Immunosuppressive drugs are a double-edged sword to type 1 diabetics

NewsGuard 100/100 Score

Type 1 diabetes is caused when immune cells attack and destroy the insulin producing beta-cells of the pancreas.

Although insulin injections have changed the life of type I diabetics, they neither cure the disease nor prevent its severe complications.

It was hoped that islet transplantation would provide a cure, however, transplant success is short-lived and accompanied by significant side effects.

New data from Yuval Dor and colleagues at the Hebrew University-Hadassah Medical School, Jerusalem, have indicated that the immunosuppressive drugs used to prevent rejection of islet transplants suppress beta-cell regeneration in diabetic mice.

As mentioned by the authors and discussed in the accompanying commentary by Klaus Kaestner from the University of Pennsylvania, Philadelphia, this raises the possibility that if immunosuppressive drugs that do not inhibit beta-cell regeneration can be identified successful regenerative islet transplantation might become a reality.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Study unlocks genetic secrets in APOEε4 carriers that could defend against Alzheimer's