Efficacy News and Research

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GLP-1 weight-loss drugs show early promise for treating addiction

This systematic review evaluates preclinical and clinical evidence on glucagon-like peptide-1 receptor agonists as potential treatments for substance use disorders. Findings show consistent reductions in drug- and alcohol-seeking behaviors in animal models, while human evidence remains limited, heterogeneous, and preliminary.

21 Jan 2026

Study finds no safety or efficacy gap between paracetamol and ibuprofen for neonatal PDA

In a UK pilot randomized trial, intravenous paracetamol and ibuprofen showed no statistically significant differences in short-term efficacy or safety when used as rescue therapy for hemodynamically significant patent ductus arteriosus in very preterm infants. The study demonstrated high feasibility but was not powered to determine clinical superiority or equivalence between treatments.

21 Jan 2026

NuSHs can be a promising therapeutic strategy for preventing MASH-related hepatocellular carcinoma

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), represent the most common chronic liver diseases in Western populations, driven largely by obesity and insulin resistance.

21 Jan 2026

Mitotane’s role in the management of adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy with high postoperative recurrence rates and poor prognosis. Mitotane remains the only approved agent for ACC, exerting antitumor effects by disrupting mitochondrial integrity, inhibiting steroidogenic enzymes, and interfering with cholesterol metabolism.

21 Jan 2026

Proimmune introduces Mastering Immunity 2026 - Shanghai symposium to address key immunogenicity challenges

ProImmune Ltd, a global leader in immunological reagents and services, announced the launch of Mastering Immunity 2026 - Shanghai, an inaugural symposium in China providing practical, real-world guidance to help drug developers manage immunogenicity risk.

21 Jan 2026

Algae may help meet future protein demand without straining the planet

This narrative review evaluates clinical evidence on algae and algal proteins as sustainable, nutrient-dense food sources with high protein quality and bioactive compounds. Findings suggest potential benefits for muscle protein synthesis, cardiometabolic markers, immune modulation, and antioxidant status, while emphasizing heterogeneity, short-term data, and the need for longer clinical trials.

20 Jan 2026

Researchers discover a biochemical route that plays role in Parkinson's disease

About 1 million Americans suffer from Parkinson's disease, with around 90,000 new cases diagnosed each year, according to the Parkinson's Foundation.

20 Jan 2026

Orchestrating a global response to the mosquito threat

Mosquitoes are more than just a summer nuisance; they pose a significant global health challenge, killing over 700,000 people every year. Mosquito-borne diseases such as dengue, Zika, and chikungunya were once considered distant threats, but climate change and rapid urbanisation are enabling mosquitoes to spread to new areas, including parts of Europe.

20 Jan 2026

High-dose flu shots lower hospitalization risk in older adults

High-dose influenza vaccines may lower serious hospitalization rates in older adults, particularly those with diabetes, according to a recent Danish trial.

20 Jan 2026

Insulin anxiety and workplace barriers complicate gestational diabetes care

Insulin use in gestational diabetes presents challenges; education and support are key to overcoming fears and ensuring effective self-management for mothers.

20 Jan 2026

Can dietary supplements support nutrition security as climate change disrupts food systems?

Environmental change is reshaping food availability, nutrient quality, and health risks, exposing major gaps in how nutrition science addresses climate-related stressors. This perspective argues that dietary supplements may have a context-dependent role but require rigorous, interdisciplinary research before informing public health action.

19 Jan 2026

Purdue-developed LENN system enhances stability and targeting of mRNA cancer therapies

Published, peer-reviewed research shows a patent-pending, virus-mimicking platform technology developed at Purdue University improves upon traditional methods of targeting bladder cancer cells with messenger RNA (mRNA) therapies.

16 Jan 2026

New review examines the growing global use of melatonin among pediatric populations

Sleep problems are increasingly common among children and adolescents, affecting emotional regulation, cognitive development, and healthy conditions.

16 Jan 2026

Study provides a new paradigm for managing transplant‑related immune complications

Acute graft-versus-host disease (aGVHD) is one of the most serious complications after allogeneic hematopoietic stem cell transplantation (allo‑HSCT).

16 Jan 2026

PRoRota-project aims to fight diarrhea in children using probiotics, hygiene, and models

The PRoRota-project will use probiotics, improved education in hygiene and advanced mathematical models to prevent children from dying of diarrhea in low and middle-income countries.

16 Jan 2026

FDA-cleared ADHD device not effective in reducing symptoms

A large multicenter clinical trial led by King's College London with 150 children and adolescents has shown that a device cleared by the US FDA to treat ADHD is not effective in reducing symptoms.

16 Jan 2026

Smoking cessation apps can boost quit rates, especially alongside medication

Smartphone apps show promise in smoking cessation, outperforming minimal support and enhancing traditional interventions, according to a recent meta-analysis.

16 Jan 2026

Vagus nerve stimulation shows lasting benefit in treatment-resistant depression

Findings reveal that vagus nerve stimulation leads to lasting benefits in treatment-resistant depression, improving function and quality of life over two years.

16 Jan 2026

Bio-engineered skin grafts offer new hope for severe burn injuries

Bio-engineered skin grafts can play an important role in the treatment of burn victims. Researchers at the University of Zurich have been working on new approaches for such grafts for over 15 years.

15 Jan 2026

Repurposed Alzheimer’s medication offers low-cost hope for sickle cell anemia

Sickle cell anemia is the world's most common genetic disorder. It causes the red blood pigment hemoglobin to crystallize, which results in rigid, malformed red blood cells with a sickle shape.

15 Jan 2026

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Efficacy News and Research

GLP-1 weight-loss drugs show early promise for treating addiction

Study finds no safety or efficacy gap between paracetamol and ibuprofen for neonatal PDA

NuSHs can be a promising therapeutic strategy for preventing MASH-related hepatocellular carcinoma

Mitotane’s role in the management of adrenocortical carcinoma

Proimmune introduces Mastering Immunity 2026 - Shanghai symposium to address key immunogenicity challenges

Algae may help meet future protein demand without straining the planet

Researchers discover a biochemical route that plays role in Parkinson's disease

Orchestrating a global response to the mosquito threat

High-dose flu shots lower hospitalization risk in older adults

Insulin anxiety and workplace barriers complicate gestational diabetes care

Can dietary supplements support nutrition security as climate change disrupts food systems?

Purdue-developed LENN system enhances stability and targeting of mRNA cancer therapies

New review examines the growing global use of melatonin among pediatric populations

Study provides a new paradigm for managing transplant‑related immune complications

PRoRota-project aims to fight diarrhea in children using probiotics, hygiene, and models

FDA-cleared ADHD device not effective in reducing symptoms

Smoking cessation apps can boost quit rates, especially alongside medication

Vagus nerve stimulation shows lasting benefit in treatment-resistant depression

Bio-engineered skin grafts offer new hope for severe burn injuries

Repurposed Alzheimer’s medication offers low-cost hope for sickle cell anemia

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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