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Glucarpidase shows promise in treating kidney toxicity from methotrexate

An FDA-approved medication called glucarpidase could serve as an antidote to kidney toxicity in patients receiving the chemotherapy drug methotrexate (MTX), according to a new study by investigators at Mass General Brigham.

6 Jan 2025

Addressing loneliness in borderline personality disorder treatment

Loneliness is a key driver in the maintenance of borderline personality disorder (BPD), Harvard researchers argue. Thus, many patients cite increased social connection as a primary treatment goal.

6 Jan 2025

New biomarkers may offer a more sensitive approach for monitoring kidney health

Drug-induced kidney injury, or nephrotoxicity, is a common complication in clinical medicine that happens when drugs damage the kidneys.

6 Jan 2025

Anhedonia: The hidden psychological toll of deep endometriosis

Nearly 30% of women with deep endometriosis experience reduced pleasure sensitivity (anhedonia), linked to chronic pelvic pain, highlighting overlooked psychological consequences of this condition.

6 Jan 2025

Fracture Liaison Services crucial for addressing global osteoporosis challenges

A new Perspective article published in the New England Journal of Medicine emphasizes the critical role of Fracture Liaison Services (FLS) in addressing the growing global burden of osteoporosis-related fractures, particularly hip fractures.

6 Jan 2025

DASH Diet earns top spots in 2025 U.S. News & World Report Best Diets Rankings

The Dietary Approaches to Stop Hypertension, or DASH, Diet, developed in part by Pennington Biomedical Research Center scientists, has been recognized as the second-best diet overall and the best heart-healthy diet in the 2025 U.S. News & World Report Best Diets Rankings.

6 Jan 2025

Investigating the impact of CircRNAs on cancer progression and drug resistance

The researcher has given an overview on the regulatory network of extracellular circRNAs in cancer and their impact on cancer drug resistance.

6 Jan 2025

Sugary beverages contribute to millions of diabetes and heart disease cases

A new study from researchers at the Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University, which published in Nature Medicine on January 6, estimates that 2.2 million new cases of type 2 diabetes and 1.2 million new cases of cardiovascular disease occur each year globally due to consumption of sugar-sweetened beverages.

6 Jan 2025

NUS researchers enhance chemotherapy with magnetic field pulses

Researchers at the National University of Singapore (NUS) have developed a non-invasive method to improve the effectiveness of chemotherapy while reducing its harmful side effects.

6 Jan 2025

University of Birmingham receives £3.5 million to study arthritis treatment responses

In recent years treatment with powerful biologic and targeted synthetic therapies has changed the landscape for arthritis, but currently finding the right treatment for each person is a matter of trial and error.

6 Jan 2025

New GFR formula offers better diagnosis of hyperfiltration in elderly patients

Annual health checkups regularly include urine tests that serve several purposes, including checking for symptoms of kidney disease.

6 Jan 2025

ING5 regulates metabolic reprogramming in lung cancer cells

Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes.

6 Jan 2025

Topical immunotherapy clears precancerous skin lesions and reduces cancer risk

Calcipotriol-plus–5-FU therapy activates immune pathways, offering long-lasting protection against squamous cell carcinoma by targeting precancerous lesions.

6 Jan 2025

Do GLP-1 receptor agonists increase the risk of suicide in patients?

A nationwide study confirms GLP-1 RAs pose no short-term psychiatric risk, showing a negative association with suicidal behaviors in high-risk populations.

6 Jan 2025

GPT-4 demonstrates high accuracy in analyzing multilingual medical notes

A study evaluates GPT-4's analysis of medical notes in English, Spanish, and Italian, achieving 79% agreement with physicians on key clinical insights.

6 Jan 2025

Y chromosome’s unexpected impact on aging and disease in men

Loss of the Y chromosome (LOY) in men, a dynamic mutation linked to aging, impairs immune function and increases risks of cancer, Alzheimer’s, and cardiovascular diseases, making it a promising biomarker and therapeutic target.

5 Jan 2025

Study identifies best imaging methods for evaluating brain tumor response in melanoma patients

Raymond Y. Huang, MD, Ph.D., of the Department of Radiology at Brigham and Women's Hospital, is the corresponding author of a paper published in the Journal of Clinical Oncology, "Comparative Analysis of Intracranial Response Assessment Criteria in Patients With Melanoma Brain Metastases Treated With Combination Nivolumab + Ipilimumab in CheckMate 204."

3 Jan 2025

Study reveals major differences between human and mouse PD-1 in cancer research

Since its discovery in the 1990s, "programmed cell death protein 1," or PD-1, has been regarded as a leading target in cancer treatments.

3 Jan 2025

Breakthrough in protein homeostasis offers potential for preventing Alzheimer’s

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis (proteostasis), by which cells maintain the balance and proper functioning of their proteins.

3 Jan 2025

New insights into uncontrollable movements in Parkinson's disease patients

University of Arizona researchers have revealed new insights into one of the most common complications faced by Parkinson's disease patients: uncontrollable movements that develop after years of treatment.

3 Jan 2025