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New biomarker offers hope for early Parkinson’s diagnosis

A misfolded protein facilitates reliable diagnosis even in the early stages of Parkinson’s disease in body fluids.

25 Apr 2025

IL-17A identified as a potential driver of cancer in familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is a hereditary disease which, in addition to a high risk of bowel cancer, also a greatly increased risk of duodenal cancer.

25 Apr 2025

Study finds early signs of dry eye in most young adults

Researchers at Aston University have called for more advice to be given to young people about preventing dry eye disease, after a study carried out in conjunction with Oslo University Hospital and Sørlandet Hospital Trust in Norway found that 90% of participants had at least one sign of the condition in their eyes.

25 Apr 2025

Serum hsa_circ_101555 as a promising biomarker for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) represents the most prevalent malignancy in Egypt and globally. However, non-invasive diagnostic/prognostic biomarkers for early detection of HCC are still lacking. Circular RNAs (circRNAs) are one of the promising biomarkers.

24 Apr 2025

Guilt and shame drive end-of-life treatment decisions in cancer patients

Guilt and shame – not hope for recovery – are among the most common reasons terminally ill cancer patients continue with minimally beneficial treatments at the end of life, according to Rutgers researchers.

24 Apr 2025

New insights into the complex health economics of Alzheimer's disease and related dementias

Value in Health, the official journal of ISPOR-The Professional Society for Health Economics and Outcomes Research, announced today the publication of a special themed section of research papers that provide crucial insights into the complex health economics of Alzheimer's disease and related dementias (ADRD), offering a roadmap for future research and policy as the aging population grows and novel treatments emerge.

24 Apr 2025

Transitioning pancreatic cells show lasting epigenetic cancer traits

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary "memory" of those cancer-linked marks.

24 Apr 2025

Novel cancer immunotherapy approach could complement existing CAR-T treatments

Researchers in South Korea have proposed a novel cancer immunotherapy approach that could complement existing CAR-T (Chimeric Antigen Receptor T-cell) treatments.

24 Apr 2025

AI tools improve detection of key immune structures in melanoma

Researchers from the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) have applied AI-driven processes for detecting tertiary lymphoid structures (TLS) in thousands of digital images of melanoma tumor tissue, significantly enhancing TLS identification and survival predictions for operable stage III/IV patients.

24 Apr 2025

New graph design helps doctors better assess blood pressure

If a picture is worth a thousand words, how much is a graph worth? For doctors trying to determine whether a patient's blood pressure is within normal range, the answer may depend on the type of graph they're looking at.

24 Apr 2025

lncRNAs shape the tumor microenvironment and drive cancer development

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting to influence tumorigenesis, progression, and metastasis.

24 Apr 2025

Manipulating a master regulator prevents tumor growth in mice

A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system's response to cancer.

24 Apr 2025

Common diabetes drug can reduce the pain of people with knee osteoarthritis and obesity

A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, Monash University-led research has found.

24 Apr 2025

Autistic traits do not impact age-related decline in spatial working memory

There is no difference over time in the spatial working memory of older people who have autistic traits and those who are neurotypical, finds a new study led by UCL researchers.

24 Apr 2025

Heart failure patients benefit from medically tailored meals after discharge

A new study, published in BMC Nutrition, demonstrates that providing medically tailored meals (MTM) to patients with heart failure (HF) and malnutrition risk following hospital discharge significantly improves their nutritional status and keeps hospital readmission rates well below local and national averages.

24 Apr 2025

Monoclonal antibody can effectively reverse bleeding complications linked to ticagrelor

An investigational monoclonal antibody called bentracimab can safely and effectively reverse potentially catastrophic bleeding complications linked to ticagrelor, a common drug used to treat patients with acute coronary syndromes, prior heart attack, stroke, and coronary artery disease.

24 Apr 2025

Rethinking stroke prevention for patients with mild carotid narrowing

Ischemic stroke remains one of the leading causes of death and long-term disability worldwide, with narrowing of the carotid artery due to atherosclerosis contributing to up to 30% of all cases.

24 Apr 2025

Both low and moderate-high intensity exercise could help fight against Alzheimer's

Researchers at University of California San Diego and Wake Forest University have found that both low and moderate-high intensity exercise could be valuable tools in the fight against Alzheimer's.

24 Apr 2025

Simple intervention during ER visits lowers blood pressure long term

A simple consultation during unrelated visits to the emergency room can help patients with high blood pressure - "the silent killer" - manage the condition, even before they experience symptoms, according to new research from the University of Illinois Chicago.

24 Apr 2025

Global clinical trial tests two anti-inflammatory drugs for long COVID

Spanning four continents and enrolling hundreds of people, a new clinical trial will test the effectiveness of two anti-inflammatory medicines as potential treatments for long COVID, scientists from Western University and the Schmidt Initiative for Long Covid (SILC) announced today.

24 Apr 2025