Research could help develop better treatments for swallowing disorders

NewsGuard 100/100 Score

Sensory cells in the vagus nerve can detect and locate food in the esophagus. Their signals help transport the food onward to the stomach. Signal failure leads to swallowing disorders, say a team led by Carmen Birchmeier at the Max Delbrück Center. They have published their findings in "Neuron."

Swallowing disorders can have many causes, and they occur more frequently in older people. But neurological diseases such as multiple sclerosis and Parkinson's disease, and certain medications, can also prevent food moving normally from mouth to stomach. Possible consequences include malnutrition, weight loss, and dehydration.

Now a team led by Professor Carmen Birchmeier, who runs the Developmental Biology/Signal Transduction Lab at the Max Delbrück Center in Berlin, has investigated the process of swallowing in more detail. Writing in the journal "Neuron", the researchers describe how sensory cells of the vagus nerve react to mechanical stimuli in the esophagus and trigger involuntary muscles movement, a process known as esophageal peristalsis. The vagus nerve, one of the 12 cranial nerves, provides information about the status of inner organs to the brain. The team's study results could eventually lead to better treatments for swallowing disorders.

Swallowing on camera

Modern methods of single-cell sequencing made our work possible. Using the sequencing data, we constructed genetic models that allowed us to study the functions of the sensory neurons in the vagal ganglia in more detail."

Professor Carmen Birchmeier, Developmental Biology/Signal Transduction Lab, Max Delbrück Center, Berlin

Ganglia are a group or "node" of neuronal bodies in the peripheral nervous system.

The scientists began by staining the neurons to see which organs they innervate. Then they determined whether and how they responded to mechanical stimuli in the esophagus. Lastly, they deactivated the cells to analyze how this affected swallowing. Dr. Teresa Lever of the University of Missouri School of Medicine in Columbia, USA, developed a method that allowed the researchers to use video fluoroscopy to observe the swallowing in freely behaving, non-anesthetized mice in real time.

More than just a tube

"When mice lost the neurons that provide information about mechanical stimuli in the esophagus, they lost the ability to reflexively perform the appropriate muscle movements that transport food to the stomach, and they quickly lost weight," says lead author Dr. Elijah Lowenstein, who earned his PhD working on this study in Birchmeier's team. He's now a researcher at Harvard Medical School in Boston. The weight loss, says Lowenstein, shows that the neurons play a key role in bodily homeostasis.

"So, the esophagus isn't just a tube that connects the mouth to the stomach," he says. "It uses mechanosensory feedback to fulfill its function." Birchmeier adds that without these cells in the vagus nerve, food gets stuck in our esophagus. In some of the mice, it actually flowed back into the throat.

A molecular atlas for all

"Our work can now help develop better treatments for swallowing disorders. One option would be to pharmacologically activate the mechanoreceptors we identified," says Birchmeier. She also wants to use the genetic models to determine the functions of other vagal sensory neurons – such as those that control the lungs or aorta.

"These neurons probably play a crucial but as-yet unknown role in the development of certain respiratory diseases, or cardiovascular diseases such as hypertension," she says. Other researchers can also participate in these projects, as Birchmeier and her team have developed a molecular atlas for all vagal neurons in mice. The atlas is freely available online.

Source:
Journal reference:

Lowenstein, E. D., et al. (2023) Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. Neuron. doi.org/10.1016/j.neuron.2023.04.025.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Genetic variant increases heart failure risk and decreases longevity in Black Americans