Study reveals long-term behavioral deficits after developmental Zika infection

Mice exposed to the Zika virus during later stages of gestation present behaviors reminiscent of attention-deficit/hyperactivity disorder, according to a study of genetically diverse animals. The findings, published in JNeurosci, suggest children exposed to the virus during the 2015-16 epidemic may harbor increased risk for developmental disorders.

Study reveals long-term behavioral deficits after developmental Zika infection
Widespread calcifications may underlie the behavioral deficits observed. Credit: Snyder-Keller et al., JNeurosci (2019)

Microcephaly — a smaller than normal head — is the most well-known and visible consequence of Zika virus exposure. Recent research, however, has found brain and behavior abnormalities in Zika-exposed infants without microcephaly.

Abigail Snyder-Keller and colleagues at the New York State Department of Health and the University of Albany School of Public Health examined these more subtle disruptions in male and female mice of four distinct genetic backgrounds. The public health researchers exposed mice to the virus during a period analogous to the third trimester in humans and report different effects depending on the sex and strain of the mouse. This research provides a first step toward studying the full range of possible outcomes in individuals exposed to the Zika virus in the womb

Source:

Society for Neuroscience

Journal reference:

Snyder-Keller, A. et al. (2019) Mouse strain and sex-dependent differences in long-term behavioral abnormalities and neuropathologies after developmental zika infection. JNeurosci. doi.org/10.1523/JNEUROSCI.2666-18.2019

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Society for Neuroscience. (2019, May 14). Study reveals long-term behavioral deficits after developmental Zika infection. News-Medical. Retrieved on October 20, 2019 from https://www.news-medical.net/news/20190514/Study-reveals-long-term-behavioral-deficits-after-developmental-Zika-infection.aspx.

  • MLA

    Society for Neuroscience. "Study reveals long-term behavioral deficits after developmental Zika infection". News-Medical. 20 October 2019. <https://www.news-medical.net/news/20190514/Study-reveals-long-term-behavioral-deficits-after-developmental-Zika-infection.aspx>.

  • Chicago

    Society for Neuroscience. "Study reveals long-term behavioral deficits after developmental Zika infection". News-Medical. https://www.news-medical.net/news/20190514/Study-reveals-long-term-behavioral-deficits-after-developmental-Zika-infection.aspx. (accessed October 20, 2019).

  • Harvard

    Society for Neuroscience. 2019. Study reveals long-term behavioral deficits after developmental Zika infection. News-Medical, viewed 20 October 2019, https://www.news-medical.net/news/20190514/Study-reveals-long-term-behavioral-deficits-after-developmental-Zika-infection.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
Social isolation in adolescence disrupts brain development, mice study shows