Apr 17 2014
NeuroVive (STO:NVP), a leading mitochondrial medicine company, is presenting a breakthrough in the company's work on energy regulation at the cellular level. Based on the UK company Selcia Ltd's medical chemistry technology and NeuroVive's assays and knowledge of mitochondrial dysfunction, the parties have produced an all-new class of experimental drug which potentially could be used to treat genetic diseases and acute medical conditions that affect energy production in the mitochondria. This project has been designated NVP015 "the Amber Project" in-house. An extensive patent application on these compounds and their potential usage was published in the WIPO (World Intellectual Property Organization) database on April 10. The underlying scientific data for this breakthrough will be presented for the first time at an international research symposium in Pittsburgh on June 4 - 7.
In simplified terms, the mitochondria can be considered as the energy factory of cells. There is currently scientific data indicating that many medical conditions, from chronic diseases to acute conditions affecting the heart and brain, are linked to their function. Succinic acid is a central component in energy production. This compound is involved in many pathogenic changes to energy production, which means that adding succinic acid can restore energy production. However, succinic acid is normally unable to transit the cell wall independently. NeuroVive's and Selcia's researchers have resolved this problem by altering succinic acid in various ways, with the result that the compound is able to transit the cell wall and then be freed up and utilized in mitochondrial energy production.
Therapy areas and current development work The new drug candidates may potentially be used to prevent or treat primary or secondary mitochondrial conditions and restore normal function. This means that if current development work is successful, they may be suitable to treat a large number of rare genetic conditions, as well as more general disorders where there is an increased need for energy. This dual application extends the potential for this new class of pharmaceutical.
These new experimental drugs are currently undergoing formulation work. Their efficacy and potential adverse events must be examined in animal studies before they can be trialed on humans. The first major validation study on animals will be conducted in 2014.
New medical analysis method for mitochondrial function in human cells NeuroVive's research team has also developed a medical analysis method for energy regulation in human cells that enables the study of molecules and pharmaceuticals that can directly increase or decrease energy production. This method, called ToxPhos®, has the potential for future use to support the diagnosis of mitochondrial disease and medical conditions. The method, although not used to produce the 'Amber' compounds, was central in the screening process of the energy-regulating experimental drugs and is the foundation for the development of several preclinical models for mitochondrial conditions. The patent application for this method was also published in the WIPO patent database on 10 April.
"Research into mitochondrial medicine in recent years has demonstrated that far more diseases and medical conditions may potentially be sourced from mitochondrial defects than previously believed. That's why it was a natural move for us to start developing pharmaceuticals that not only protect the mitochondria in cell damage, but also offer the potential for cells to produce normal amounts of energy in injury and disease. These new experimental drugs that we're developing may potentially be used as emergency treatment in cellular energy crisis in children with congenital limitations to energy production and, potentially, for other conditions where raised energy production counters the course of diseases. We're really proud to be able to present the underlying scientific discoveries at this symposium in June," commented Eskil Elmér, NeuroVive's CSO.
"The new experimental drugs have the potential to address a market worth billions of kronor and a substantial medical need in the treatment of rare diseases that affect the mitochondria. This application has great potential to secure orphan drug designation, which means a fairly speedy process prior to market launch and a long period of market exclusivity. These diseases usually affect children, which makes it extra urgent to start designing a suitable formulation and begin preparation of preclinical safety testing required before experimental drugs can be administered to patients in clinical trials," continued Mikael Brönnegård, NeuroVive's CEO.
Presentation at an international symposium in June These new experimental drugs and the underlying scientific discoveries, including the new medical analysis method ToxPhos®, will be presented by NeuroVive's researchers at the United Mitochondrial Disease Foundation Symposium in Pittsburgh on June 4-7. There's more information on the conference at www.umdf.org.
Source:
NeuroVive Pharmaceutical AB