Neuroprotective effects of lithium are likely related to gene expressions

NewsGuard 100/100 Score

Lithium, as a neuroprotective agent, benefits for neuronal survival. Recent cDNA array studies have demonstrated that mood stabilizer lithium exhibits neuroprotective effects through multiple targets. Dr. Riadh Nciri and his team, Purpan Medicine Faculty, Paul Sabatier University, France, exposed SH-SY5Y cells to 0.5 mmol/L lithium carbonate for 25-50 weeks and then detected the expression levels of some neurobiology related genes and post-translational modifications of stress proteins in SH-SY5Y cells.

cDNA arrays showed that pyruvate kinase 2 (PKM2) and calmodulin 3 expression levels were significantly down-regulated, phosphatase protein PP2A expression was lightly down-regulated, and casein kinase II, threonine/tyrosine phosphatase 7, and dopamine beta-hydroxylase expression levels were significantly up-regulated. Besides, western blot analysis of stress proteins (HSP27, HSP70, GRP78 and GRP94) showed an over-expression of two proteins: a 105 kDa protein which is a hyper-phosphorylated isoform of GRP94, and a 108 kDa protein which is a phosphorylated tetramer of HSP27. These results suggest that the neuroprotective effects of lithium are likely related to gene expressions and post-translational modification of proteins cited above. This paper was published in Neural Regeneration Research (Vol. 9, No. 7, 2014).

Source: Neural Regeneration Research

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
New research pinpoints key pathways in prostate cancer's vulnerability to ferroptosis