A Clemson University scientist was awarded a two-year, $147,157 grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to find a cure for an infectious disease.
Lesly Temesvari, Alumni Distinguished Professor in Clemson's biological sciences department and researcher in Clemson's Eukaryotic Pathogens Innovation Center (EPIC), works on the stress response in the human pathogen, Entamoeba histolytica. This infectious amoeba is prevalent in developing nations with substandard sanitation. It causes dysentery in as many as 50 million people annually.
"During infection in the human host, the parasite likely confronts stress brought on by the host environment and immune response," said Temesvari. "To survive and cause infection, the parasite must circumvent these external pressures. Thus, it may be useful to interrupt the pathogen's stress response for therapy."
Her research will use state-of-the-art molecular and cellular biology approaches to characterize the stress response in the parasite, which may reveal new targets for drug design.