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Researchers aim to improve medical treatment for people with insect venom allergy

A team of researchers has elucidated individual profiles of allergy reactivity in patients that are not protected after treatment with immunotherapy. The aim is to improve medical treatment of people who are allergic to insect stings.

21 Jun 2016

Fixed-dose combination of sacubitril and valsartan for heart failure shows differing added benefit

The fixed-dose combination of sacubitril and valsartan (trade name: Entresto) has been approved since November 2015 for adults with symptomatic chronic heart failure with reduced pump function.

21 Jun 2016

Long-term opioid therapy may not be effective to manage pain in sickle cell disease patients

In a small study looking at pain assessments in adults with sickle cell disease, researchers at Johns Hopkins says overall, those treated long-term with opioids often fared worse in measures of pain, fatigue and curtailed daily activities than those not on long-term opioids.

21 Jun 2016

AF patients at risk for stroke mostly treated with aspirin-only prescription instead of blood thinners

Researchers at University of California San Diego School of Medicine and University of California, San Francisco School of Medicine report that more than 1 in 3 atrial fibrillation (AF) patients at intermediate to high risk for stroke are treated with aspirin alone, despite previous data showing this therapy to be inferior to blood thinners.

21 Jun 2016

Fractional dosing approach could be used to control yellow fever outbreaks during vaccine shortages

The yellow fever vaccine given as one fifth of the regular dose could be used to control an outbreak in case of vaccine shortages.

20 Jun 2016

TUM researchers uncover molecular mechanism of thalidomide

In the 1950s, thalidomide (Contergan) was prescribed as a sedative drug to pregnant women, resulting in a great number of infants with serious malformations. Up to now, the reasons for these disastrous birth defects have remained unclear.

20 Jun 2016

Watchman device for irregular heart rhythms may be preferable to standard blood thinning medications

A new study by a Yale researcher may support the use of a device for patients suffering from irregular heart rhythms.

17 Jun 2016

Statins can lower infection risk by 58% in stroke patients

A Washington State University researcher has found that statin drugs can dramatically lower the risk of infections in stroke patients.

17 Jun 2016

NPS MedicineWise urges Australians to stop expecting antibiotics for colds and flu

With new findings launched today showing that antimicrobial use in the community in Australia is higher than in England, Canada, Norway, Denmark, Sweden and the Netherlands—and that the number of antimicrobials being prescribed in Australia continues to grow—NPS MedicineWise is again urging Australians to stop expecting antibiotics for viruses such as colds and flu.

17 Jun 2016

S1P1R variation may cause differential patient responses to fingolimod treatment

Multiple sclerosis (MS) is an autoimmune disorder that results in demyelination of neurons. The FDA-approved drug fingolimod (Gilenya, FTY-720) modulates signaling by the bioactive lipid sphingosine-1-phosphate (S1P), which is linked to MS pathogenesis.

16 Jun 2016

New research paves way for potential notch-based anticancer therapeutics

A recent study led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, in collaboration with the Univerity of Maryland School of Pharmacy and StemSynergy Therapeutics, Inc., has identified a small-molecule inhibitor of the Notch pathway, paving the way for a potential new class of personalized cancer medicines.

16 Jun 2016

TSRI scientists develop novel technique for finding drug candidates

Scientists at The Scripps Research Institute have developed a powerful new method for finding drug candidates that bind to specific proteins.

16 Jun 2016

New analytical technology could improve cancer treatment by establishing ideal dosing regimens

University of Oklahoma researchers will apply a new analytical technology that could ultimately provide a powerful tool for improved treatment of cancer patients in Oklahoma and beyond. Using mass spectrometry, an analytical instrument for sensitive detection and accurate

15 Jun 2016

Prospective biobank studies with genetic data can help improve drug development, reduce costs

With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?

15 Jun 2016

Already-approved drugs can fight apoptosis evasion in cancer

Cancer cells don't die when they're supposed to. Animal and human bodies follow an orderly process of birthing new cells and killing old ones. But cancer cells escape programmed cell death, called apoptosis, and multiply uncontrollably.

15 Jun 2016

Study ignores possibility that drugs, chemicals affect sexes differently

Many of the medicines we take were only ever tested on men during clinical studies. This poses a distinct danger that females are receiving suboptimal care—and that treatments specifically benefiting women are going undiscovered.

15 Jun 2016

Maternal SRI treatment may cause microscopic changes in fetal brain structure

A new Finnish study shows that fetal exposure to commonly used SRI drugs may affect brain activity in newborns. The researchers suggest that the effects of drugs on fetal brain function should be assessed more carefully.

15 Jun 2016

Cranberries can reduce symptomatic UTIs and avoid chronic suppressive antibiotics

Today leading experts on infectious disease and urinary tract infections (UTIs) will gather in London to discuss the alarming state of antibiotic resistance, and present findings from a landmark study that conclusively shows that cranberries can be a nutritional approach to reducing symptomatic UTIs, and as a result, may be a useful strategy to decrease worldwide use of antibiotics.

15 Jun 2016

Immunotherapy drugs given after chemotherapy may benefit ovarian cancer patients

Women with advanced ovarian cancer may benefit more from immunotherapy drug treatments if they are given straight after chemotherapy, according to a new study published in Clinical Cancer Research today.

15 Jun 2016

Blood pressure medications can lower stroke, heart attack risk in patients with end-stage renal disease

Two classes of blood pressure medications, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), are associated with a 16% lower risk of strokes, heart attacks and death in patients with end-stage renal disease who are undergoing peritoneal dialysis, a new study in the journal, Nephrology Dialysis Transplantation, reports.

15 Jun 2016

Pharmaceutical News

Researchers aim to improve medical treatment for people with insect venom allergy

Fixed-dose combination of sacubitril and valsartan for heart failure shows differing added benefit

Long-term opioid therapy may not be effective to manage pain in sickle cell disease patients

AF patients at risk for stroke mostly treated with aspirin-only prescription instead of blood thinners

Fractional dosing approach could be used to control yellow fever outbreaks during vaccine shortages

TUM researchers uncover molecular mechanism of thalidomide

Watchman device for irregular heart rhythms may be preferable to standard blood thinning medications

Statins can lower infection risk by 58% in stroke patients

NPS MedicineWise urges Australians to stop expecting antibiotics for colds and flu

S1P1R variation may cause differential patient responses to fingolimod treatment

New research paves way for potential notch-based anticancer therapeutics

TSRI scientists develop novel technique for finding drug candidates

New analytical technology could improve cancer treatment by establishing ideal dosing regimens

Prospective biobank studies with genetic data can help improve drug development, reduce costs

Already-approved drugs can fight apoptosis evasion in cancer

Study ignores possibility that drugs, chemicals affect sexes differently

Maternal SRI treatment may cause microscopic changes in fetal brain structure

Cranberries can reduce symptomatic UTIs and avoid chronic suppressive antibiotics

Immunotherapy drugs given after chemotherapy may benefit ovarian cancer patients

Blood pressure medications can lower stroke, heart attack risk in patients with end-stage renal disease

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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