Nitric Oxide News and Research

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Western diet weakens the gut’s nervous system through iron-dependent damage

A JCI study found that exposure to a Western diet in mice and to palmitic acid in murine and ex vivo human enteric nervous system models triggered ferroptosis, characterized by iron loading, lipid peroxidation, mitochondrial stress, and enteric neuronal loss. Boosting Nrf2 signaling protected enteric neurons and prevented Western diet-induced delayed colonic transit in mice, pointing to a potential pathway linking dietary fat exposure to gut motility dysfunction.

10 Jun 2026

Justicia carnea extract alleviates oxidative stress in pancreatitis

Chronic pancreatitis is an inflammatory disease and is difficult to manage despite advancements in medical science.

1 Jun 2026

New study reveals nitric oxide’s widespread impact on genetics

Genes undergo extensive editing through a process called alternative splicing, which greatly increases the size of the functional genome, the working portion of our DNA that helps make each person unique. Put simply, a single gene can be edited in different ways to produce multiple sets of instructions.

22 May 2026

Vitamin B12 analog targets deadly brain cancer cells

A new research paper was published in Volume 13 of Oncoscience on April 2, 2026, titled "Selective blood–brain barrier penetration and tumor targeting of nitrosylcobalamin in glioblastoma: Pharmacokinetics, tissue distribution, and synergistic activity with trail and temozolomide."

21 May 2026

Bedfont® Scientific targets international growth at EAACI Congress 2026

Bedfont® Scientific Ltd., an innovative leader in the medical breath analysis industry with almost 50 years of experience, is pleased to join thousands of healthcare experts at this year’s European Academy of Allergy and Clinical Immunology (EAACI) Congress 2026 at stand I03 to showcase its NObreath® and Gastrolyzer® range of non-invasive breath analysis devices.

From NObreath 20 May 2026

Shaping the future of asthma management with the NObreath® at ATS 2026

World leaders in breath analysis Bedfont® Scientific Ltd. are pleased to be attending this years American Thoracic Society (ATS) International Conference, to exhibit the innovative NObreath® Fractional exhaled Nitric Oxide (FeNO) device at booth 1236 alongside its US distributor coVita™.

From Bedfont® Scientific Ltd 11 May 2026

High-intensity interval exercise is most effective for heart patients

Endothelial dysfunction is a hallmark of cardiovascular disease (CVD) and plays a central role in vascular inflammation, thrombosis, and impaired vasodilation.

4 May 2026

Scientists identify STING switch driving inflammation in Alzheimer’s disease

The brain has its own immune system, which detects threats and mounts a defense. A growing body of evidence has shown that in Alzheimer's disease, those immune cells are chronically overactivated, causing inflammation that damages the connections between brain cells.

24 Apr 2026

Scientists identify new inflammatory mechanism to treat chronic health conditions

A protein long understood to drive inflammation by producing nitric oxide has a second, previously unknown role - it physically binds to another key protein inside cells to directly modulate the immune response.

24 Apr 2026

Hyperbaric oxygen therapy shows dual effects in glioblastoma treatment

Glioblastoma remains a highly challenging malignancy with a pronounced tendency for recurrence. The hypoxic microenvironment is a key contributor to its therapy resistance.

23 Apr 2026

Beetroot supplement raises nitric oxide markers in triathletes after one week

A randomized cross-over pilot study in 10 amateur male triathletes found that a beetroot-based multi-ingredient nitrate supplement increased nitric oxide-related and redox biomarkers over 7 days without evidence of lipid oxidative damage. The supplement was generally well tolerated, but the study did not measure whether these biochemical changes improved performance or recovery.

13 Apr 2026

Blocking nitric oxide suppresses tumor growth in aggressive pediatric neuroblastoma

The tumor begins before birth. Somewhere in the developing fetus, neural crest cells that should have matured into adrenal tissue or sympathetic ganglia take a wrong turn, and a child is born harboring a malignancy that may not declare itself for months.

7 Apr 2026

Prickly pear may pack a surprising punch against metabolic syndrome

This narrative review examines how Opuntia ficus-indica fruit, or prickly pear, may help target multiple features of metabolic syndrome through its fiber, betalains, polyphenols, carotenoids, and other bioactive compounds. The authors conclude that the fruit shows promising mechanistic and preclinical potential, but stronger human trials are still needed before firm clinical claims can be made.

6 Apr 2026

Experts establish standardized protocols for pediatric recurrent wheezing diagnosis

Recurrent wheezing, a respiratory disorder, is caused by the narrowing of the airways, mainly affecting children aged less than 5 years.

26 Mar 2026

Study links gut microbiome imbalance to worsening kidney disease

Researchers at UC Davis School of Medicine have uncovered how an imbalanced gut microbiome escalates the production of metabolic byproducts by certain gut bacteria.

19 Mar 2026

Study on inhaler overuse highlights urgent need for better objective asthma monitoring

Bedfont® Scientific Limited, an innovative med-tech company specializing in medical breath analysis devices, welcomes the new study at University Hospital Southampton exploring whether enhanced asthma check-ups can reduce inhaler use among children.

From NObreath 11 Mar 2026

Novel microneedle patch accelerates healing of chronic diabetic wounds using light

Researchers from Nanjing Drum Tower Hospital, Southeast University, and Wenzhou Medical University have developed a novel microneedle patch that combines MXene hydrogel with nitric oxide (NO) and hypoxia-inducible factor-1α (HIF-1α) plasmid for enhanced diabetic wound treatment.

10 Mar 2026

ATG14 found to be a critical defender against hepatic injury and fibrosis

Autophagy is indispensable for maintaining hepatocyte integrity, metabolic homeostasis, and survival. While several autophagy-related proteins have been studied in hepatic physiology, the specific role of Autophagy Related 14 (ATG14) in liver health has remained unclear.

24 Feb 2026

Do cocoa flavanols influence heart and fatty liver risk factors?

A recent Nutrients review examined whether cocoa-rich dark chocolate influences cardiovascular and metabolic dysfunction-associated steatotic liver disease risk factors through antioxidant, anti-inflammatory, and endothelial effects. Evidence suggests modest improvements in biomarkers, but most data come from short-term studies, so definitive clinical benefits remain unproven.

16 Feb 2026

Can hot baths lower high blood pressure?

A review highlights hot water immersion's potential in lowering blood pressure, emphasizing it as an adjunct therapy alongside traditional treatments.

12 Feb 2026