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FDA grants orphan drug designation to Ultragenyx UX003 for treatment of MPS 7

Ultragenyx Pharmaceutical Inc., a biotechnology company focused on developing treatments for rare and ultra-rare genetic disorders, today announced that the FDA Office of Orphan Products Development has granted orphan drug designation for UX003 for the treatment of MPS 7.

28 Feb 2012

Viewpoints: Disabled 'disdain' a poisonous meme? Two sides on physician payments issue, letting Mich.'s community colleges train nurses

Disability advocates across the political spectrum strongly supported the 2010 health care reform. They had obvious reasons to do so. The new law provides protections for people with preexisting conditions, regulations to make sure insurers properly cover care for chronic illnesses and expanded coverage for young adults and low-income families. But more is at stake here than factual inaccuracies.

28 Feb 2012

Single dose of Ritalin may raise awareness of mistakes: Study

The study, by Dr Rob Hester from the Department of Psychological Sciences and colleagues at the Queensland Brain Institute, investigated how the brain monitors ongoing behavior for performance errors – specifically failures of impulse control. This study found that a single dose of methylphenidate (Ritalin) results in significantly greater activity in the brain’s error monitoring network and improved volunteers’ awareness of their mistakes.

28 Feb 2012

TAK-875 - an emerging therapy for Type 2 diabetes

In a trial of 426 patients with Type 2 diabetes, TAK-875 reduced blood sugar below a pre-determined level in as much as 48 percent of those receiving it after 12 weeks, compared with 40 percent of those who took glimepiride, the older drug, according to findings published online by The Lancet medical journal. The research was presented in June at the American Diabetes Association’s annual meeting in San Diego.

28 Feb 2012

Stents not more beneficial than medications in stable coronary artery disease: Study

The placement of a stent to repair a narrowed artery in the heart has become routine worldwide. A new analysis of earlier clinical trials shows that inserting a stent has no benefit over standard medical care in treating stable coronary artery disease.

28 Feb 2012

Low levels of omega-3 in blood ‘ups’ risk of dementia and brain aging: Study

Researchers looked at 1,575 adults who averaged 67 years old and had no signs of dementia and had not had a stroke. They were given MRI brain scans and a battery of tests to measure memory and thinking abilities; they also had blood drawn to check the level of docosahexaenoic acid (DHA) or omega-3 fatty acids in their red blood cells. Those with the lowest levels of omega-3s showed signs of accelerated aging. They had lower brain volume, indicating shrinkage comparable to two additional years of aging. Compared with those with the highest blood levels of omega-3s, they scored lower on cognitive tests measuring such things as memory, problem solving, abstract thinking and multi-tasking.

28 Feb 2012

Adolescents more sensitive to effects of sport-related concussions

Research results published in Brain Injury by Universit- de Montr-al neuropsychologist Dave Ellemberg reveal that adolescents are more sensitive to the effects of a sport-related concussion than adults or children.

28 Feb 2012

New guidelines for detection of rheumatic heart disease

The inaugural international guidelines for the diagnosis of rheumatic heart disease (RHD), a disease that affects tens of millions of people worldwide, have today been published by the World Heart Federation in Nature Reviews Cardiology.

28 Feb 2012

DBV receives FDA Fast Track Designation for Viaskin Peanut clinical development program

DBV Technologies announced today that it has received "Fast Track Designation" for the Clinical Development Program of its Viaskin Peanut, a product designed for the treatment by Epicutaneous Immunotherapy (EPIT) of patients with peanut allergy.

28 Feb 2012

CNRS/Inserm researchers discover new family of anti-cancer compounds

A French-Italian team headed by researchers from CNRS and Inserm has discovered a new family of compounds that could make it possible to treat numerous cancers, particularly brain tumors and skin cancers.

28 Feb 2012

Initial stent implantation does not appear to improve outcomes for patients with stable CAD

A meta-analysis of eight previously published clinical trials suggests that initial stent implantation for patients with stable coronary artery disease is not associated with improved outcomes compared with initial medical therapy for prevention of death, nonfatal heart attacks, unplanned revascularization or angina, according to a study published in the Feb. 27 Archives of Internal Medicine, one of the JAMA/Archives journals.

28 Feb 2012

Heat-related deaths in football players triple to nearly three per year between 1994-2009

Heat-related deaths among football players across the country tripled to nearly three per year between 1994 and 2009 after averaging about one per year the previous 15 years, according to an analysis of weather conditions and high school and college sports data conducted by University of Georgia researchers.

28 Feb 2012

Insights into how fructose may contribute to development of obesity, diabetes

A group of scientists from across the world have come together in a just-published study that provides new insights into how fructose causes obesity and metabolic syndrome, more commonly known as diabetes.

28 Feb 2012

Behavioral intervention appears to reduce WC among obese patients

A physical activity and diet program implemented by health educators in physician offices appears to be associated with modest reductions in waist circumference among obese patients, according to a report published Online First by Archives of Internal Medicine, one of the JAMA/Archives journals.

28 Feb 2012

Telephone-based counseling program does not improve osteoporosis medication adherence

Telephone motivational counseling sessions did not result in a statistically significant improvement in adherence to an osteoporosis medication regimen, according to a report published Online First by Archives of Internal Medicine, one of the JAMA/Archives journals.

28 Feb 2012

Journal of Cardiac Failure explains new recommendations for CRT use

Based on a review of the latest evidence, the Guidelines Committee of the Heart Failure Society of America now recommends that the use of cardiac resynchronization therapy (CRT) be expanded to a larger group of patients with mild heart failure symptoms.

28 Feb 2012

AF strong predictor of cognitive and functional decline in older people at risk of heart disease

An irregular heartbeat - atrial fibrillation - is a strong predictor of cognitive decline and the loss of independence in daily activities in older people at risk of cardiovascular disease, according to a study in CMAJ.

28 Feb 2012

Gedeon Richter and Forest Labs' cariprazine Phase III trials on schizophrenia meet primary endpoint

Forest Laboratories, Inc. and Gedeon Richter Plc. today announced positive top-line results in 2 Phase III clinical trials of cariprazine (RGH-188) for the treatment of acute exacerbation of schizophrenia.

28 Feb 2012

New approaches may increase effectiveness of SCS for severe back pain

New approaches to electrical stimulation—using an implanted device with three columns of electrodes—may increase the effectiveness of spinal cord stimulation (SCS) for severe back pain, suggests a study in the March issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

28 Feb 2012

Childhood adversity may lead to epigenetic changes in glucocorticoid receptor gene

In a look at how major stressors during childhood can change a person's biological risk for psychiatric disorders, researchers at Butler Hospital have discovered a genetic alteration at the root of the association.

28 Feb 2012

Medical Condition News

FDA grants orphan drug designation to Ultragenyx UX003 for treatment of MPS 7

Viewpoints: Disabled 'disdain' a poisonous meme? Two sides on physician payments issue, letting Mich.'s community colleges train nurses

Single dose of Ritalin may raise awareness of mistakes: Study

TAK-875 - an emerging therapy for Type 2 diabetes

Stents not more beneficial than medications in stable coronary artery disease: Study

Low levels of omega-3 in blood ‘ups’ risk of dementia and brain aging: Study

Adolescents more sensitive to effects of sport-related concussions

New guidelines for detection of rheumatic heart disease

DBV receives FDA Fast Track Designation for Viaskin Peanut clinical development program

CNRS/Inserm researchers discover new family of anti-cancer compounds

Initial stent implantation does not appear to improve outcomes for patients with stable CAD

Heat-related deaths in football players triple to nearly three per year between 1994-2009

Insights into how fructose may contribute to development of obesity, diabetes

Behavioral intervention appears to reduce WC among obese patients

Telephone-based counseling program does not improve osteoporosis medication adherence

Journal of Cardiac Failure explains new recommendations for CRT use

AF strong predictor of cognitive and functional decline in older people at risk of heart disease

Gedeon Richter and Forest Labs' cariprazine Phase III trials on schizophrenia meet primary endpoint

New approaches may increase effectiveness of SCS for severe back pain

Childhood adversity may lead to epigenetic changes in glucocorticoid receptor gene

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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