Smoking identified as key factor in accelerated cognitive decline

Smoking may be among the most important lifestyle factors affecting how quickly our cognitive skills decline as we age, suggests a new study led by UCL researchers.

The study, published in Nature Communications, analyzed data from 32,000 adults aged 50 or over from 14 European countries who responded to surveys over 10 years.

The researchers investigated how rates of cognitive decline might differ among cognitively-healthy older adults with different combinations of health-related behaviors, including smoking, physical activity, alcohol consumption and social contact.

Cognitive function was assessed according to participants' performance in memory and verbal fluency tests. Participants were grouped into lifestyles based on whether they smoked or not, whether they did both moderate and vigorous physical activity at least once per week, whether they saw friends and family at least weekly, and whether they drank more or the same/less than two alcoholic drinks per day (men) or one drink per day (women).

They found that cognitive decline was faster for lifestyles that included smoking, while cognitive decline was generally similar for all non-smoking lifestyles. Smoking lifestyles had cognitive scores that declined up to 85% more over 10 years than non-smoking lifestyles.

The exception was smokers who had a healthy lifestyle in all other areas – that is, they did regular exercise, drank alcohol in moderation, and socialized regularly. This group had a rate of cognitive decline similar to non-smokers.

Our study is observational so cannot definitively establish cause and effect, but it suggests smoking might be a particularly important factor influencing the rate of cognitive aging.

Previous evidence suggests individuals who engage in more healthy behaviors have slower cognitive decline; however, it was unclear whether all behaviors contributed equally to cognitive decline, or if there were specific behaviors driving these results.

Our findings suggest that among the healthy behaviors we examined, not smoking may be among the most important in terms of maintaining cognitive function.

For people who aren't able to stop smoking, our results suggest that engaging in other healthy behaviors such as regular exercise, moderate alcohol consumption and being socially active may help offset adverse cognitive effects associated with smoking."

Dr. Mikaela Bloomberg, Lead Author, UCL Behavioural Science & Health

The researchers accounted for a range of factors that might have influenced the findings, including age, gender, country, education, wealth, and chronic conditions.

The team used data from the English Longitudinal Study of Ageing (ELSA) and the Survey of Health, Ageing and Retirement in Europe (SHARE). ELSA is funded by the National Institute on Aging and by UK Government departments coordinated by the National Institute for Health and Care Research (NIHR). SHARE receives funding from the European Union. Study authors received funding from the Economic and Social Research Council.

Source:
Journal reference:

Bloomberg, M., et al. (2024). Healthy lifestyle and cognitive decline in middle-aged and older adults residing in 14 European countries. Nature Communications. doi.org/10.1038/s41467-024-49262-5.

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