TSRI scientist receives $2.1M grant to study therapeutic potential of alternatives to current crop of anti-diabetic drugs

NewsGuard 100/100 Score

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $2.1 million from the National Institutes of Health to study the therapeutic potential of safer and more effective alternatives to the current crop of anti-diabetic drugs, which have been limited in their use due to side effects including bone loss and congestive heart failure.

Douglas Kojetin, a TSRI associate professor, is the principal investigator for the new five-year study.

The study will take a cue from the two mainstays of type 2 diabetes treatment-pioglitazone (Actos) and rosiglitazone (Avandia). Both drugs raise the body's sensitivity to insulin, increasing the amount of glucose or sugar absorbed by the cells.

Studies have shown, however, that while these and other recently developed drugs are designed to bind to a specific site on the PPAR gamma (PPARG) nuclear receptor, they can also bind to an alternative site.

"This unexpected finding opens a lot of potential opportunities," Kojetin said. "We're looking to design a molecule that blocks both sites and can be used to probe what this alternative binding does on a molecular level-with the hope that this information will help us come up with a better drug model."

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Study finds erectile dysfunction drugs linked to lower Alzheimer's risk