A large simulation study suggests that increasing milk intake to recommended levels could lower stroke incidence and reduce national healthcare spending in Japan, highlighting how small dietary changes may deliver meaningful public health gains.

Study: Projected Health and Economic Impacts of Achieving the Recommended Dairy Intake in Japan: A Simulation Study of Increased Milk Consumption for Stroke Prevention. Image Credit: Tarasyuk Igor / Shutterstock
A recent study in the journal Nutrients suggests that increasing milk consumption to meet recommended milk intake levels consistent with national dairy guidelines could be projected to reduce both stroke incidence and healthcare costs in Japan.
Researchers modeled the impact of raising average milk intake to recommended levels of 180 grams per day, equivalent to two daily dairy servings, among adults aged 30 to 79 years. Across a 10-year period, this change was estimated to decrease stroke incidence and stroke-related mortality by about 7.0% overall (with subgroup reductions reaching up to 10.6%) and reduce stroke-related national healthcare expenditure (NHE) by about 5.1% overall (with subgroup reductions up to 8.5%), highlighting the population-level potential benefits of modest dietary shifts.
Stroke burden and dairy intake gaps in Japan
Stroke continues to be a significant health concern across Japan and ranks among the country’s leading causes of death. The condition places considerable pressure on healthcare services. It often leaves survivors with long-term limitations in daily functioning and quality of life. Researchers increasingly recognize diet as a modifiable contributor to reducing stroke risk. Recent meta-analyses suggest that higher milk intake correlates with a lower likelihood of stroke. Milk supplies minerals such as calcium, magnesium, and potassium that have been proposed as potential contributors to cardiovascular protection, although the precise biological mechanisms remain uncertain.
Nevertheless, dairy intake in Japan falls short of the intake targets outlined in the national dietary guide. Consequently, the population-level benefits and healthcare savings associated with meeting these recommendations through increased milk consumption specifically remain uncertain.
Markov model simulates dietary intervention scenarios
In this study, researchers applied an age- and sex-stratified Markov model to simulate the health effects and cost implications of increasing milk consumption in Japan. The model projected the incidence of stroke, associated mortality, and stroke-related NHE among adults over a decade. Each cycle in the simulation represented one year.
Stroke outcomes included intracerebral hemorrhage, subarachnoid hemorrhage, and cerebral infarction. The simulated population comprised individuals without a prior stroke, stroke survivors, those who died from stroke, and those who died from unrelated causes. Stroke-related spending covered inpatient treatment, ambulatory services, and medication costs.
The researchers modeled two intervention scenarios: an immediate shift to the recommended milk intake level and a steady yearly increase until the target was reached. Both were compared with a baseline scenario that maintained average milk intake levels observed in 2023.
Key inputs included sex-specific 28-day stroke fatality rates of 14.9% for men and 15.7% for women, recurrence rates of 28.2% and 24.8%, and a relative stroke risk of 0.82 per 200 g of milk intake in Asian populations. The team converted healthcare costs denominated in Japanese yen to US dollars using exchange rates from the International Monetary Fund (IMF). They applied a 2.0% annual discount rate consistent with Japanese guidelines for health economic assessment.
Lastly, the researchers conducted sensitivity analyses to assess the robustness of the projections. They adjusted stroke-related model inputs using their 95% confidence intervals. They also varied the assumed discount rate from 0% to 4% to evaluate uncertainty in the model projections.
Simulations project reductions in stroke incidence and healthcare costs
The simulations indicated that increasing milk consumption in the model could reduce stroke burden and related healthcare costs in Japan. In comparison with the baseline scenario, an immediate increase in milk intake to 180 grams per day was estimated to lower stroke incidence and stroke-associated mortality by 7.0%. A gradual annual increase in intake produced smaller but still measurable benefits, reducing these outcomes by 3.2%. The model also predicted reductions in stroke-associated NHE. In the immediate intervention scenario, stroke-related spending declined by 5.1%, while the gradual increase scenario produced a 2.2% decrease.
In both simulated scenarios, the number of prevented cases and related deaths was consistently higher among males than females. The greatest absolute declines occurred in adults aged 70–79 years. However, the greatest percentage reductions were observed in younger groups, particularly men aged 40–49 years and women aged 30–39 years. These patterns may reflect relatively low initial dairy intake among younger adults, suggesting that greater milk intake produced larger proportional benefits.
Sensitivity analyses indicated that the estimated effect of milk intake on stroke risk was the main driver of uncertainty in the projections. Sensitivity analyses estimated uncertainty ranges of cumulative healthcare savings reaching about USD 2.3 billion in the immediate intervention scenario and about USD 1.0 billion in the gradual increase scenario.
Population-level dietary shifts may influence stroke prevention
The findings suggest increasing milk consumption to meet recommended intake levels could potentially help reduce stroke burden in Japan. By preventing stroke incidence and related mortality, higher milk intake may also lower NHE, highlighting its potential as a promising public health strategy, although the study did not estimate the costs required to implement increased milk consumption and therefore did not conduct a full cost-effectiveness analysis.
Achieving this shift may require coordinated action from policymakers, public health agencies, and food manufacturers, including nutrition education, targeted subsidies, and improvements in the food environment.
Future studies could incorporate long-term caregiving costs to better estimate the economic impact of stroke prevention. They could also examine differences between milk types, stroke subtypes, hormonal or menopausal status, and other population characteristics to generate more precise estimates for nutrition and health policy.
Journal reference:
- Wakayama, R., Araki, M., Nakamura, M., & Ikeda, N. (2026). Projected Health and Economic Impacts of Achieving the Recommended Dairy Intake in Japan: A Simulation Study of Increased Milk Consumption for Stroke Prevention. Nutrients, 18(6). DOI: 10.3390/nu18060906, https://www.mdpi.com/2072-6643/18/6/906