Molecular & Structural Biology

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The role of self-extracellular nucleic acids in neuroinflammation

Researchers explore the role of self-extracellular nucleic acids in diseases like stroke, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease.

14 Aug 2023

Exploring molecular mechanisms and genetic dysregulation in aging and age-associated diseases

Researchers review existing data on the molecular basis of senescence and neurodegeneration in age-related brain diseases.

10 Aug 2023

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

Mitochondrial protein structure activates cell's integrated stress response

Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health.

8 Aug 2023

Unexpected link between pure mathematics and genetics discovered

An interdisciplinary team of mathematicians, engineers, physicists, and medical scientists have uncovered an unexpected link between pure mathematics and genetics, that reveals key insights into the structure of neutral mutations and the evolution of organisms.

8 Aug 2023

Understanding variations in SARS-CoV-2 evolution and clearance by immunodeficiency status

Researchers describe the virological range of persistent SARS-CoV-2 infection in immunosuppressed individuals.

7 Aug 2023

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Researchers investigate whether M2 macrophage-derived exosomes could prevent inflammation-associated damage during sepsis.

7 Aug 2023

Deep learning improves protein design by 10x

The key to understanding proteins -; such as those that govern cancer, COVID-19, and other diseases -; is quite simple. Identify their chemical structure and find which other proteins can bind to them. But there's a catch.

3 Aug 2023

Cryo-EM structures and functions of potent bispecific antibodies against multiple Omicron sublineages

Researchers characterizes the structures and functions of potent bispecific antibodies against multiple Omicron subvariants using Cryo-EM.

3 Aug 2023

Scientists develop breakthrough technology for detecting protein modifications

A team of scientists led by the University of Oxford have achieved a significant breakthrough in detecting modifications on protein structures.

1 Aug 2023

Study reveals internal structure of polyelectrolyte complexes for the first time

For years, we've known that a special kind of molecular assembly known as a "polyelectrolyte complex" helps your cells keep themselves organized.

31 Jul 2023

The essential role of the MPL36 protein in leptospirosis

The Leptospira membrane protein L36 (MPL36) is essential for its pathogenesis.

31 Jul 2023

Cryo-EM study elucidates 3D structure and molecular mechanism of platelet drug transporter

A research team led by Prof. CHEN Yuxing and Prof. ZHOU Cong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) recently utilized single-particle cryogenic electron microscopy (cryo-EM) to decipher the 3D structure and molecular mechanism of the platelet drug transporter ABCC4.

28 Jul 2023

Scientists map 3D structure of kappa opioid receptor

Opioids remain the most potent and effective pain relievers in medicine, but they're also among the most addictive drugs that can halt a person's ability to breathe during an overdose -; which can be deadly.

27 Jul 2023

New protein-based nano-switches could lead to faster, more accurate diagnostic tests

QUT researchers have developed a new approach for designing molecular ON-OFF switches based on proteins which can be used in a multitude of biotechnological, biomedical and bioengineering applications.

27 Jul 2023

Diagnosis of rare inherited metabolic condition in a Sumatran orangutan

Researchers from Indiana University School of Medicine have diagnosed a Sumatran Orangutan at the Indianapolis Zoo with a rare genetic disease called Alkaptonuria.

27 Jul 2023

Study identifies specific genetic variants that affect the skeletal form and ties a major evolutionary facet of human anatomical change to pathogenesis

Researchers evaluate imaging information and characterize skeletal proportions to assess the genetic root of these traits and their connections to each other.

26 Jul 2023

Molecular & Structural Biology

The role of self-extracellular nucleic acids in neuroinflammation

Exploring molecular mechanisms and genetic dysregulation in aging and age-associated diseases

NLRP3 inflammasome plays a role in podocyte aging

Mitochondrial protein structure activates cell's integrated stress response

Unexpected link between pure mathematics and genetics discovered

Understanding variations in SARS-CoV-2 evolution and clearance by immunodeficiency status

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Deep learning improves protein design by 10x

Cryo-EM structures and functions of potent bispecific antibodies against multiple Omicron sublineages

Scientists develop breakthrough technology for detecting protein modifications

Study reveals internal structure of polyelectrolyte complexes for the first time

The essential role of the MPL36 protein in leptospirosis

Cryo-EM study elucidates 3D structure and molecular mechanism of platelet drug transporter

Scientists map 3D structure of kappa opioid receptor

New protein-based nano-switches could lead to faster, more accurate diagnostic tests

Diagnosis of rare inherited metabolic condition in a Sumatran orangutan

Study identifies specific genetic variants that affect the skeletal form and ties a major evolutionary facet of human anatomical change to pathogenesis

Cervical fibroblasts in cervical insufficiency patients show impaired responses to progesterone

Study offers a comprehensive analysis of bacterial and fungal alterations in COVID-19

Researchers discover how ribosomes regulate protein production

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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