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Study: Early benefit assessment of new drugs within the framework of AM-NOG procedure

"The AMNOG procedure has passed its first practical test. It is practicable and can also be implemented in detail", emphasized IQWiG's Director Jürgen Windeler in October 2011, when the Institute had published its first early benefit assessment within the framework of the AM-NOG procedure (AMNOG = Act on the Reform of the Market for Medicinal Products).

22 Mar 2021

Researchers investigate the effect of COVID-19 vaccines on residents of long-term care homes

Long-term care homes have been at the epicenter of the COVID-19 pandemic in Canada, with 70 percent of COVID-19 deaths having occurred in long-term care or nursing homes.

19 Mar 2021

New drug regimen is safe and effective in children with cystic fibrosis

An international, open-label Phase 3 study, co-led by Susanna McColley, MD, from Ann & Robert H. Lurie Children's Hospital of Chicago, found that a regimen of three drugs (elexacaftor/tezacaftor/ivacaftor) that targets the genetic cause of cystic fibrosis was safe and effective in 6-11-year-olds with at least one copy of F508del mutation in the CFTR gene, which is estimated to represent almost 90 percent of the cystic fibrosis population in the United States.

19 Mar 2021

Mass vaccination needed to protect against future resurgences of COVID-19

The first long-term seroprevalence study of residents in Wuhan, China, has found that 6.9% of people in the city had antibodies against COVID-19 in April 2020, and 82% of these people had an asymptomatic infection.

19 Mar 2021

Lower dose of tamoxifen may reduce risk of breast cancer

While the drug tamoxifen reduces the risk of developing breast cancer and prevents recurrence, the side-effects cause many women to discontinue their treatment.

19 Mar 2021

Study finds link between low dose aspirin and decreased COVID-19 severity, death

George Washington University researchers found low dose aspirin may reduce the need for mechanical ventilation, ICU admission and in-hospital mortality in hospitalized COVID-19 patients.

17 Mar 2021

Newly identified drugs can help treat oral and esophageal carcinomas

Discovering and treating tumors before they spread throughout the body is key for cancer patients to achieve positive outcomes. When tumor cells spread, which is known as metastasis, they can take over other organs and lead to death.

17 Mar 2021

Study: 94% of older adults prescribed fall-risk-increasing drugs

Nearly every older adult was prescribed a prescription drug that increased their risk of falling in 2017, according to new University at Buffalo research.

16 Mar 2021

Janssen’s vaccine added to list of safe, effective tools against COVID-19

The World Health Organization (WHO) today listed the COVID-19 vaccine Ad26.COV2.S, developed by Janssen (Johnson & Johnson), for emergency use in all countries and for COVAX roll-out. The decision comes on the back of the European Medicines Agency (EMA) authorization, which was announced yesterday.

16 Mar 2021

Online platforms can increase drug overdose

HSE University researchers together with specialists from the Humanitarian Action Charitable Fund (St. Petersburg) and the University of Michigan School of Public Health (USA) studied the specifics of remote work with Russian people who use drugs to reduce the harm of drug use.

16 Mar 2021

Researchers find no evidence to suggest a link between beta blockers and depression

Drugs such as beta-adrenergic antagonists (beta blockers) have been linked to a range of adverse effects, including depression.

15 Mar 2021

The role of nanotechnology in the fight against COVID-19

Appearing in the journal Nanomedicine, the review summarized all the exciting advances made using diverse nanomaterials (polymeric, inorganic self-assembling materials and peptide-based) towards COVID-19 prevention, diagnosis and therapy.

15 Mar 2021

To extract more doses per vial, vaccinators put squeeze on FDA to relax vaccine handling advice

President Joe Biden has promised enough covid vaccine to immunize every willing adult by June 1. But right now, the gap between supply and demand is so dramatic that vaccinators are discovering ways to suck the final drops out of each vaccine vial — if federal regulators will let them.

12 Mar 2021

Tailored approach is required to fight antibiotic resistance

The global battle against antibiotic resistance can only succeed if local contexts are taken into account. "A tailored approach is needed in each country," says Heiman Wertheim of Radboud university medical center. "There is no "one-size-fits-all' solution."

12 Mar 2021

COVID-19 mRNA vaccines can reduce risk of asymptomatic COVID-19 infection

Ten days after receiving a second dose of a messenger RNA, or mRNA, vaccine for COVID-19, patients without COVID-19 symptoms are far less likely to test positive and unknowingly spread COVID-19, compared to patients who have not been vaccinated for COVID-19.

12 Mar 2021

Triglyceride-lowering medication may lower stroke risk in people with heart disease

Taking the triglyceride-lowering medication icosapent ethyl cut the risk of stroke by an additional 36% in people at increased risk of cardiovascular disease who already have their bad cholesterol levels under control using statin medications, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021.

11 Mar 2021

Sharp declines in opioid production costs could reduce the price per dose

The legalization of cannabis and the arrival of nonmedical fentanyl are fundamentally changing drug markets in North America.

11 Mar 2021

Lower dose of ketamine is as effective as the standard dose to treat pain in adults

A recent Loyola Medicine study found that reducing the standard dose of IV-administered ketamine in half is as effective as the larger, standard dose in reducing pain in adults.

10 Mar 2021

Pfizer’s newest vaccine plant has persistent mold issues, history of recalls

Pfizer's management knew last year there was "a mold issue" at the Kansas facility now slated to produce the drugmaker's urgently needed covid-19 vaccine, according to a Food and Drug Administration inspection report.

10 Mar 2021

How likely is SARS-CoV-2 reinfection?

The coronavirus disease 2019 (COVID-19) pandemic has already caused over 117.6 million confirmed cases the world over. Yet, researchers debate the exact incidence of reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19’s causative pathogen.

10 Mar 2021