Epigenetics News and Research

Latest Epigenetics News and Research

People with SIRT1 genetic variation more likely to develop vibration-induced white finger disease

Vibration-induced white finger disease (VWF) is caused by continued use of vibrating hand held machinery (high frequency vibration >50 Hz), and affects tens of thousands of people. New research published in BioMed Central's open access journal Clinical Epigenetics finds that people with a genetic polymorphism (A2191G) in sirtuin1 (SIRT1), a protein involved in the regulation of endothelial NOS (eNOS), are more likely to suffer from vibration-induced white finger disease.

1 Oct 2012

Autism Speaks announces new round of research grants

Autism Speaks, the world's leading autism science and advocacy organization, today announced the awarding of new research grants totaling nearly $5 million. "Autism Speaks is committed to continuing our research which has tremendous potential to increase our understanding of autism and addressing the needs of individuals with autism," said Autism Speaks Co-founder Bob Wright, "and we are grateful to the donors who make this research possible."

29 Sep 2012

DNp63a protein employs epigenetics to keep cancer cells alive

Squamous cell carcinoma (SCC) is diagnosed in about 700,000 people in the United States every year. Commonly contributing to SCC is a protein called DNp63a - it goes abnormally high and the ability of a patient's body to kill cancer cells goes abnormally low. In many cases of SCC, it's just that simple. And science thought the function of DNp63a was simple, as well: the tumor suppressor gene p53 is responsible for recognizing and killing cancer cells, and in SCC, it's usually inactivated. It looked like high DNp63a repressed p53, made SCC.

27 Sep 2012

Researchers discover path to identify why genetic variants increase breast cancer risk

Cancer researchers studying 44 known genetic variants associated with breast cancer have found the way to identify why they increase cancer risk, opening the door to future therapeutic applications based on personalized medicine.

25 Sep 2012

PAM50 potentially simplifies underlying breast tumor biology

On September 23, researchers published online in the journal Nature a study of the molecular biology of breast cancer, using the intrinsic subtypes as defined by the PAM50 gene signature as an organizing framework for analyzing genomic and proteomic aberrations. This landmark study both underscores the emergence of the intrinsic subtypes as a powerful taxonomy of breast cancer in research, and PAM50's role as the gold standard for categorizing breast cancer by subtype.

From NanoString Technologies 25 Sep 2012

Study on epigenetics link of PTSD and respiratory disease in 9/11 responders

The "Epigenetics Link of PTSD and Respiratory Disease in 9/11 Responders" study is the first to investigate the association between genetic changes and the development of both conditions in the 9/11 responder patient population. Approximately 500 patients treated at the LI-CCE for both conditions will be evaluated during the two-year study.

24 Sep 2012

Researchers identify gene linked to common cause of lower back pain

Researchers at King's College London have for the first time identified a gene linked to age-related degeneration of the intervertebral discs in the spine, a common cause of lower back pain.

24 Sep 2012

Genome-wide epigenomic screening can pinpoint thyroid disease-associated variants

Genome-wide epigenomic screening can pinpoint disease-associated variants and identify novel genetic-epigenetic interactions in autoimmune thyroid diseases, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association (ATA) in Québec City, Québec, Canada.

24 Sep 2012

Maternal choline intake could essentially change fetal genetic expression into adulthood

Just as women are advised to get plenty of folic acid around the time of conception and throughout early pregnancy, new research suggests another very similar nutrient may one day deserve a spot on the obstetrician's list of recommendations.

24 Sep 2012

What moms eat before pregnancy affects children epigenetically

Everyone knows that what mom eats when pregnant makes a huge difference in the health of her child. Now, new research in mice suggests that what she ate before pregnancy might be important too. According to a new research report published online in The FASEB Journal, what a group of female mice ate-before pregnancy-chemically altered their DNA and these changes were passed to her offspring. These DNA alterations, called "epigenetic" changes, drastically affected the pups' metabolism of many essential fatty acids.

21 Sep 2012

Scientists identify unique molecular signature in iPSCs that show promise in regenerative medicine

Salk scientists have identified a unique molecular signature in induced pluripotent stem cells (iPSCs), "reprogrammed" cells that show great promise in regenerative medicine thanks to their ability to generate a range of body tissues.

20 Sep 2012

Modifying fat intake during pregnancy benefits children regardless of mother's size

If you are overweight and pregnant, your baby isn't destined to a life of obesity after all, according to a new research report published online in The FASEB Journal. In the report, a team of U.S. scientists show that modifying fat intake during pregnancy to a moderate level is enough to benefit the child regardless of the mother's size.

17 Sep 2012

ICREA researcher updates latest findings in applied epigenetics

The research team led by Manel Esteller, director of the Cancer Epigenetics and Biology Program at the Bellvitge Biomedical Research Institute (IDIBELL), professor of genetics at the University of Barcelona and ICREA researcher, has updated the latest findings in applied epigenetics in a review paper published in Nature Reviews Genetics.

13 Sep 2012

NDC to advance study and treatment of Alzheimer's and other neurodegenerative diseases

The Neurodegeneration Consortium (NDC), a transformative multi-institutional initiative, will advance the study and treatment of Alzheimer's and other neurodegenerative diseases, thanks to an inaugural $25 million gift from the Robert A. and Renee E. Belfer Family Foundation to The University of Texas MD Anderson Cancer Center, Baylor College of Medicine and the Massachusetts Institute of Technology (MIT).

13 Sep 2012

Pregnancy exposures may increase risk of breast cancer in multiple generations of offspring

Chemicals or foods that raise estrogen levels during pregnancy may increase cancer risk in daughters, granddaughters, and even great-granddaughters, according to scientists from Virginia Tech and Georgetown University.

12 Sep 2012

The Institute of Cancer Research, CRT and Astex to discover and develop novel drug candidates

Astex Pharmaceuticals, Inc, a pharmaceutical company dedicated to the discovery and development of novel small molecule therapeutics, Cancer Research Technology Limited (CRT) and The Institute of Cancer Research, London, have initiated a collaboration to discover and develop drug candidates targeting an undisclosed epigenetic target in a blood cancer with high unmet medical need.

7 Sep 2012

Epigenetics News and Research

Latest Epigenetics News and Research

People with SIRT1 genetic variation more likely to develop vibration-induced white finger disease

Autism Speaks announces new round of research grants

DNp63a protein employs epigenetics to keep cancer cells alive

Researchers discover path to identify why genetic variants increase breast cancer risk

PAM50 potentially simplifies underlying breast tumor biology

Study on epigenetics link of PTSD and respiratory disease in 9/11 responders

Researchers identify gene linked to common cause of lower back pain

Genome-wide epigenomic screening can pinpoint thyroid disease-associated variants

Maternal choline intake could essentially change fetal genetic expression into adulthood

What moms eat before pregnancy affects children epigenetically

Scientists identify unique molecular signature in iPSCs that show promise in regenerative medicine

Modifying fat intake during pregnancy benefits children regardless of mother's size

ICREA researcher updates latest findings in applied epigenetics

NDC to advance study and treatment of Alzheimer's and other neurodegenerative diseases

Pregnancy exposures may increase risk of breast cancer in multiple generations of offspring

The Institute of Cancer Research, CRT and Astex to discover and develop novel drug candidates

Fusion-negative prostate tumours display more aberrant DNA methylations

Converting blood cells to a stem cell state: an interview with Elias Zambidis, M.D., Ph.D.

More than 40 plant-based compounds can turn on genes that slow the spread of cancer

Parental methylated histones not transferred to daughter DNA

eBook: A guide to RNA sequencing eBook

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Epigenetics News and Research

Latest Epigenetics News and Research

eBook: A guide to RNA sequencing eBook

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

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