Metabolites News and Research

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Polyamines reshape protein phosphorylation to guide key cellular fate decisions

Polyamines are small molecules naturally present in all cells and are critical in guiding cellular decisions, whereas an alteration in the abundance of these metabolites is invariably observed in pathological scenarios such as cancer or aging.

14 Jan 2026

DTU researchers discover gut bacteria link to reduced allergy and asthma risk

Researchers from DTU have patented an invention that uses naturally produced substances from gut bacteria of the bifidobacteria type to reduce the risk of allergies and asthma.

14 Jan 2026

New metabolomic signature predicts type 2 diabetes risk beyond traditional factors

Diabetes, a metabolic disease, is on the rise worldwide, and over 90 percent of cases are type 2 diabetes, where the body does not effectively respond to insulin.

14 Jan 2026

Metabolic BMI reveals hidden health risks in normal weight individuals

People of normal weight may also be at risk of diabetes and similar diseases. A study from the University of Gothenburg reveals that those with an unexpectedly high so-called metabolic BMI have up to a five times higher risk level.

12 Jan 2026

Study reveals innate immune barriers to long-term pig kidney transplant survival

Pioneering research led by Brazilians describes the immune system's reactions in detail in the first living patient to receive a genetically modified pig kidney transplant.

8 Jan 2026

Natural daylight during office hours improves glucose stability in type 2 diabetes

Natural daylight exposure during office hours improves glucose control and boosts fat oxidation in individuals with type 2 diabetes, enhancing metabolic health.

8 Jan 2026

Why promising microbiome therapies rarely work in patients

Addressing the microbiome's translational gap involves understanding biological complexity and developing function-driven, patient-specific interventions.

8 Jan 2026

Breast milk bacteria help shape infant gut microbiome development

Most conversations about breast milk tend to focus on topics like nutrients, antibodies and bonding time rather than bacteria.

7 Jan 2026

Study shows beneficial impact of natural light on people with type 2 diabetes

Metabolic diseases have reached epidemic proportions in our society, driven by a sedentary lifestyle coupled with circadian misalignment - a desynchrony between our intrinsic biological clocks and environmental signals.

7 Jan 2026

The gut is not just digestive and new evidence shows it actively controls brain function

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate through hormonal, neural, immune, and microbial pathways. It highlights how disruptions in these pathways contribute to gastrointestinal, metabolic, and neurological disorders, and how modern therapies are beginning to exploit gut–brain signaling for clinical benefit.

6 Jan 2026

Streptococcus anginosus metabolites fuel gastric cancer

A recent study published in the medical journal Gut has revealed a novel cancer-promoting mechanism of Streptococcus anginosus (Sa).

6 Jan 2026

New evidence reveals Streptococcus anginosus promotes gastric cancer development

This study identifies a cancer-promoting mechanism of Streptococcus anginosus, linking microbial metabolism to gastric cancer and enhancing prevention efforts.

From BGI Genomics 6 Jan 2026

Repurposed drug combination shows strong promise against liver fibrosis

The study shows that this drug pair works far better together than either agent alone, offering a realistic and potentially fast path toward a new antifibrotic therapy.

6 Jan 2026

Vitamin A derivative suppresses immune response and cancer vaccine efficacy

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

5 Jan 2026

Prebiotic microcapsules deliver pterostilbene to the colon to alleviate ulcerative colitis

A team led by clinicians and engineers has wrapped the plant-derived polyphenol pterostilbene (PSB) into prebiotic alginate/resistant-starch microcapsules coated with chitosan and shown that oral administration dampens dextran-sulfate-sodium (DSS) colitis in mice.

23 Dec 2025

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

This study shows that a blood-based metabolomic signature linked to maternal BMI predicts gestational diabetes and preeclampsia more strongly than BMI alone, particularly in late pregnancy. A subset of 16 metabolites statistically mediates the BMI–gestational diabetes association, highlighting metabolic pathways that may improve prenatal risk stratification.

21 Dec 2025

New grant supports research into drug-induced brain toxicity

Important FDA-approved drugs to treat HIV and cancer can save lives, but they come with their own risks. Some drugs used clinically are known to cause neurological side effects in up to half of patients, ranging from confusion and memory problems to permanent nerve damage.

19 Dec 2025

Estrogen drives gut pain and explains higher rates of IBS in women

Women are dramatically more likely than men to suffer from irritable bowel syndrome (IBS), a chronic condition causing abdominal pain, bloating, and digestive discomfort.

18 Dec 2025

Research reveals how the gut microbiome supports successful pregnancy

Gut microbes may play a key role in training a mother's immune system to adapt to the developing fetus during pregnancy, according to a preclinical study by Weill Cornell Medicine investigators.

17 Dec 2025

Plant-based omega-3s work better than expected in a year-long diet study

A year-long, diet-controlled intervention shows that flaxseed oil–derived alpha-linolenic acid significantly increases erythrocyte EPA, DPA, and DHA across omnivorous, vegetarian, and vegan diets. The magnitude of improvement is driven mainly by baseline omega-3 status, while absolute EPA and DHA levels in vegans remain lower than in omnivores.

17 Dec 2025

Metabolites News and Research

Polyamines reshape protein phosphorylation to guide key cellular fate decisions

DTU researchers discover gut bacteria link to reduced allergy and asthma risk

New metabolomic signature predicts type 2 diabetes risk beyond traditional factors

Metabolic BMI reveals hidden health risks in normal weight individuals

Study reveals innate immune barriers to long-term pig kidney transplant survival

Natural daylight during office hours improves glucose stability in type 2 diabetes

Why promising microbiome therapies rarely work in patients

Breast milk bacteria help shape infant gut microbiome development

Study shows beneficial impact of natural light on people with type 2 diabetes

The gut is not just digestive and new evidence shows it actively controls brain function

Streptococcus anginosus metabolites fuel gastric cancer

New evidence reveals Streptococcus anginosus promotes gastric cancer development

Repurposed drug combination shows strong promise against liver fibrosis

Vitamin A derivative suppresses immune response and cancer vaccine efficacy

Prebiotic microcapsules deliver pterostilbene to the colon to alleviate ulcerative colitis

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

New grant supports research into drug-induced brain toxicity

Estrogen drives gut pain and explains higher rates of IBS in women

Research reveals how the gut microbiome supports successful pregnancy

Plant-based omega-3s work better than expected in a year-long diet study

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