Cell Biology

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NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

In a new study, clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) have demonstrated the use of exosomes to successfully target squamous cell cancer tumours that are usually resistant to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Their research is the first where exosomes have been applied to target TKI-resistant cancers in Singapore. The findings were published in the journal Developmental Cell last month.

2 Sep 2024

Autophagy in HPCs modulates exosomal miRNAs to inhibit liver fibrosis

The study investigates the role of autophagy in hepatic progenitor cells (HPCs) and its potential to modulate exosomal microRNAs (miRNAs) to inhibit liver fibrosis in the context of schistosomiasis, a disease caused by parasitic flatworms that can lead to severe organ damage, particularly to the liver.

2 Sep 2024

Mosquito males’ visual and auditory cues reveal new insights for malaria control

A high-pitched buzzing sound in your ear is an unmistakable sign that a female mosquito is out on the hunt - for they, not males, drink blood. Hearing that tone might make you turn to try to swat the pest. But for a male mosquito, that tone means it's time to mate.

30 Aug 2024

EU-funded MASTER project develops first comprehensive database of food metagenomes

The first comprehensive database of food metagenomes has been developed by the EU-funded MASTER project.

30 Aug 2024

AI tool RENAISSANCE transforms creation of kinetic models in cellular metabolism

Understanding how cells process nutrients and produce energy - collectively known as metabolism - is essential in biology. However, analyzing the vast amounts of data on cellular processes to determine metabolic states is a complex task.

30 Aug 2024

Ingenza announces partnership with Cellugy to investigate the potential of biofabricated cellulose

Industrial biotech specialist Ingenza is delighted to announce that it is collaborating with Cellugy to accelerate the development of its innovative platform for producing biofabricated cellulose. This technology will provide a sustainable alternative to fossil-based petrochemicals in various industrial applications, starting with personal care. The new project will ultimately accelerate the understanding and optimization of bacterial cellulose production.

From Ingenza Ltd 30 Aug 2024

New bacterial defense mechanism revealed as potential tool for genome editing

Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method.

29 Aug 2024

Distinct waves of T cells generated by each dose of combination immunotherapy

A new tool for monitoring immune health patterns over time has revealed how a pair of checkpoint inhibitor therapies works together to recruit new cancer-fighting T cells with every infusion.

29 Aug 2024

Researchers uncover magnesium’s crucial role in cellular energy production

An international research team led by Umeå professor Magnus Wolf-Watz has discovered how the magnesium atom directs the chemistry that catalyzes the production of the energy molecule ATP in a cell. ATP is a vital driving force in the cell.

29 Aug 2024

NSF funds UCSB-led Biofoundry to revolutionize biotechnology with unexplored microbes

This week, the National Science Foundation announced the award of a six-year, $22M grant to UC Santa Barbara under its biofoundries program for the establishment of the BioFoundry for Extreme and Exceptional Fungi, Archaea and Bacteria (ExFAB), a collaboration led by UC Santa Barbara (UCSB), together with UC Riverside (UCR), and Cal Poly Pomona (CPP). ExFAB establishes the nation's first biofoundry that focuses on largely untapped and unexplored extreme microbes. UCSB's award is one of only five grants made under NSF's BioFoundry program during this funding cycle, which awarded a total of $75M to the five selected universities.

29 Aug 2024

New insights into AD pathogenesis and treatment

The main text of the study details the experiments conducted to understand the role of IL-24 in AD-like conditions. It describes the methods used, including single-cell RNA sequencing, and the animal models employed to mimic AD. The findings indicate that MRSA infection leads to increased IL-24 in keratinocytes, which in turn heightens type 2 immune responses and worsens AD symptoms.

29 Aug 2024

Novel microscopy technique reveals the mechanics of mitotic chromosome condensation

A team of scientists studying cell division developed a special light microscopy system and used it to analyze the molecular density of cellular environments. Their results provide a novel insight into mitotic chromosome condensation in living human cells.

29 Aug 2024

Study reveals how bacteria pass on traits without DNA changes

Bacterial cells can "remember" brief, temporary changes to their bodies and immediate surroundings, a new Northwestern University and University of Texas-Southwestern study has found.

28 Aug 2024

Researchers identify key cellular interactions driving Alzheimer's and aging

An analysis of more than 1.6 million brain cells from older adults has captured the cellular changes that occur in the early stages of Alzheimer's disease, potentially revealing new routes for preventing the most common cause of dementia in older individuals.

28 Aug 2024

Early embryos are prone to chromosomal copying errors, new research shows

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication.

28 Aug 2024

Study introduces a novel approach to mapping protein-receptor interactions

One in every three FDA-approved drugs targets a single superfamily of receptors dotting the surfaces of human cells.

28 Aug 2024

CDCA7 identified as key player in hemimethylation sensing

DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and a major way that DNA is epigenetically marked.

28 Aug 2024

Cell therapy commercialization: Streamline your path to cell therapy commercialization

Moving your cell therapy clinical trial beyond Phase I is an exciting time, marking a significant milestone. There are many therapeutic developers working to address critical patient needs in oncology, auto-immune, regenerative medicine, and other spaces.

From Charles Rivers Laboratories Cell and Gene Therapy 28 Aug 2024

Benefits of less intensive stem cell transplants for sickle cell disease

So-called low-intensity blood stem cell transplants, which use milder conditioning agents than standard stem cell transplants, do not appear to damage the lungs and may help improve lung function in some patients with sickle cell disease (SCD), according to a three-year study of adults who underwent the procedure at the National Institutes of Health (NIH).

28 Aug 2024

LncRNA ZNF593-AS offers hope for heart disease treatment

The research presented in the article delves into the regulatory role of the long non-coding RNA (lncRNA) ZNF593-AS in cardiac hypertrophy and myocardial remodeling, processes that are pivotal in the progression of heart failure and other cardiovascular diseases. The study uncovers how ZNF593-AS exerts its inhibitory effects by upregulating the expression of Mitofusin 2 (Mfn2), a protein known for its role in the regulation of mitochondrial dynamics and cellular metabolism.

28 Aug 2024

Cell Biology

NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

Autophagy in HPCs modulates exosomal miRNAs to inhibit liver fibrosis

Mosquito males’ visual and auditory cues reveal new insights for malaria control

EU-funded MASTER project develops first comprehensive database of food metagenomes

AI tool RENAISSANCE transforms creation of kinetic models in cellular metabolism

Ingenza announces partnership with Cellugy to investigate the potential of biofabricated cellulose

New bacterial defense mechanism revealed as potential tool for genome editing

Distinct waves of T cells generated by each dose of combination immunotherapy

Researchers uncover magnesium’s crucial role in cellular energy production

NSF funds UCSB-led Biofoundry to revolutionize biotechnology with unexplored microbes

New insights into AD pathogenesis and treatment

Novel microscopy technique reveals the mechanics of mitotic chromosome condensation

Study reveals how bacteria pass on traits without DNA changes

Researchers identify key cellular interactions driving Alzheimer's and aging

Early embryos are prone to chromosomal copying errors, new research shows

Study introduces a novel approach to mapping protein-receptor interactions

CDCA7 identified as key player in hemimethylation sensing

Cell therapy commercialization: Streamline your path to cell therapy commercialization

Benefits of less intensive stem cell transplants for sickle cell disease

LncRNA ZNF593-AS offers hope for heart disease treatment

Fluidics in Modern Healthcare & Medical Device Innovation

Scaling 3D biology: Automation, imaging, and the future of high-throughput research

How does norepinephrine influence anxiety-related behaviours?

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