A device that measures movement and balance can effectively help assess and track the progression of Parkinson's disease, even when medications are used to reduce Parkinson's symptoms, UT Southwestern Medical Center research found.
Researchers found that the APDM Mobility Lab - a portable set of sensors that track gait, balance and other movement - can effectively help clinicians estimate the depth and severity of the neurological disorder in affected individuals, even while patients are taking medications to control trembling and other symptoms. The findings appear in the Journal of the Neurological Sciences.
"Objective assessment tools for Parkinson's disease are needed to accelerate progress in developing effective therapies," said
The APDM Mobility Lab uses wearable sensors and sophisticated signal processing to track even subtle changes in gait, stride, balance, rotation, and efficiency and range of movement in upper and lower limbs and torsos. The system is typically used for athletic training and by universities for research and evaluation.
The UT Southwestern findings evolved from a clinical trial comparing 135 individuals with Parkinson's disease and 66 people without the disorder. Participants performed two tasks designed to assess gait and balance while connected to the APDM Mobility Lab through six small sensors on the limbs, chest, and lumbar area. The study was supported by the National Institutes of Neurological Disorders and Stroke Parkinson Disease Biomarker Program.
Dr. Thomas McConnell, who has early-stage Parkinson's disease, was a participant in the clinical trial.
"I understand the necessity of good research to advance medical care and treatment," said Dr. McConnell, a Clinical Professor of Pathology at UT Southwestern. "This is a diagnostic trial, not therapeutic. But now we have hope for an earlier and more certain diagnosis of Parkinson's disease, and identifying the most effective treatment."
UT Southwestern Medical Center