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Crick researchers identify key Y chromosome genes influencing sperm development

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice.

23 Jan 2025

Boosting BCL6 may counteract muscle loss from GLP-1 medications

About one in eight adults in the United States has tried or currently uses a GLP-1 medication, and a quarter of those users cite weight loss as their main goal.

23 Jan 2025

New approach to treating ependymoma with leukemia drug

Rakesh Jain PhD, Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior author of a new study in PNAS, Targeting EPHB2/ABL1 Restores Anti-Tumor Immunity in Preclinical Models of Ependymoma.

23 Jan 2025

EU-funded Vigilant network aims to develop broad-spectrum antiviral drugs

Pandemics threaten both human health and the global economy. Vaccines are an essential part of the fight against pandemics, but they are only available months after the outbreak

23 Jan 2025

Microplastics in the bloodstream may pose hidden risks to brain health

Trapped immune cells laden with microplastics starve the brain of oxygen—mouse study links vascular blockages to memory loss and motor deficits, with lingering risks even after symptoms fade.

23 Jan 2025

New AI software could speed up drug development

The discovery and development of drugs in pharmacological research – including the risk assessment of active substances in the early phase of drug development – still largely relies on animal experiments.

23 Jan 2025

Non-industrialized diet improves health and reduces disease risk

Researchers have found that a newly developed diet inspired by the eating habits of non-industrialised societies can significantly reduce the risk of a number of chronic diseases – and are to share recipes with the public.

23 Jan 2025

Researchers map genetic differences across children with Wilms tumor

Genetically tailored treatment plans for children with a type of kidney cancer could help provide the most effective care while minimizing side effects as much as possible.

23 Jan 2025

Study links chemesthetic sensitivity to food preferences and consumption

Oral chemesthesis, or chemically induced tactile sensation in the mouth area, affects the consumption and recalled pleasantness of certain foods and drinks, such as chilli sauce and alcoholic beverages.

23 Jan 2025

What causes behavioral side effects in popular weight loss drugs?

The study of GLP1R variants shows associations with cardiometabolic traits and behavioral changes, highlighting indirect effects of GLP1RA on mental health.

23 Jan 2025

AGA releases updated guidelines on hepatitis B reactivation in patients on immunosuppressive drugs

The American Gastroenterological Association (AGA) has unveiled an updated clinical practice guideline in Gastroenterology addressing the prevention and management of hepatitis B virus reactivation (HBVr) in patients on immunosuppressive drugs.

23 Jan 2025

New technology tracks millions of cells simultaneously during organ development

Thanks to a new technology called Moscot ("Multi-Omics Single-Cell Optimal Transport"), researchers can now observe millions of cells simultaneously as they develop into a new organ-for example, a pancreas.

23 Jan 2025

Study reveals potential drug links to Dementia risk

Findings from a large-scale review indicate certain medications may influence dementia risk, offering insights for prevention and drug repurposing strategies.

23 Jan 2025

New method enables simultaneous multi-color imaging with bioluminescent proteins

Imaging live cells with fluorescent proteins has long been a crucial technique for understanding cellular behavior. While bioluminescent proteins offer several advantages over fluorescent proteins, the limited availability of color variants has made it difficult to observe multiple targets simultaneously.

23 Jan 2025

New diagnostic device could enable at-home early bladder cancer detection

Innovative fluorescence-based diagnostic system identifies early-stage bladder cancer with 90% accuracy, utilizing untreated urine samples for at-home testing.

23 Jan 2025

New technique identifies SARS-CoV-2 in blood and other fluids with high sensitivity

Investigators from Mass General Brigham have found that a method originally designed for cancer detection can also identify and monitor even tiny amounts of SARS-CoV-2 intact viral particles in blood and other fluids from patients with acute COVID-19 infections, creating the potential for guiding future treatment of patients.

22 Jan 2025

Maternal vitamin D deficiency may accelerate fetal aging and impact newborn health

Maternal vitamin D deficiency during pregnancy is linked to accelerated epigenetic gestational age in infants at birth, suggesting improper fetal development influenced by low vitamin D levels. The study also found associations between maternal age, birth height, and epigenetic aging, though cord blood vitamin D showed no significant impact.

22 Jan 2025