Sickle Cell Anemia

Sickle cell anemia is a serious disease in which the body makes sickle-shaped red blood cells. “Sickle-shaped” means that the red blood cells are shaped like a "C." Normal red blood cells are disc-shaped and look like doughnuts without holes in the center. They move easily through your blood vessels. Red blood cells contain the protein hemoglobin. This iron-rich protein gives blood its red color and carries oxygen from the lungs to the rest of the body. Sickle cells contain abnormal hemoglobin that causes the cells to have a sickle shape. Sickle-shaped cells don’t move easily through your blood vessels. They’re stiff and sticky and tend to form clumps and get stuck in the blood vessels. (Other cells also may play a role in this clumping process.) The clumps of sickle cells block blood flow in the blood vessels that lead to the limbs and organs. Blocked blood vessels can cause pain, serious infections, and organ damage.
What is Sickle-Cell Disease?

Sickle cell disease (SCD), also known as sick cell anaemia, encompasses a group of genetic disorders characterized by abnormal haemoglobin in red blood cells.

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Latest Sickle Cell Anemia News and Research

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

Carbon monoxide foam in the fight against inflammation

Carbon monoxide foam in the fight against inflammation

Efficacy of vaccination against SARS-CoV-2 Omicron BA.1 and BA.2 sublineages in Sweden

Efficacy of vaccination against SARS-CoV-2 Omicron BA.1 and BA.2 sublineages in Sweden

Researchers develop universal AI algorithm to "clean" noisy single-cell RNA sequencing data

Researchers develop universal AI algorithm to "clean" noisy single-cell RNA sequencing data

Researchers reveal unique signature of genes expressed by hematopoietic stem cells

Researchers reveal unique signature of genes expressed by hematopoietic stem cells

Drugs that increase fetal hemoglobin levels may help people with sickle cell disease

Drugs that increase fetal hemoglobin levels may help people with sickle cell disease

New method of stem cell transplantation may eliminate the need for radiation or chemotherapy

New method of stem cell transplantation may eliminate the need for radiation or chemotherapy

Lehigh’s undergraduate students receive NIH Award for new sickle cell diagnostic device

Lehigh’s undergraduate students receive NIH Award for new sickle cell diagnostic device

Hydroxyurea therapy can improve or reverse cardiac complications in sickle cell anemia patients

Hydroxyurea therapy can improve or reverse cardiac complications in sickle cell anemia patients

UB scientists publish a detailed guide for producing mature human cells in a mouse embryo

UB scientists publish a detailed guide for producing mature human cells in a mouse embryo

Researchers develop proof-of-concept treatment for blood disorders

Researchers develop proof-of-concept treatment for blood disorders

Novel approach to gene editing bypasses disease-causing mutations in a gene

Novel approach to gene editing bypasses disease-causing mutations in a gene

Research may lead to a significant breakthrough in the battle against deadly brain tumors

Research may lead to a significant breakthrough in the battle against deadly brain tumors

'Miracle poison' can target a variety of different proteins

'Miracle poison' can target a variety of different proteins

Study: TALEN is five times more efficient than CRISPR-Cas9 in tightly packed DNA

Study: TALEN is five times more efficient than CRISPR-Cas9 in tightly packed DNA

New method could help determine the most appropriate treatment for HIV patients

New method could help determine the most appropriate treatment for HIV patients

New procedure offers lasting pain relief for patients with osteoarthritis

New procedure offers lasting pain relief for patients with osteoarthritis

Study finds more effective treatment for children with sickle cell anemia

Study finds more effective treatment for children with sickle cell anemia

Researchers treat TMC1-related deafness with gene therapy

Researchers treat TMC1-related deafness with gene therapy

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients