Genomics

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Genetic risk factor for late-onset Alzheimer's disease has early effects on the brain

A genetic predisposition to late-onset Alzheimer's disease affects how the brains of young adults cope with certain memory tasks.

15 Sep 2020

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Myotonic dystrophy type I is the most common type of adult-onset muscular dystrophy. People with the condition inherit repeated DNA segments that lead to the toxic buildup of repetitive RNA, the messenger that carries a gene's recipe to the cell's protein-making machinery.

14 Sep 2020

Study shows role of pathogens in shaping human evolution

Every human cell harbors its own defenses against microbial invaders, relying on strategies that date back to some of the earliest events in the history of life, researchers report.

10 Sep 2020

Gut microbiota composition and function not related to onset of gestational diabetes

Maternal overweight and obesity increase the risk of gestational diabetes mellitus. Gut microbiota composition has recently been associated with both overweight and a range of metabolic diseases.

9 Sep 2020

Viruses play a key evolutionary role in mammals' ability to reproduce and survive

As the world scrambles to control the growing COVID-19 coronavirus pandemic, new research in Nature Structural & Molecular Biology shows viruses also play a key evolutionary role in mammals' ability to reproduce and survive.

7 Sep 2020

Statistical model uses genomic data to predict a person's risk for esophageal cancer

7 Sep 2020

Study shows how genetic data can be used to prioritize drug targets for complex diseases

An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases.

7 Sep 2020

Activation of fatty acid receptor causes masculinization of Japanese rice fish

A research collaboration based at Kumamoto University (Japan) has found that activation of PPARα, a fatty acid receptor that detects fatty acids in cells and regulates physiological functions, causes masculinization of Japanese rice fish (medaka).

5 Sep 2020

Two researchers from Bielefeld University receive ERC Starting Grants

The European Research Council has awarded ERC Starting Grants to two researchers from Bielefeld University.

5 Sep 2020

CRISPR-based system suppresses genes related to AAV antibody production

Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing sequence or enact a temporary change in its expression, but the body's immune response to AAV can thwart the whole endeavor.

4 Sep 2020

Scientists identify genetic risk factors underlying penicillin allergy

Penicillin, a life-saving medicine, is the most common cause of drug allergy, with clinical manifestations ranging from temporary skin reactions to life-threatening systemic syndromes.

3 Sep 2020

Researchers identify a pattern in cancer’s chromosomal chaos

Researchers at the Francis Crick Institute and the UCL Cancer Institute have identified how different cancers go through some of the same genetic mutations at the same point in their evolution.

3 Sep 2020

Researchers investigate persistence of reproductive cells despite damage from jumping genes

Believe it or not, your genes are 50% parasite, and opportunistic at that. They tend to jump onto sperm and egg cells to replicate in the next generation, a process that can devastate an egg or sperm cell.

1 Sep 2020

Previously overlooked insect shows promise as alternative protein source

With global food demands rising at an alarming rate, a study led by IUPUI scientists has found new evidence that a previously overlooked insect shows promise as alternative protein source: the yellow mealworm.

31 Aug 2020

DNA structure is determined by spatial rules based on specific protein sequences and their order

DNA three-dimensional structure is determined by a series of spatial rules based on particular protein sequences and their order.

28 Aug 2020

Study can help improve rapeseed oil composition

A group of scientists from Skoltech and Pustovoit All-Russian Research Institute of Oil Crops in Krasnodar performed genetic analysis of the Russian rapeseed collection.

28 Aug 2020

Researchers discover genetic link between cattle temperament and autism in humans

A strong association between the genes influencing cattle temperament and autism in humans has been discovered by University of Queensland researchers.

27 Aug 2020

New sequencing approach can detect rare mutation in large number of cells

A sequencing approach can home in on a rare mutation within a large number of cells, revealing implications for CRISPR genome editing and early cancer detection.

27 Aug 2020

New group of Chlamydiae have hydrogen-producing genes that help them survive without oxygen

An international team of researchers has discovered a new group of Chlamydiae - Anoxychlamydiales - living under the ocean floor without oxygen.

27 Aug 2020

Advances in Virus Epigenetics

Growing evidence shows viruses exploit epigenetic processes to control their life cycles but epigentic regulation of viral infections is not fully understood.

From Chromatrap® - Porvair Sciences Ltd 25 Aug 2020

Genomics

Genetic risk factor for late-onset Alzheimer's disease has early effects on the brain

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Study shows role of pathogens in shaping human evolution

Gut microbiota composition and function not related to onset of gestational diabetes

Viruses play a key evolutionary role in mammals' ability to reproduce and survive

Statistical model uses genomic data to predict a person's risk for esophageal cancer

Study shows how genetic data can be used to prioritize drug targets for complex diseases

Activation of fatty acid receptor causes masculinization of Japanese rice fish

Two researchers from Bielefeld University receive ERC Starting Grants

CRISPR-based system suppresses genes related to AAV antibody production

Scientists identify genetic risk factors underlying penicillin allergy

Researchers identify a pattern in cancer’s chromosomal chaos

Researchers investigate persistence of reproductive cells despite damage from jumping genes

Previously overlooked insect shows promise as alternative protein source

DNA structure is determined by spatial rules based on specific protein sequences and their order

Study can help improve rapeseed oil composition

Researchers discover genetic link between cattle temperament and autism in humans

New sequencing approach can detect rare mutation in large number of cells

New group of Chlamydiae have hydrogen-producing genes that help them survive without oxygen

Advances in Virus Epigenetics

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From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

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