Silver nanoparticles effective at killing all kinds of bacteria

Writing in the International Journal of Nanoparticles, Rani Pattabi and colleagues at Mangalore University, explain how blasting silver nitrate solution with an electron beam can generate nanoparticles that are more effective at killing all kinds of bacteria, including gram-negative species that are not harmed by conventional antibacterial agents.

Your running shoes, socks and even computer keyboard may be impregnated with silver nanoparticles that can kill some bacteria, keep you smelling sweet and preventing the spread of infection among computer users. Researchers in India point out that silver nanoparticles are not only antibacterial against so-called gram-positive bacteria, such as resistant strains of Staphylococcus aureus and Streptococcus pneumoniae but, also against gram-negative Escherichia coli and Pseudomonas aeruginosa.

Bacterial resistance to conventional antibiotics is threatening human health the world over. Medicinal chemists are desperately trying to develop new compounds that can kill strains such as MRSA (methicillin, or multiple-resistant Staphylococcus aureus) and E. coli O157. Frontline defenses, such as environmentally benign and cost-effective antibacterial compounds could prevent such infective agents spreading through contact with computer keyboard, phones and other devices.

Silver has been known to have antibacterial properties since ancient times. A modern technological twist means it has come to the fore for a wide range of applications because of the emergence of resistance to antibacterial gels. As such a new industry involving the production of bacteriostatic agents, including silver nanoparticles, has emerged.

Researchers have been experimenting with radiation to split silver compounds, releasing silver ions that then clump together to form nanoparticles. The incentive lies in the fact that such an approach avoids the need for costly and hazardous reducing agents and can be fine-tuned to produce nanoparticles of a controlled size, which is important for controlling their properties. Pattabi and colleagues have used electron beam technology to irradiate silver nitrate solutions in a biocompatible polymer, polyvinyl alcohol, to form their silver nanoparticles.

Preliminary tests show that silver nanoparticles produced by this straightforward, non-toxic method are highly active against S. aureus, E. coli, and P. aeruginosa.