Smoking in early puberty in boys may affect the health of future generations, study shows

Smoking in early puberty in boys may have negative consequences for their future generations of offspring, a study from the University of Bergen (UiB) shows.

By continued analysis of data gathered in the large international RHINESSA, RHINE and ECRHS studies, researchers have found that the health of future generations depends on actions and decisions made by young people today. This is particularly relevant for boys in early puberty and mothers/grandmothers both pre-pregnancy and during pregnancy, the study shows.

The paper "Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modeling approach" was recently published in the European Respiratory Journal. The study highlights the importance of putting greater focus on smoking in young people (defined as before 15 years of age) to prevent potential damage on lung function in future generations. It also suggests including the use of moist oral tobacco (snus) and e-cigarette use.

According to the World Health Organization (WHO), roughly 6 million people die from tobacco-related ailments every day. The number is projected to rise over 8 million by 2030. The UiB-study underlines that the smokers not only jeopardize their own health, but also the health of their children and possibly their grandchildren.

Changes in the male germ cells

The study finds that both the pre-natal period and the pre-puberty period are times of high importance for the growing of cells, in particular germ cells. The researchers suggest that lifestyle and environmental factors impact respiratory health by epigenetic changes transmitted through male germ cells. Further, the study finds that lifestyle-related exposures during these periods influence the health of future generations.

In addition to reduced lung-function, the RHINESSA study finds that prepubertal smoking in boys can lead to obesity in their sons. However, interventions that aim to prevent smoking (nicotine use) in the most vulnerable time-windows, might have potential benefits for several generations.

Source:
Journal reference:

Accordini, S., et al. (2021) Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach. European Respiratory Journal. doi.org/10.1183/13993003.02791-2020.

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