

12 Sep 2024

2-bromopalmitate reduces senescence phenotype in human cells by modulating palmitoylation

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 16 on August 23, 2024, entitled, "2-Bromopalmitate treatment attenuates senescence phenotype in human adult cells - possible role of palmitoylation."

11 Sep 2024