Mycotoxin contamination is still a serious food/feed safety issue

In a recent article published in the Toxins Journal, researchers presented the updated and most recent evidence of the occurrence and co-occurrence of mycotoxins in cereal grains, one of the food staples for humans, livestock feed, and pet food, and their adverse health effects.

In addition, the study described prevention and detoxification methods to keep food and livestock feed safe from mycotoxins.

Furthermore, the study discussed regulation limits for mycotoxins in major cereal-producing countries and proposed some areas worthy of further research.

Study: Mycotoxins in Cereal-Based Products and Their Impacts on the Health of Humans, Livestock Animals and Pets. Image Credit: TomaszKlejdysz/


Mycotoxins, secondary metabolites of toxic fungi/molds, are synthesized mainly by Aspergillus, Fusarium, Penicillium, and Alternaria generaCereals could be contaminated by fungi in the field and post-harvesting, particularly during storage, especially in hot and humid climates.

Some common mycotoxins in cereals are aflatoxins (AFs), ochratoxins (OTs), and Fumonisins (FUMs). The genus Fusarium also produces Zearalenone (ZEA) and trichothecenes. 

Besides cereals, mycotoxins contaminate other agricultural commodities, e.g., spices, nuts, coffee beans. Studies have implicated mycotoxin contamination in acute toxicity and chronic diseases in humans, e.g., cancer and neural tube defects. 

Developing countries face food shortages and less strict implementation of food safety regulations. For instance, in African and Asian countries where people depend on corn, the risk of mycotoxicoses is high.

Moreover, these countries have barely been able to develop and implement cost-effective detoxification methods to reduce the toxicity of contaminated grains.

In developed countries, food supply is ample, and food safety regulations are also adequate. Thus, mycotoxin contamination of cereal grains is not a safety issue for their adult populations.

However, the risk of mycotoxin contamination persists for infants, young children, livestock, and pets.

Mycotoxins in cereals and their adverse health effects

Studies suggest that the prevalence of mycotoxins in unprocessed cereals ranges from 60-80%.

The 2020 BIOMIN World Mycotoxin Survey Report showed that Fusarium mycotoxins, deoxynivalenol (DON) and Fumonisins (FUM) were the most prevalent globally, followed by Zearalenone (ZEA).

Notably, food processing can lower mycotoxin levels in cereal-based foods but not wholly eliminate it.

In humans, AF-caused acute mycotoxin poisoning has led to several outbreaks in different countries, resulting in fatalities.

For instance, mycotoxin outbreaks in Taiwan and Malaysia (1967 and 1988) claimed the lives of people who consumed contaminated moldy rice and Chinese noodles, respectively.

The severity of their effects depends on age, gender, and the type and quantity of food consumed. Chronic exposure to AFs and FUMs can cause cancer, liver diseases, neural tube defects in neonates, and impaired fetal growth.

Researchers have used animal studies to show the effects of varying oral lethal doses of OTs in different species, with dogs and pigs showing more sensitivity than mice. Likewise, in vitro studies helped the researchers understand the pathogenic mechanisms underpinning mycotoxin toxicity.

Animal feed, particularly cereals and oilseed by-products, and complete feeds and their ingredients are co-contaminated with multiple mycotoxins. Mycotoxin contamination in poultry feed also exceeds safety standards in various countries.

Mycotoxins adversely affect animal health even when consumed at doses slightly above the regulation limits. Ingesting highly contaminated feed caused acute intoxication in livestock in Western India in 1974.

Aflatoxin and OTA caused kidney diseases in livestock in Europe and Egypt and esophageal cancer caused by FUMs in Africa and some regions of China.


Mycotoxin contamination of cereals and cereal-based products is a serious food and feed safety issue, particularly in developing countries. It necessitates the implementation of pre-and post-harvest mycotoxin control strategies to reduce the degree of contamination.

Pre-harvest strategies include breeding resistant seeds using biological seed treatments and implementing good agricultural practices.

Some post-harvest strategies for mycotoxin control are adequately drying whole grain cereals to a safe moisture level, using food storage facilities with appropriate aeration systems, and utilizing antifungal packaging.

Detoxification of mycotoxin-contaminated cereal grains requires sorting, processing, and using mycotoxin binders. Biocontrol of mycotoxins via bioactive metabolites has shown promise, but it is costly and adversely affects the texture and flavor of cereals.

Studies should investigate the combined effect of co-exposure to multiple mycotoxins in humans and animals. Future studies should also explore the adverse health effects of mycotoxin-contaminated dry pet food on pets.

So far, all reported data in this regard comes from the investigations after outbreaks caused by the intake of highly contaminated pet food. 

Journal reference:
Neha Mathur

Written by

Neha Mathur

Neha is a digital marketing professional based in Gurugram, India. She has a Master’s degree from the University of Rajasthan with a specialization in Biotechnology in 2008. She has experience in pre-clinical research as part of her research project in The Department of Toxicology at the prestigious Central Drug Research Institute (CDRI), Lucknow, India. She also holds a certification in C++ programming.


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  1. Sultan Ansari Sultan Ansari India says:

    The presence of mycotoxin in food and feed poses a significant safety concern. Specific molds produce these harmful substances and can infect a range of agricultural products, including nuts, grains, and animal feed. Mycotoxins can cause acute and chronic illnesses, potentially causing liver and kidney damage, immune system suppression, and even cancer, which puts both humans and animals at risk. Along with health concerns, mycotoxin contamination can lead to substantial financial losses because of rejected crops and products, along with increased healthcare expenses. Climate change and globalization further complicate the matter, as they can create conditions conducive to mycotoxin production and spread. To ensure food and feed safety, implementing effective prevention and mitigation strategies, such as proper storage, monitoring, and regulatory measures, is crucial. Equinox Labs provides food testing and other services with a PAN-India presence and 6 labs, including a NABL-approved lab.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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