Sickle Cell Anemia

Sickle cell anemia is a serious disease in which the body makes sickle-shaped red blood cells. “Sickle-shaped” means that the red blood cells are shaped like a "C." Normal red blood cells are disc-shaped and look like doughnuts without holes in the center. They move easily through your blood vessels. Red blood cells contain the protein hemoglobin. This iron-rich protein gives blood its red color and carries oxygen from the lungs to the rest of the body. Sickle cells contain abnormal hemoglobin that causes the cells to have a sickle shape. Sickle-shaped cells don’t move easily through your blood vessels. They’re stiff and sticky and tend to form clumps and get stuck in the blood vessels. (Other cells also may play a role in this clumping process.) The clumps of sickle cells block blood flow in the blood vessels that lead to the limbs and organs. Blocked blood vessels can cause pain, serious infections, and organ damage.
What is Sickle-Cell Disease?

Sickle cell disease (SCD), also known as sick cell anaemia, encompasses a group of genetic disorders characterized by abnormal haemoglobin in red blood cells.

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Latest Sickle Cell Anemia News and Research

Study finds more effective treatment for children with sickle cell anemia

Study finds more effective treatment for children with sickle cell anemia

Researchers treat TMC1-related deafness with gene therapy

Researchers treat TMC1-related deafness with gene therapy

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

Study explores whether senicapoc drug can mitigate lung damage in COVID-19 patients

Gene-editing taken to advanced levels in human stem cells

Gene-editing taken to advanced levels in human stem cells

3D capillary system offers a new approach to investigate obstruction of microvessels

3D capillary system offers a new approach to investigate obstruction of microvessels

Horizon Discovery to offer novel base editing technology for clinical research

Horizon Discovery to offer novel base editing technology for clinical research

Using CRISPR to switch off pain gene becomes a possibility with new study

Using CRISPR to switch off pain gene becomes a possibility with new study

Scientists develop 3D atlas of bone marrow to help study blood diseases

Scientists develop 3D atlas of bone marrow to help study blood diseases

Prenatal screening for hemoglobinopathies different in OBGYN practices and family medicine

Prenatal screening for hemoglobinopathies different in OBGYN practices and family medicine

Adding plant-based compound to gene therapy could improve treatment outcomes

Adding plant-based compound to gene therapy could improve treatment outcomes

CDC to fund sickle cell disease surveillance

CDC to fund sickle cell disease surveillance

Researcher aims to make CRISPR-Cas9 system safer and more precise

Researcher aims to make CRISPR-Cas9 system safer and more precise

Researchers develop new way to measure how mechanical fatigue affects biological cells

Researchers develop new way to measure how mechanical fatigue affects biological cells

First ever American gene-editing treatment using CRISPR for genetic disease

First ever American gene-editing treatment using CRISPR for genetic disease

Single-cell encapsulation technology can protect transplanted MSCs from immune attack

Single-cell encapsulation technology can protect transplanted MSCs from immune attack

Three signs of real progress against sickle cell disease

Three signs of real progress against sickle cell disease

More screening and new treatments needed for sickle cell disease

More screening and new treatments needed for sickle cell disease

New gene therapy cures babies with fatal 'Bubble Boy' disease

New gene therapy cures babies with fatal 'Bubble Boy' disease

Cancer patients and those with anemia should not be denied opioids, says CDC

Cancer patients and those with anemia should not be denied opioids, says CDC

Deadly inherited blood disorders cured with bone marrow transplant

Deadly inherited blood disorders cured with bone marrow transplant