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New RAGE inhibitor shows promise against Alzheimer's

Researchers have taken another crack at a promising approach to stopping Alzheimer's disease that encountered a major hurdle last year. In research published this week in the Journal of Clinical Investigation, scientists have developed a compound that targets a molecular actor known as RAGE, which plays a central role in mucking up the brain tissue of people with the disease.

15 Mar 2012

Beating coronary artery bypass surgery may carry an increased likelihood of death

Coronary artery bypass surgery performed whilst the heart is still beating may carry an increased likelihood of death, according to a systematic review by Cochrane researchers.

15 Mar 2012

People with RBD more likely to develop Parkinson's, MCI

People with symptoms suggesting rapid eye movement sleep behavior disorder, or RBD, have twice the risk of developing mild cognitive impairment (MCI) or Parkinson's disease within four years of diagnosis with the sleep problem, compared with people without the disorder, a Mayo Clinic study has found.

15 Mar 2012

AT-1001 shows promise in treating drug addiction

In preclinical studies, researchers at SRI International and Astraea Therapeutics have recently evaluated the role of a new drug receptor target that shows promise for the treatment of drug addiction.

15 Mar 2012

NCAA grant to kick off long-term study of concussion, other head injuries in athletes

A grant from the NCAA will kick off a groundbreaking, long-term study of concussion and other head injuries among athletes, led by University of Michigan researchers and their colleagues around the country.

15 Mar 2012

Exercise training can reduce worry symptoms among GAD patients

This study demonstrates that exercise training, including resistance exercise training, is a feasible, low-risk treatment that can potentially reduce worry symptoms among generalized anxiety disorder (GAD) patients and may be an effective adjuvant, short-term treatment or augmentation for GAD.

15 Mar 2012

Researchers identify epigenetic signatures within reprogrammed skin cells

A research team has identified epigenetic signatures, markers on DNA that control transient changes in gene expression, within reprogrammed skin cells.

15 Mar 2012

New experimental technique can produce cells with specific functions

Researchers at the RIKEN Omics Science Center (OSC) have successfully developed and demonstrated a new experimental technique for producing cells with specific functions through the artificial reconstruction of transcriptional regulatory networks. As an alternative to induced pluripotent stem cells, the technique promises to enable faster and more efficient production of functional cells for use in cancer therapy and a variety of other areas.

15 Mar 2012

One in four HIV patients have been sexually abused as a child

One in four HIV patients was found to have been sexually abused as a child, according to a two-year Duke University study of more than 600 HIV patients. Traumatic childhood experiences were also linked to worse health outcomes among these patients, who are aged 20 to 71.

15 Mar 2012

Dietary cadmium may lead to increased risk of breast cancer

Dietary cadmium, a toxic metal widely dispersed in the environment and found in many farm fertilizers, may lead to an increased risk of breast cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

15 Mar 2012

Low-carb, reduced glycemic load and portion-controlled diets effective for obese children

A new study of three diets with obese children shows that all diets are effective in managing weight but that a reduced glycemic load diet - one that accounts for how many carbs are in the food and how much each gram of carbohydrate raises blood glucose levels - may be most promising.

15 Mar 2012

Researchers discover how Salmonella thrives in the digestive tract

UC Irvine researchers have discovered how Salmonella, a bacterium found in contaminated raw foods that causes major gastrointestinal distress in humans, thrives in the digestive tract despite the immune system's best efforts to destroy it.

15 Mar 2012

Cadherin-23 might play a role in earliest stages of breast cancer metastasis

Rensselaer Polytechnic Institute Biologist Lee Ligon has found a previously unknown connection between breast cancer tumor cells and the surrounding healthy tissue. The results provide new information on the earliest stages of breast cancer metastasis.

15 Mar 2012

Teva commences commercial launch of Escitalopram Oxalate Tablets

Teva Pharmaceutical Industries Ltd. announced today that it has commenced commercial launch of Escitalopram Oxalate Tablets, the Company's generic version of Forest Laboratories' depression and generalized anxiety disorder treatment, Lexapro Tablets.

15 Mar 2012

Specialised cancer centers may improve survival rates for patients

Survival rates for cancer patients may be improved by treatment in specialised cancer centers, according to Cochrane researchers. In a review of recent studies, they found that women diagnosed with gynaecological cancer lived longer when treated in specialist compared to non-specialist units.

15 Mar 2012

Scientists identify new compound that quickly kills HCC cells

Scientists have identified a new compound that rapidly kills hepatocellular carcinoma (HCC) cells, the most common form of liver cancer and fifth most common cancer worldwide, while sparing healthy tissue.

15 Mar 2012

New rule ensuring equal access for ESRD patients receives DPC praise

Dialysis Patient Citizens (DPC), the nation's largest patient-led organization representing dialysis patients, applauded the Administration for taking steps to solidify a key provision that will ensure end stage renal disease (ESRD) patients have equal access to private coverage as Affordable Care Act reforms are implemented.

14 Mar 2012

Endoscopic transgastric necrosectomy associated with lower risk of major complications

In a small, preliminary trial, patients with infected necrotizing pancreatitis who received a less-invasive procedure, endoscopic transgastric necrosectomy, had an associated lower risk of major complications and death compared to patients who had surgical necrosectomy, according to a study in the March 14 issue of JAMA.

14 Mar 2012

Mutated ATRX gene associated with advanced-stage neuroblastoma

Certain mutations of the gene ATRX were associated with age at diagnosis in children and young adults with advanced-stage neuroblastoma, a cancer that grows in parts of the nervous system, according to a study in the March 14 issue of JAMA.

14 Mar 2012

Scientists grow rudimentary retina structure from blood cells

For the first time, scientists at the University of Wisconsin-Madison have made early retina structures containing proliferating neuroretinal progenitor cells using induced pluripotent stem (iPS) cells derived from human blood.

14 Mar 2012