Drug Discovery & Pharmaceuticals

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New candidate vaccine for COVID-19 found to be efficacious in preclinical models

More than a year after the start of the COVID-19 pandemic, several vaccines have been authorized thanks to unprecedented worldwide research efforts. These first-generation vaccines bring great hope and are a mainstay in fighting the virus.

1 Sep 2021

$1.3 million in NIH funding to enable drug delivery technology research

Two National Institute of Health grants totaling over $1.3 million will enable research into antibody-mediated drug delivery technology for the treatment of cancer and autoimmune disorders. L. Nathan Tumey, assistant professor of pharmaceutical sciences at Binghamton University, State University of New York, is the Principal Investigator on both grants - $1.2 million from the National Institute of General Medical Sciences and $150,000 from the National Institute of Allergy and Infectious Diseases.

31 Aug 2021

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with treatment-resistant cancers.

31 Aug 2021

Aston University secures KTP project to assist Catalent in developing orally disintegrating tablets

Aston University researchers based in the College of Health and Life Sciences have been awarded a Knowledge Transfer Partnership (KTP) project by Innovate UK, to bring its academic and scientific expertise to assist Catalent in the development of its Zydis® technology, the leading orally disintegrating tablet (ODT).

27 Aug 2021

Study suggests a balanced approach to developing safer opioid analgesics

Opioids are powerful painkillers but their use is hindered because patients become tolerant to them, requiring higher and higher doses, and overdoses can cause respiratory depression and death.

24 Aug 2021

Peptoids could one day cure or prevent herpes, COVID-19

In addition to antibodies and white blood cells, the immune system deploys peptides to fight viruses and other pathogens.

24 Aug 2021

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

New drugs are intended to help stop viral zoonoses - infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

20 Aug 2021

Researchers create a novel strategy for developing an effective TB vaccine

Innovators at Purdue University and Houston Methodist Research Institute have created a novel strategy for developing an effective vaccine for a widespread form of tuberculosis.

20 Aug 2021

Scientists propose innovative method to test the effectiveness of coronavirus medicines

South Ural State University scientists have proposed an innovative method for testing the effectiveness of medicines for coronavirus. According to the researchers, it is necessary to focus on the maximum coincidence of the ligand and the receptor. The results of the work have been published in the highly-rated journal "Molecules"(Q1).

18 Aug 2021

Designing antimalarials with multiple targeting mechanisms of action

Malaria remains a serious global health threat. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance.

18 Aug 2021

Using self-assembled drugs to achieve a breakthrough in cancer therapy

One of the most challenging aspects of cancer treatment is the huge variety of different tumors that can occur with each one potentially requiring a different solution because unfortunately, one drug does not fit all.

17 Aug 2021

Flavonoid-based inhibitors targeting SARS-CoV 3CL protease for the treatment of SARS-CoV-2 infection

A new study has explored a series of potential flavonoid inhibitors targeting 3CL protease of SARS-CoV.

9 Aug 2021

New compound inspired by tapeworm drugs shows two-pronged effectiveness against COVID-19

A group of medications long prescribed to treat tapeworm has inspired a compound that shows two-pronged effectiveness against COVID-19 in laboratory studies, according to a new publication appearing online in the journal ACS Infectious Disease.

9 Aug 2021

Open-access database could speed up repurposing of old drugs as new treatments

Researchers have created a new open-access database of information on drug candidates and how they are metabolized by the body, which could help speed up the repurposing of old drugs as new treatments.

3 Aug 2021

Study paves the way to a new drug design concept

Hydrogen peroxide reacts with copper to produce hydroxyl radicals with strong antibacterial properties. However, this requires high copper concentrations because two copper atoms have to come close together, which occurs by chance.

31 Jul 2021

Researchers identify an unexpected effect for already characterized active substances

Every innovative drug starts with the search for an active substance targeting key players in disease-related processes.

23 Jul 2021

A novel method developed for producing new antibiotics to combat resistant bacteria

Researchers at Children's Hospital of Philadelphia have developed a novel method for producing new antibiotics to combat resistant bacteria.

19 Jul 2021

New compounds can provide a breakthrough in the treatment of neurodegenerative pathologies

Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer's, Parkinson's, and other severe brain pathologies. These substances can provide a breakthrough in the treatment of neurodegenerative pathologies.

19 Jul 2021

Scientists identify existing drugs that may inhibit SARS-CoV-2 virus

The COVID-19 pandemic has caused more than 600,000 deaths in the United States since the start of 2020 and more than 4 million globally.

13 Jul 2021

New approach that uses machine learning could transform drug development

Writing in the July 12, 2021 online issue of Nature Communications, researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval.

12 Jul 2021