Genomics

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Scientists identify new role of important factor in early embryonic development

In collaboration with Stanford University, a working group from MedUni Vienna’s Division of Cell and Developmental Biology, led by Mark Wossidlo, has identified the role of a factor involved in early embryonic development.

20 Mar 2020

Starlings' sleep time affected by night length and moon phase

Researchers of the University of Groningen and the Max Planck Institute have found that starlings sleep five hours less per night during the summer.

19 Mar 2020

Researchers uncover molecular events underlying paternal diet-induced metabolic disorders in children

When parents eat low-protein or high-fat diets it can lead to metabolic disorders in their adult offspring. Now, an international team led by researchers at the RIKEN Cluster for Pioneering Research have identified a key player and the molecular events underlying this phenomenon in mice.

19 Mar 2020

High-throughput screening of AAV vector capsid libraries reveals unexpected insights

Researchers have used high-throughput screening of adeno-associated viral (AAV) vector capsid libraries to maximize the likelihood of obtaining AAV variants with desired properties.

18 Mar 2020

Cannabinoid 1 receptor expression displays sexually dimorphic pattern in the mouse brain

A major challenge in neuroscience lies in understanding how molecular and circuit differences in the brain synergistically contribute to sex differences in behavioral phenotypes. Sex differences in the brain may arise from the identity, distribution and relative abundance of cell types.

17 Mar 2020

Researchers elucidate new mechanism for controlling DNA methylation in cells

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.

17 Mar 2020

Increased competition between males can lead to higher rate of harmful mutations in offspring

Males that face tougher competition for females risk having offspring with a greater number of harmful mutations in their genome than males without rivals.

16 Mar 2020

Researchers develop new kind of CRISPR screen technology to target RNA

CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases.

16 Mar 2020

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

Adaptive immunity is a powerful defense mechanism in vertebrates. A finely tuned interplay of different cell types provides a pathogen-specific immune response to eliminate for example bacteria and viruses.

13 Mar 2020

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

A sperm enters an egg, an embryo develops and eventually a baby is born. But back up a second -- how does the mother's half-genome actually merge with the father's half-genome to form one new human genome?

13 Mar 2020

Researchers reveal nerve circuitry regulating worms' response to changing temperatures

Nagoya University researchers and colleagues have revealed the nerve circuitry regulating the response of a tiny soil worm to changing temperatures.

13 Mar 2020

New nano strategy for 'trapping and zapping' antibiotic resistant genes

It's not enough to take antibiotic-resistant bacteria out of wastewater to eliminate the risks they pose to society. The bits they leave behind have to be destroyed as well.

12 Mar 2020

People want more money, control in exchange for genomic data

Genomic data donated by the public is valuable for the companies that collect it. But a recent survey finds that once people are aware of issues surrounding the use and security of genetic information, people are more concerned about how it might be used and expect to be better compensated for providing it.

11 Mar 2020

Researchers probe how specific genes can impact early brain development

When brains begin developing, there are a lot of moving parts -- and when mutations happen in early neurodevelopment, it can lead to disorders like macrocephaly and autism.

11 Mar 2020

Canine study discovers novel genes associated with hip dysplasia and osteoarthritis

Hip dysplasia, common in both dogs and humans, and associated osteoarthritis are complex disorders influenced by a multitude of genes.

11 Mar 2020

Exploiting careless cancer cells to develop new drugs

Could the ability of cancer cells to quickly alter their genome be used as a weapon against malignant tumors? Researchers at Uppsala University have succeeded in developing a substance that has demonstrated promising results in experiments on both animal models and human cancer cells.

11 Mar 2020

CRISPR-Cas system can be used to effectively target colitis pathogen

Research at North Carolina State University shows that the CRISPR-Cas system can be used to effectively target and eliminate specific gut bacteria, in this case Clostridioides difficile, the pathogen that causes colitis - a chronic, degenerative disease of the colon.

10 Mar 2020

New toolkit to repair DNA breaks linked to aging, cancer and MND discovered

A new 'toolkit' to repair damaged DNA that can lead to aging, cancer and Motor Neurone Disease has been discovered by scientists at the Universities of Sheffield and Oxford.

9 Mar 2020

Preclinical data of Ocugen's OCU400 genetic modifier published in Nature Gene Therapy

Ocugen, Inc., a clinical-stage company focused on discovering, developing and commercializing transformative therapies to treat rare and underserved ophthalmic diseases, announced today the publication in Nature Gene Therapy of preclinical data of nuclear hormone receptor gene NR2E3 as a genetic modifier and therapeutic agent to treat multiple retinal degenerative diseases.

3 Mar 2020

Functioning amyloid found in healthy brain

Scientists from St Petersburg University worked with their colleagues from the St Petersburg branch of the Vavilov Institute of General Genetics.

2 Mar 2020

Genomics

Scientists identify new role of important factor in early embryonic development

Starlings' sleep time affected by night length and moon phase

Researchers uncover molecular events underlying paternal diet-induced metabolic disorders in children

High-throughput screening of AAV vector capsid libraries reveals unexpected insights

Cannabinoid 1 receptor expression displays sexually dimorphic pattern in the mouse brain

Researchers elucidate new mechanism for controlling DNA methylation in cells

Increased competition between males can lead to higher rate of harmful mutations in offspring

Researchers develop new kind of CRISPR screen technology to target RNA

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

Researchers reveal nerve circuitry regulating worms' response to changing temperatures

New nano strategy for 'trapping and zapping' antibiotic resistant genes

People want more money, control in exchange for genomic data

Researchers probe how specific genes can impact early brain development

Canine study discovers novel genes associated with hip dysplasia and osteoarthritis

Exploiting careless cancer cells to develop new drugs

CRISPR-Cas system can be used to effectively target colitis pathogen

New toolkit to repair DNA breaks linked to aging, cancer and MND discovered

Preclinical data of Ocugen's OCU400 genetic modifier published in Nature Gene Therapy

Functioning amyloid found in healthy brain

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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